Nox2 activation in Covid-19
Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182)...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231720308600 |
| _version_ | 1818958417792860160 |
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| author | Francesco Violi Alessandra Oliva Roberto Cangemi Giancarlo Ceccarelli Pasquale Pignatelli Roberto Carnevale Vittoria Cammisotto Miriam Lichtner Francesco Alessandri Massimiliano De Angelis Maria Claudia Miele Gabriella D'Ettorre Franco Ruberto Mario Venditti Francesco Pugliese Claudio Maria Mastroianni |
| author_facet | Francesco Violi Alessandra Oliva Roberto Cangemi Giancarlo Ceccarelli Pasquale Pignatelli Roberto Carnevale Vittoria Cammisotto Miriam Lichtner Francesco Alessandri Massimiliano De Angelis Maria Claudia Miele Gabriella D'Ettorre Franco Ruberto Mario Venditti Francesco Pugliese Claudio Maria Mastroianni |
| author_sort | Francesco Violi |
| collection | DOAJ |
| description | Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182) and controls (n = 91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n = 35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients. |
| first_indexed | 2024-12-20T11:25:25Z |
| format | Article |
| id | doaj.art-128ff2c6de1642ea974bf0416c86430e |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-20T11:25:25Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-128ff2c6de1642ea974bf0416c86430e2022-12-21T19:42:23ZengElsevierRedox Biology2213-23172020-09-0136101655Nox2 activation in Covid-19Francesco Violi0Alessandra Oliva1Roberto Cangemi2Giancarlo Ceccarelli3Pasquale Pignatelli4Roberto Carnevale5Vittoria Cammisotto6Miriam Lichtner7Francesco Alessandri8Massimiliano De Angelis9Maria Claudia Miele10Gabriella D'Ettorre11Franco Ruberto12Mario Venditti13Francesco Pugliese14Claudio Maria Mastroianni15Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy; Corresponding author. I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, Roma, 00161, Italy.Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, ItalyDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy; Mediterranea Cardiocentro, 80122 Napoli, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, ItalyDepartment of General Surgery Paride Stefanini, Sapienza University of Rome, Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, ItalyDepartment of General Surgery Paride Stefanini, Sapienza University of Rome, Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, ItalyNox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182) and controls (n = 91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n = 35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.http://www.sciencedirect.com/science/article/pii/S2213231720308600Covid-19Nox-2NADPH oxidaseThrombosis |
| spellingShingle | Francesco Violi Alessandra Oliva Roberto Cangemi Giancarlo Ceccarelli Pasquale Pignatelli Roberto Carnevale Vittoria Cammisotto Miriam Lichtner Francesco Alessandri Massimiliano De Angelis Maria Claudia Miele Gabriella D'Ettorre Franco Ruberto Mario Venditti Francesco Pugliese Claudio Maria Mastroianni Nox2 activation in Covid-19 Redox Biology Covid-19 Nox-2 NADPH oxidase Thrombosis |
| title | Nox2 activation in Covid-19 |
| title_full | Nox2 activation in Covid-19 |
| title_fullStr | Nox2 activation in Covid-19 |
| title_full_unstemmed | Nox2 activation in Covid-19 |
| title_short | Nox2 activation in Covid-19 |
| title_sort | nox2 activation in covid 19 |
| topic | Covid-19 Nox-2 NADPH oxidase Thrombosis |
| url | http://www.sciencedirect.com/science/article/pii/S2213231720308600 |
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