Phenotypic characterization of miR-92a-/- mice reveals an important function of miR-92a in skeletal development.

Phenotypic characterization of miR-92a-/- mice reveals an important function of miR-92a in skeletal development.

MicroRNAs (miRNAs, miRs) emerged as key regulators of gene expression. Germline hemizygous deletion of the gene that encodes the miR-17∼92 miRNA cluster was associated with microcephaly, short stature and digital abnormalities in humans. Mice deficient for the miR-17∼92 cluster phenocopy several fea...

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Bibliographic Details
Main Authors: Daniela Penzkofer, Angelika Bonauer, Ariane Fischer, Alexander Tups, Ralf P Brandes, Andreas M Zeiher, Stefanie Dimmeler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4076267?pdf=render

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