Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer

Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer

The K-ras gene is frequently mutated in colorectal cancer and has been associated with tumor initiation and progression; approximately 90% of the activating mutations are found in codons 12 and 13 of exon 1 and just under 5% in codon 61 located in exon 2. These mutations determine single aminoacidic...

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Bibliographic Details
Main Authors: Fiorella Guadagni, Cristiano Ialongo, Giuseppe Maria Ettorre, Renato Covello, Maria Laura De Marchis, Giorgia Ludovici, Annalisa Savonarola, Raffaele Palmirotta
Format: Article
Language:English
Published: Via Medica 2012-01-01
Series:Folia Histochemica et Cytobiologica
Subjects:
colorectal cancer
K-ras
double mutation
Online Access:http://czasopisma.viamedica.pl/fhc/article/view/14737

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