Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
Abstract We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-02753-6 |
| _version_ | 1818844047031140352 |
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| author | Brian W. LeBlanc Brent Cross Kelsey A. Smith Catherine Roach Jimmy Xia Yu-Chieh Chao Joshua Levitt Suguru Koyama Christopher I. Moore Carl Y. Saab |
| author_facet | Brian W. LeBlanc Brent Cross Kelsey A. Smith Catherine Roach Jimmy Xia Yu-Chieh Chao Joshua Levitt Suguru Koyama Christopher I. Moore Carl Y. Saab |
| author_sort | Brian W. LeBlanc |
| collection | DOAJ |
| description | Abstract We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience. |
| first_indexed | 2024-12-19T05:07:33Z |
| format | Article |
| id | doaj.art-1294ec178cf74cba946d2b0729643c9a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T05:07:33Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1294ec178cf74cba946d2b0729643c9a2022-12-21T20:34:52ZengNature PortfolioScientific Reports2045-23222017-05-01711810.1038/s41598-017-02753-6Thalamic Bursts Down-regulate Cortical Theta and Nociceptive BehaviorBrian W. LeBlanc0Brent Cross1Kelsey A. Smith2Catherine Roach3Jimmy Xia4Yu-Chieh Chao5Joshua Levitt6Suguru Koyama7Christopher I. Moore8Carl Y. Saab9Department of Neurosurgery, Rhode Island HospitalDepartment of Neurosurgery, Rhode Island HospitalDepartment of Neurosurgery, Rhode Island HospitalDepartment of Neurosurgery, Rhode Island HospitalDepartment of Neurosurgery, Rhode Island HospitalDepartment of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical UniversityCenter for Biomedical Engineering, Brown UniversityDepartment of Neurosurgery, Rhode Island HospitalDepartment of Neuroscience, Brown UniversityDepartment of Neurosurgery, Rhode Island HospitalAbstract We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience.https://doi.org/10.1038/s41598-017-02753-6 |
| spellingShingle | Brian W. LeBlanc Brent Cross Kelsey A. Smith Catherine Roach Jimmy Xia Yu-Chieh Chao Joshua Levitt Suguru Koyama Christopher I. Moore Carl Y. Saab Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior Scientific Reports |
| title | Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior |
| title_full | Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior |
| title_fullStr | Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior |
| title_full_unstemmed | Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior |
| title_short | Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior |
| title_sort | thalamic bursts down regulate cortical theta and nociceptive behavior |
| url | https://doi.org/10.1038/s41598-017-02753-6 |
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