The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic Review
Vitamin D has an immune-modulating effect on respiratory tract infections. For this reason, it has been proposed as part of the treatment in COVID-19. Furthermore, vitamin D deficiency has been associated with worse clinical outcomes of this disease. The aim of this systematic review was to determin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/20/12424 |
| _version_ | 1797472738166702080 |
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| author | Ángela Feiner Solís Ana Avedillo Salas María José Luesma Bartolomé Sonia Santander Ballestín |
| author_facet | Ángela Feiner Solís Ana Avedillo Salas María José Luesma Bartolomé Sonia Santander Ballestín |
| author_sort | Ángela Feiner Solís |
| collection | DOAJ |
| description | Vitamin D has an immune-modulating effect on respiratory tract infections. For this reason, it has been proposed as part of the treatment in COVID-19. Furthermore, vitamin D deficiency has been associated with worse clinical outcomes of this disease. The aim of this systematic review was to determine whether vitamin D supplementation modifies the disease course. Therefore, eleven studies involving randomised clinical trials are analysed, in which groups of COVID-19 patients with or without vitamin D supplementation as part of the treatment are compared. A control group was treated with best available therapy, and in some of the clinical trials, also with a placebo. According to the outcomes, it seems that patients benefit from receiving a daily or maintained in time vitamin D dose regardless of vitamin D serum levels at the beginning of the trial. The administration of a single vitamin D dose does not seem to have any effect on the health status of these patients. However, the outcomes are heterogeneous and larger clinical trials are necessary. |
| first_indexed | 2024-03-09T20:05:29Z |
| format | Article |
| id | doaj.art-129421cbf79e41ba83f6a0c7f37ca4c4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:05:29Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-129421cbf79e41ba83f6a0c7f37ca4c42023-11-24T00:31:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123201242410.3390/ijms232012424The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic ReviewÁngela Feiner Solís0Ana Avedillo Salas1María José Luesma Bartolomé2Sonia Santander Ballestín3Department of Pharmacology, Physiology and Legal and Forensic Medicine, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, SpainDepartment of Pharmacology, Physiology and Legal and Forensic Medicine, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, SpainDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, SpainDepartment of Pharmacology, Physiology and Legal and Forensic Medicine, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, SpainVitamin D has an immune-modulating effect on respiratory tract infections. For this reason, it has been proposed as part of the treatment in COVID-19. Furthermore, vitamin D deficiency has been associated with worse clinical outcomes of this disease. The aim of this systematic review was to determine whether vitamin D supplementation modifies the disease course. Therefore, eleven studies involving randomised clinical trials are analysed, in which groups of COVID-19 patients with or without vitamin D supplementation as part of the treatment are compared. A control group was treated with best available therapy, and in some of the clinical trials, also with a placebo. According to the outcomes, it seems that patients benefit from receiving a daily or maintained in time vitamin D dose regardless of vitamin D serum levels at the beginning of the trial. The administration of a single vitamin D dose does not seem to have any effect on the health status of these patients. However, the outcomes are heterogeneous and larger clinical trials are necessary.https://www.mdpi.com/1422-0067/23/20/12424vitamin DSARS-CoV-2vitamin D deficiencysupplementationimmune system |
| spellingShingle | Ángela Feiner Solís Ana Avedillo Salas María José Luesma Bartolomé Sonia Santander Ballestín The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic Review International Journal of Molecular Sciences vitamin D SARS-CoV-2 vitamin D deficiency supplementation immune system |
| title | The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic Review |
| title_full | The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic Review |
| title_fullStr | The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic Review |
| title_full_unstemmed | The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic Review |
| title_short | The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic Review |
| title_sort | effects of vitamin d supplementation in covid 19 patients a systematic review |
| topic | vitamin D SARS-CoV-2 vitamin D deficiency supplementation immune system |
| url | https://www.mdpi.com/1422-0067/23/20/12424 |
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