Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment
Abstract Chronic lung diseases include an array of conditions that impact airways and lung structures, leading to considerable societal burdens. Mesenchymal stem cells (MSCs) and their exosomes (MSC-exos) can be used for cell therapy and exhibit a diverse spectrum of anti-inflammatory, antifibrotic,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-023-04729-9 |
| _version_ | 1827590325066006528 |
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| author | Zhengyao Zhai Tairong Cui Jialiang Chen Xulong Mao Ting Zhang |
| author_facet | Zhengyao Zhai Tairong Cui Jialiang Chen Xulong Mao Ting Zhang |
| author_sort | Zhengyao Zhai |
| collection | DOAJ |
| description | Abstract Chronic lung diseases include an array of conditions that impact airways and lung structures, leading to considerable societal burdens. Mesenchymal stem cells (MSCs) and their exosomes (MSC-exos) can be used for cell therapy and exhibit a diverse spectrum of anti-inflammatory, antifibrotic, and immunomodulatory properties. Engineered MSC-exos possesses enhanced capabilities for targeted drug delivery, resulting in more potent targeting effects. Through various engineering modifications, these exosomes can exert many biological effects, resulting in specific therapeutic outcomes for many diseases. Moreover, engineered stem cell exosomes may exhibit an increased capacity to traverse physiological barriers and infiltrate protected lesions, thereby exerting their therapeutic effects. These characteristics render them a promising therapeutic agent for chronic pulmonary diseases. This article discusses and reviews the strategies and mechanisms of engineered MSC-exos in the treatment of chronic respiratory diseases based on many studies to provide new solutions for these diseases. |
| first_indexed | 2024-03-09T01:15:18Z |
| format | Article |
| id | doaj.art-129245cef314483bbc5d0170b6828ffa |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-09T01:15:18Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-129245cef314483bbc5d0170b6828ffa2023-12-10T12:29:47ZengBMCJournal of Translational Medicine1479-58762023-12-0121111110.1186/s12967-023-04729-9Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatmentZhengyao Zhai0Tairong Cui1Jialiang Chen2Xulong Mao3Ting Zhang4The First School of Medicine, School of Information and Engineering, The First Affiliated Hospital of Wenzhou Medical UniversityThe First School of Medicine, School of Information and Engineering, The First Affiliated Hospital of Wenzhou Medical UniversityThe First School of Medicine, School of Information and Engineering, The First Affiliated Hospital of Wenzhou Medical UniversityKey Laboratory of Heart and Lung, Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Rheumatology, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Chronic lung diseases include an array of conditions that impact airways and lung structures, leading to considerable societal burdens. Mesenchymal stem cells (MSCs) and their exosomes (MSC-exos) can be used for cell therapy and exhibit a diverse spectrum of anti-inflammatory, antifibrotic, and immunomodulatory properties. Engineered MSC-exos possesses enhanced capabilities for targeted drug delivery, resulting in more potent targeting effects. Through various engineering modifications, these exosomes can exert many biological effects, resulting in specific therapeutic outcomes for many diseases. Moreover, engineered stem cell exosomes may exhibit an increased capacity to traverse physiological barriers and infiltrate protected lesions, thereby exerting their therapeutic effects. These characteristics render them a promising therapeutic agent for chronic pulmonary diseases. This article discusses and reviews the strategies and mechanisms of engineered MSC-exos in the treatment of chronic respiratory diseases based on many studies to provide new solutions for these diseases.https://doi.org/10.1186/s12967-023-04729-9Mesenchymal stem cellEngineered exosomeChronic lung diseaseTherapeutic potential |
| spellingShingle | Zhengyao Zhai Tairong Cui Jialiang Chen Xulong Mao Ting Zhang Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment Journal of Translational Medicine Mesenchymal stem cell Engineered exosome Chronic lung disease Therapeutic potential |
| title | Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment |
| title_full | Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment |
| title_fullStr | Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment |
| title_full_unstemmed | Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment |
| title_short | Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment |
| title_sort | advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment |
| topic | Mesenchymal stem cell Engineered exosome Chronic lung disease Therapeutic potential |
| url | https://doi.org/10.1186/s12967-023-04729-9 |
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