Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats
This study evaluated the hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats. The extract of P. pinnata root-bark was prepared using a cold maceration method with 80% meth...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-09-01
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| Series: | Current Issues in Pharmacy and Medical Sciences |
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| Online Access: | https://doi.org/10.2478/cipms-2019-0023 |
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| author | Onoja Samuel O. Daniel-Igwe Gloria Ejiofor Emmanuel Mbakwe Christiana C. Okeke Ugochuhwu S. Ezeja Maxwell I. Omeh Yusuf N. Asuzu Isaac U. |
| author_facet | Onoja Samuel O. Daniel-Igwe Gloria Ejiofor Emmanuel Mbakwe Christiana C. Okeke Ugochuhwu S. Ezeja Maxwell I. Omeh Yusuf N. Asuzu Isaac U. |
| author_sort | Onoja Samuel O. |
| collection | DOAJ |
| description | This study evaluated the hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats. The extract of P. pinnata root-bark was prepared using a cold maceration method with 80% methanol and concentrated at 40°C in hot air oven. The extract was administered once daily per os at 50, 100 and 200 mg/kg for 21 consecutive days. Distilled water (5 mL/kg) and glibenclamide (2 mg/kg) were used as the vehicle and reference standard, respectively. The serum lipid profile, markers of liver and kidney functions, antioxidant status (malondialdehyde level, superoxide dismutase and catalase activities), histopathological changes in liver and kidney were examined 24h after the last treatment on day 21. The extract reduced serum lipid profile, markers of liver and kidney functions of treated rats relative to vehicle-treated rats. The superoxide dismutase and catalase activities of the extract treated rats were also elevated relative to the vehicle-treated rats. The extract reversed liver and kidney injuries induced by alloxan in the treated rats. This study provides some basic information which suggest that P. pinnata could be effective in managing diabetic complications. |
| first_indexed | 2024-12-24T03:33:06Z |
| format | Article |
| id | doaj.art-129af8119ab34e429c015742c60383b4 |
| institution | Directory Open Access Journal |
| issn | 2084-980X 2300-6676 |
| language | English |
| last_indexed | 2024-12-24T03:33:06Z |
| publishDate | 2019-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Current Issues in Pharmacy and Medical Sciences |
| spelling | doaj.art-129af8119ab34e429c015742c60383b42022-12-21T17:17:08ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2084-980X2300-66762019-09-0132312512910.2478/cipms-2019-0023cipms-2019-0023Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic ratsOnoja Samuel O.0Daniel-Igwe Gloria1Ejiofor Emmanuel2Mbakwe Christiana C.3Okeke Ugochuhwu S.4Ezeja Maxwell I.5Omeh Yusuf N.6Asuzu Isaac U.7Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, NigeriaDepartment of Veterinary Pathology, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, NigeriaDepartment of Biological Sciences, Clifford University, Owerrinta, Abia State, NigeriaDepartment of Biochemistry, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, NigeriaDepartment of Biochemistry, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, NigeriaDepartment of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, NigeriaDepartment of Biochemistry, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, NigeriaDepartment of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, 410001 Enugu State, NigeriaThis study evaluated the hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats. The extract of P. pinnata root-bark was prepared using a cold maceration method with 80% methanol and concentrated at 40°C in hot air oven. The extract was administered once daily per os at 50, 100 and 200 mg/kg for 21 consecutive days. Distilled water (5 mL/kg) and glibenclamide (2 mg/kg) were used as the vehicle and reference standard, respectively. The serum lipid profile, markers of liver and kidney functions, antioxidant status (malondialdehyde level, superoxide dismutase and catalase activities), histopathological changes in liver and kidney were examined 24h after the last treatment on day 21. The extract reduced serum lipid profile, markers of liver and kidney functions of treated rats relative to vehicle-treated rats. The superoxide dismutase and catalase activities of the extract treated rats were also elevated relative to the vehicle-treated rats. The extract reversed liver and kidney injuries induced by alloxan in the treated rats. This study provides some basic information which suggest that P. pinnata could be effective in managing diabetic complications.https://doi.org/10.2478/cipms-2019-0023antioxidantpaullinia pinnatahepatoprotectivenephroprotectivelipid profile |
| spellingShingle | Onoja Samuel O. Daniel-Igwe Gloria Ejiofor Emmanuel Mbakwe Christiana C. Okeke Ugochuhwu S. Ezeja Maxwell I. Omeh Yusuf N. Asuzu Isaac U. Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats Current Issues in Pharmacy and Medical Sciences antioxidant paullinia pinnata hepatoprotective nephroprotective lipid profile |
| title | Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats |
| title_full | Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats |
| title_fullStr | Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats |
| title_full_unstemmed | Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats |
| title_short | Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats |
| title_sort | hypolipidemic hepatoprotective nephroprotective and anti lipid peroxidation properties of a methanol extract of paullinia pinnata root bark in alloxan induced hyperglycemic rats |
| topic | antioxidant paullinia pinnata hepatoprotective nephroprotective lipid profile |
| url | https://doi.org/10.2478/cipms-2019-0023 |
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