Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral <i>Paralemnalia thyrsoide</i>
The organic extracts of the Red Sea soft coral <i>Paralemnalia thyrsoides</i> has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (<b>1</b>, <b>2</b>). In addition to these newly characterized compounds, ten known metabolit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/10/1158 |
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| author | Abdelsamed I. Elshamy Tarik A. Mohamed Eman M. Elkady Ibrahim A. Saleh Ahmed A. El-Beih Montaser A. Alhammady Shinji Ohta Akemi Umeyama Paul W. Paré Mohamed-Elamir F. Hegazy |
| author_facet | Abdelsamed I. Elshamy Tarik A. Mohamed Eman M. Elkady Ibrahim A. Saleh Ahmed A. El-Beih Montaser A. Alhammady Shinji Ohta Akemi Umeyama Paul W. Paré Mohamed-Elamir F. Hegazy |
| author_sort | Abdelsamed I. Elshamy |
| collection | DOAJ |
| description | The organic extracts of the Red Sea soft coral <i>Paralemnalia thyrsoides</i> has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (<b>1</b>, <b>2</b>). In addition to these newly characterized compounds, ten known metabolites (<b>3</b>–<b>12</b>) were isolated. Previously reported compounds were elucidated by literature comparison of spectroscopic data (1D and 2D NMR as well as MS data). In vitro antimicrobial activity was investigated for compounds (<b>1</b>–<b>12</b>) against <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Candida albicans</i> and <i>Aspergillus niger</i>. Compound <b>5</b> showed antimicrobial activity against all assayed microorganisms. |
| first_indexed | 2024-03-10T06:45:57Z |
| format | Article |
| id | doaj.art-129154111b57432a8ae9f62d73079eeb |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T06:45:57Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-129154111b57432a8ae9f62d73079eeb2023-11-22T17:12:58ZengMDPI AGAntibiotics2079-63822021-09-011010115810.3390/antibiotics10101158Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral <i>Paralemnalia thyrsoide</i>Abdelsamed I. Elshamy0Tarik A. Mohamed1Eman M. Elkady2Ibrahim A. Saleh3Ahmed A. El-Beih4Montaser A. Alhammady5Shinji Ohta6Akemi Umeyama7Paul W. Paré8Mohamed-Elamir F. Hegazy9Department of Natural Compounds Chemistry, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, EgyptChemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, EgyptNational Institute of Oceanography & Fisheries, NIOF, Cairo 11516, EgyptChemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, EgyptChemistry of Natural& Microbial Products Department, National Research Centre, Dokki, Giza 12622, EgyptNational Institute of Oceanography & Fisheries, NIOF, Cairo 11516, EgyptGraduate School of Integrated Sciences for Life, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-8521, JapanFaculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, JapanDepartment of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79409, USAChemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, EgyptThe organic extracts of the Red Sea soft coral <i>Paralemnalia thyrsoides</i> has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (<b>1</b>, <b>2</b>). In addition to these newly characterized compounds, ten known metabolites (<b>3</b>–<b>12</b>) were isolated. Previously reported compounds were elucidated by literature comparison of spectroscopic data (1D and 2D NMR as well as MS data). In vitro antimicrobial activity was investigated for compounds (<b>1</b>–<b>12</b>) against <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Candida albicans</i> and <i>Aspergillus niger</i>. Compound <b>5</b> showed antimicrobial activity against all assayed microorganisms.https://www.mdpi.com/2079-6382/10/10/1158<i>Paralemnalia thyrsoide</i>sesquiterpenesparalemnolinsantimicrobial |
| spellingShingle | Abdelsamed I. Elshamy Tarik A. Mohamed Eman M. Elkady Ibrahim A. Saleh Ahmed A. El-Beih Montaser A. Alhammady Shinji Ohta Akemi Umeyama Paul W. Paré Mohamed-Elamir F. Hegazy Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral <i>Paralemnalia thyrsoide</i> Antibiotics <i>Paralemnalia thyrsoide</i> sesquiterpenes paralemnolins antimicrobial |
| title | Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral <i>Paralemnalia thyrsoide</i> |
| title_full | Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral <i>Paralemnalia thyrsoide</i> |
| title_fullStr | Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral <i>Paralemnalia thyrsoide</i> |
| title_full_unstemmed | Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral <i>Paralemnalia thyrsoide</i> |
| title_short | Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral <i>Paralemnalia thyrsoide</i> |
| title_sort | paralemnolins x and y new antimicrobial sesquiterpenoids from the soft coral i paralemnalia thyrsoide i |
| topic | <i>Paralemnalia thyrsoide</i> sesquiterpenes paralemnolins antimicrobial |
| url | https://www.mdpi.com/2079-6382/10/10/1158 |
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