Weight Loss Following Bariatric Surgery in People with or without Metabolic Syndrome: A 5-Year Observational Comparative Study
Aim: Whilst bariatric surgery is the most effective treatment for severe obesity, the aim of this study was to evaluate whether postoperative weight loss is similar in patients with or without metabolic syndrome. Methods: We performed a 5-year observational retrospective comparative cohort analysis...
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/1/256 |
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| author | Sharanniyan Ragavan Omar Elhelw Waseem Majeed Bilal Alkhaffaf Siba Senapati Basil J. Ammori Rajshekhar N. Mudaliar Akheel A. Syed |
| author_facet | Sharanniyan Ragavan Omar Elhelw Waseem Majeed Bilal Alkhaffaf Siba Senapati Basil J. Ammori Rajshekhar N. Mudaliar Akheel A. Syed |
| author_sort | Sharanniyan Ragavan |
| collection | DOAJ |
| description | Aim: Whilst bariatric surgery is the most effective treatment for severe obesity, the aim of this study was to evaluate whether postoperative weight loss is similar in patients with or without metabolic syndrome. Methods: We performed a 5-year observational retrospective comparative cohort analysis of bariatric surgery in 333 patients (72% women) without (<i>Group A</i>, n = 133) or with (<i>Group B</i>, n = 200) metabolic syndrome at baseline. Results: Overall mean (SD) baseline body mass index was 51.7 (7.5) with no significant difference between groups. Overall mean percent total weight loss (%TWL) was 31.9% by 24 months after surgery. Although %TWL was greater in <i>Group A</i> (34.9%) than in <i>Group B</i> (30.2%, <i>p</i> = 0.006) at 24 months, there were no significant differences between groups subsequently up to 60 months of follow-up. Systolic and diastolic blood pressures and lipid profiles improved in both groups. In patients with metabolic syndrome at baseline, mean HbA1c reduced by 36.4% at 12 months and was sustained over the study period. Conclusions: We report that bariatric surgery results in comparable long-term weight loss in patients with or without metabolic syndrome alongside expected improvements in metabolic comorbidities. |
| first_indexed | 2024-03-08T15:03:02Z |
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| id | doaj.art-1297e065b9b94e54aba8d5e836594f0b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T15:03:02Z |
| publishDate | 2024-01-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1297e065b9b94e54aba8d5e836594f0b2024-01-10T15:01:49ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113125610.3390/jcm13010256Weight Loss Following Bariatric Surgery in People with or without Metabolic Syndrome: A 5-Year Observational Comparative StudySharanniyan Ragavan0Omar Elhelw1Waseem Majeed2Bilal Alkhaffaf3Siba Senapati4Basil J. Ammori5Rajshekhar N. Mudaliar6Akheel A. Syed7School of Medical Sciences, The University of Manchester, Manchester M13 9PL, UKSchool of Medical Sciences, The University of Manchester, Manchester M13 9PL, UKDepartment of Diabetes, Endocrinology and Obesity Medicine, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UKFaculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UKDepartment of Oesophago-Gastric and Bariatric Surgery, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UKFaculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UKDepartment of Diabetes, Endocrinology and Obesity Medicine, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UKDepartment of Diabetes, Endocrinology and Obesity Medicine, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UKAim: Whilst bariatric surgery is the most effective treatment for severe obesity, the aim of this study was to evaluate whether postoperative weight loss is similar in patients with or without metabolic syndrome. Methods: We performed a 5-year observational retrospective comparative cohort analysis of bariatric surgery in 333 patients (72% women) without (<i>Group A</i>, n = 133) or with (<i>Group B</i>, n = 200) metabolic syndrome at baseline. Results: Overall mean (SD) baseline body mass index was 51.7 (7.5) with no significant difference between groups. Overall mean percent total weight loss (%TWL) was 31.9% by 24 months after surgery. Although %TWL was greater in <i>Group A</i> (34.9%) than in <i>Group B</i> (30.2%, <i>p</i> = 0.006) at 24 months, there were no significant differences between groups subsequently up to 60 months of follow-up. Systolic and diastolic blood pressures and lipid profiles improved in both groups. In patients with metabolic syndrome at baseline, mean HbA1c reduced by 36.4% at 12 months and was sustained over the study period. Conclusions: We report that bariatric surgery results in comparable long-term weight loss in patients with or without metabolic syndrome alongside expected improvements in metabolic comorbidities.https://www.mdpi.com/2077-0383/13/1/256metabolic syndromeinsulin resistancegastric bypassgastrectomyweight loss |
| spellingShingle | Sharanniyan Ragavan Omar Elhelw Waseem Majeed Bilal Alkhaffaf Siba Senapati Basil J. Ammori Rajshekhar N. Mudaliar Akheel A. Syed Weight Loss Following Bariatric Surgery in People with or without Metabolic Syndrome: A 5-Year Observational Comparative Study Journal of Clinical Medicine metabolic syndrome insulin resistance gastric bypass gastrectomy weight loss |
| title | Weight Loss Following Bariatric Surgery in People with or without Metabolic Syndrome: A 5-Year Observational Comparative Study |
| title_full | Weight Loss Following Bariatric Surgery in People with or without Metabolic Syndrome: A 5-Year Observational Comparative Study |
| title_fullStr | Weight Loss Following Bariatric Surgery in People with or without Metabolic Syndrome: A 5-Year Observational Comparative Study |
| title_full_unstemmed | Weight Loss Following Bariatric Surgery in People with or without Metabolic Syndrome: A 5-Year Observational Comparative Study |
| title_short | Weight Loss Following Bariatric Surgery in People with or without Metabolic Syndrome: A 5-Year Observational Comparative Study |
| title_sort | weight loss following bariatric surgery in people with or without metabolic syndrome a 5 year observational comparative study |
| topic | metabolic syndrome insulin resistance gastric bypass gastrectomy weight loss |
| url | https://www.mdpi.com/2077-0383/13/1/256 |
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