Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT
Background: Despite major advances in assisted reproductive techniques, the implantation rates remain relatively low. Some studies have demonstrated that intrauterine infusion of granulocyte colony stimulating factor (G-CSF) improves implantation in infertile women. Objective: To assess the G-CSF e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Science, Yazd, Iran
2016-05-01
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| Series: | Iranian Journal of Reproductive Medicine |
| Online Access: | http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1934/982 |
| _version_ | 1818380449844559872 |
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| author | Maryam Eftekhar Robabe Hosseinisadat Ramesh Baradaran Elham Naghshineh |
| author_facet | Maryam Eftekhar Robabe Hosseinisadat Ramesh Baradaran Elham Naghshineh |
| author_sort | Maryam Eftekhar |
| collection | DOAJ |
| description | Background: Despite major advances in assisted reproductive techniques, the implantation rates remain relatively low. Some studies have demonstrated that intrauterine infusion of granulocyte colony stimulating factor (G-CSF) improves implantation in infertile women.
Objective: To assess the G-CSF effects on IVF outcomes in women with normal
endometrial thickness.
Materials and methods: In this randomized controlled clinical trial, 100 infertile women with normal endometrial thickness who were candidate for IVF were evaluated in two groups. Exclusion criteria were positive history of repeated implantation failure (RIF), endocrine disorders, severe endometriosis, congenital or acquired uterine anomaly and contraindication for G-CSF (renal disease, sickle cell disease, or malignancy). In G-CSF group (n=50), 300 μg trans cervical intrauterine of G-CSF was administered at the oocyte retrieval day. Controls (n=50) were treated with standard protocol. Chemical, clinical and ongoing pregnancy rates, implantation rate, and miscarriage rate were compared between groups.
Results: Number of total and mature oocytes (MII), two pronuclei (2PN), total embryos, transferred embryos, quality of transferred embryos, and fertilization rate did not differ significantly between two groups. So there were no significant differences between groups in chemical, clinical and ongoing pregnancy rate, implantation rate, and miscarriage rate
Conclusion: our result showed in normal IVF patients with normal endometrial thickness, the intrauterine infusion of G-CSF did not improve pregnancy outcomes. |
| first_indexed | 2024-12-14T02:18:52Z |
| format | Article |
| id | doaj.art-1296e3db3f804a288710349ec37f2c6b |
| institution | Directory Open Access Journal |
| issn | 1680-6433 2008-2177 |
| language | English |
| last_indexed | 2024-12-14T02:18:52Z |
| publishDate | 2016-05-01 |
| publisher | Shahid Sadoughi University of Medical Science, Yazd, Iran |
| record_format | Article |
| series | Iranian Journal of Reproductive Medicine |
| spelling | doaj.art-1296e3db3f804a288710349ec37f2c6b2022-12-21T23:20:33ZengShahid Sadoughi University of Medical Science, Yazd, IranIranian Journal of Reproductive Medicine1680-64332008-21772016-05-01145341346Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCTMaryam Eftekhar0Robabe Hosseinisadat1Ramesh Baradaran2Elham Naghshineh3Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, IranResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, IranResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Despite major advances in assisted reproductive techniques, the implantation rates remain relatively low. Some studies have demonstrated that intrauterine infusion of granulocyte colony stimulating factor (G-CSF) improves implantation in infertile women. Objective: To assess the G-CSF effects on IVF outcomes in women with normal endometrial thickness. Materials and methods: In this randomized controlled clinical trial, 100 infertile women with normal endometrial thickness who were candidate for IVF were evaluated in two groups. Exclusion criteria were positive history of repeated implantation failure (RIF), endocrine disorders, severe endometriosis, congenital or acquired uterine anomaly and contraindication for G-CSF (renal disease, sickle cell disease, or malignancy). In G-CSF group (n=50), 300 μg trans cervical intrauterine of G-CSF was administered at the oocyte retrieval day. Controls (n=50) were treated with standard protocol. Chemical, clinical and ongoing pregnancy rates, implantation rate, and miscarriage rate were compared between groups. Results: Number of total and mature oocytes (MII), two pronuclei (2PN), total embryos, transferred embryos, quality of transferred embryos, and fertilization rate did not differ significantly between two groups. So there were no significant differences between groups in chemical, clinical and ongoing pregnancy rate, implantation rate, and miscarriage rate Conclusion: our result showed in normal IVF patients with normal endometrial thickness, the intrauterine infusion of G-CSF did not improve pregnancy outcomes.http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1934/982 |
| spellingShingle | Maryam Eftekhar Robabe Hosseinisadat Ramesh Baradaran Elham Naghshineh Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT Iranian Journal of Reproductive Medicine |
| title | Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT |
| title_full | Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT |
| title_fullStr | Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT |
| title_full_unstemmed | Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT |
| title_short | Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT |
| title_sort | effect of granulocyte colony stimulating factor g csf on ivf outcomes in infertile women an rct |
| url | http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1934/982 |
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