Manipulation of Epithelial Differentiation by HPV Oncoproteins
Papillomaviruses replicate and cause disease in stratified squamous epithelia. Epithelial differentiation is essential for the progression of papillomavirus replication, but differentiation is also impaired by papillomavirus-encoded proteins. The papillomavirus E6 and E7 oncoproteins partially inhib...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/11/4/369 |
| _version_ | 1811269301511913472 |
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| author | Elizabeth A. White |
| author_facet | Elizabeth A. White |
| author_sort | Elizabeth A. White |
| collection | DOAJ |
| description | Papillomaviruses replicate and cause disease in stratified squamous epithelia. Epithelial differentiation is essential for the progression of papillomavirus replication, but differentiation is also impaired by papillomavirus-encoded proteins. The papillomavirus E6 and E7 oncoproteins partially inhibit and/or delay epithelial differentiation and some of the mechanisms by which they do so are beginning to be defined. This review will outline the key features of the relationship between HPV infection and differentiation and will summarize the data indicating that papillomaviruses alter epithelial differentiation. It will describe what is known so far and will highlight open questions about the differentiation-inhibitory mechanisms employed by the papillomaviruses. |
| first_indexed | 2024-04-12T21:38:36Z |
| format | Article |
| id | doaj.art-128ff933d6b442069537a7bf645f33b4 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-12T21:38:36Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-128ff933d6b442069537a7bf645f33b42022-12-22T03:15:49ZengMDPI AGViruses1999-49152019-04-0111436910.3390/v11040369v11040369Manipulation of Epithelial Differentiation by HPV OncoproteinsElizabeth A. White0Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USAPapillomaviruses replicate and cause disease in stratified squamous epithelia. Epithelial differentiation is essential for the progression of papillomavirus replication, but differentiation is also impaired by papillomavirus-encoded proteins. The papillomavirus E6 and E7 oncoproteins partially inhibit and/or delay epithelial differentiation and some of the mechanisms by which they do so are beginning to be defined. This review will outline the key features of the relationship between HPV infection and differentiation and will summarize the data indicating that papillomaviruses alter epithelial differentiation. It will describe what is known so far and will highlight open questions about the differentiation-inhibitory mechanisms employed by the papillomaviruses.https://www.mdpi.com/1999-4915/11/4/369virustransformationepithelialdifferentiationHPV |
| spellingShingle | Elizabeth A. White Manipulation of Epithelial Differentiation by HPV Oncoproteins Viruses virus transformation epithelial differentiation HPV |
| title | Manipulation of Epithelial Differentiation by HPV Oncoproteins |
| title_full | Manipulation of Epithelial Differentiation by HPV Oncoproteins |
| title_fullStr | Manipulation of Epithelial Differentiation by HPV Oncoproteins |
| title_full_unstemmed | Manipulation of Epithelial Differentiation by HPV Oncoproteins |
| title_short | Manipulation of Epithelial Differentiation by HPV Oncoproteins |
| title_sort | manipulation of epithelial differentiation by hpv oncoproteins |
| topic | virus transformation epithelial differentiation HPV |
| url | https://www.mdpi.com/1999-4915/11/4/369 |
| work_keys_str_mv | AT elizabethawhite manipulationofepithelialdifferentiationbyhpvoncoproteins |