High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test
Obesity is characterized by massive adipose tissue accumulation and is associated with psychiatric disorders and cognitive impairment in human and animal models. However, it is unclear whether high-fat diet (HFD)-induced obesity presents a risk of psychiatric disorders and cognitive impairment. To e...
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MDPI AG
2020-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/7/2036 |
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| author | Kaichi Yoshizaki Masato Asai Taichi Hara |
| author_facet | Kaichi Yoshizaki Masato Asai Taichi Hara |
| author_sort | Kaichi Yoshizaki |
| collection | DOAJ |
| description | Obesity is characterized by massive adipose tissue accumulation and is associated with psychiatric disorders and cognitive impairment in human and animal models. However, it is unclear whether high-fat diet (HFD)-induced obesity presents a risk of psychiatric disorders and cognitive impairment. To examine this question, we conducted systematic behavioral analyses in C57BL/6J mice (male, 8-week-old) fed an HFD for 7 weeks. C57BL/6J mice fed an HFD showed significantly increased body weight, hyperlocomotion in the open-field test (OFT) and Y-maze test (YMZT), and impaired sucrose preference in the sucrose consumption test, compared to mice fed a normal diet. Neither body weight nor body weight gain was associated with any of the behavioral traits we examined. Working memory, as assessed by the YMZT, and anxiety-like behavior, as assessed by the elevated plus maze test (EPMT), were significantly correlated with mice fed an HFD, although these behavioral traits did not affect the entire group. These results suggest that HFD-induced obesity does not induce neuropsychiatric symptoms in C57BL/6J mice. Rather, HFD improved working memory in C57BL/6J mice with less anxiety, indicating that an HFD might be beneficial under limited conditions. Correlation analysis of individual traits is a useful tool to determine those conditions. |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:35:14Z |
| publishDate | 2020-07-01 |
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| spelling | doaj.art-12943e6bb61b44d69eebff8b9f5fe97d2023-11-20T06:16:23ZengMDPI AGNutrients2072-66432020-07-01127203610.3390/nu12072036High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze TestKaichi Yoshizaki0Masato Asai1Taichi Hara2Department of Disease Model, Institute for Developmental Research, Aichi Developmental Disability Center, Aichi 480-0392, JapanDepartment of Disease Model, Institute for Developmental Research, Aichi Developmental Disability Center, Aichi 480-0392, JapanLaboratory of Food and Life Science, Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, JapanObesity is characterized by massive adipose tissue accumulation and is associated with psychiatric disorders and cognitive impairment in human and animal models. However, it is unclear whether high-fat diet (HFD)-induced obesity presents a risk of psychiatric disorders and cognitive impairment. To examine this question, we conducted systematic behavioral analyses in C57BL/6J mice (male, 8-week-old) fed an HFD for 7 weeks. C57BL/6J mice fed an HFD showed significantly increased body weight, hyperlocomotion in the open-field test (OFT) and Y-maze test (YMZT), and impaired sucrose preference in the sucrose consumption test, compared to mice fed a normal diet. Neither body weight nor body weight gain was associated with any of the behavioral traits we examined. Working memory, as assessed by the YMZT, and anxiety-like behavior, as assessed by the elevated plus maze test (EPMT), were significantly correlated with mice fed an HFD, although these behavioral traits did not affect the entire group. These results suggest that HFD-induced obesity does not induce neuropsychiatric symptoms in C57BL/6J mice. Rather, HFD improved working memory in C57BL/6J mice with less anxiety, indicating that an HFD might be beneficial under limited conditions. Correlation analysis of individual traits is a useful tool to determine those conditions.https://www.mdpi.com/2072-6643/12/7/2036high-fat dietpsychiatric behaviorcognitive behaviorC57BL/6Jobesity |
| spellingShingle | Kaichi Yoshizaki Masato Asai Taichi Hara High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test Nutrients high-fat diet psychiatric behavior cognitive behavior C57BL/6J obesity |
| title | High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test |
| title_full | High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test |
| title_fullStr | High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test |
| title_full_unstemmed | High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test |
| title_short | High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test |
| title_sort | high fat diet enhances working memory in the y maze test in male c57bl 6j mice with less anxiety in the elevated plus maze test |
| topic | high-fat diet psychiatric behavior cognitive behavior C57BL/6J obesity |
| url | https://www.mdpi.com/2072-6643/12/7/2036 |
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