Polysaccharide-Zein Composite Nanoparticles for Enhancing Cellular Uptake and Oral Bioavailability of Curcumin: Characterization, Anti-colorectal Cancer Effect, and Pharmacokinetics

Polysaccharide-Zein Composite Nanoparticles for Enhancing Cellular Uptake and Oral Bioavailability of Curcumin: Characterization, Anti-colorectal Cancer Effect, and Pharmacokinetics

Curcumin (CUR) has demonstrated promising potential as a therapeutic agent against colorectal cancer (CRC). However, its intrinsic shortcomings, including oxidative instability, sensitivity to gastrointestinal (GI) hydrolytic/enzymatic action, and susceptibility to biotransformation and systemic eli...

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Bibliographic Details
Main Authors: Lu Liu, Shufang Yang, Feng Chen, Ka-Wing Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Nutrition
Subjects:
curcumin
polysaccharide-zein composite nanoparticles
cellular uptake
colorectal cancer
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.846282/full

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