Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects
Glioblastoma (GBM) is the most aggressive primary brain tumour. As GBM incidence is associated with age, elderly people represent a consistent subgroup of patients. Elderly people with GBM show dismal prognosis (about 6 months) and limited response to treatments. Age is a negative prognostic factor,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/3/644 |
| _version_ | 1797472656779378688 |
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| author | Francesco Bruno Alessia Pellerino Rosa Palmiero Luca Bertero Cristina Mantovani Diego Garbossa Riccardo Soffietti Roberta Rudà |
| author_facet | Francesco Bruno Alessia Pellerino Rosa Palmiero Luca Bertero Cristina Mantovani Diego Garbossa Riccardo Soffietti Roberta Rudà |
| author_sort | Francesco Bruno |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most aggressive primary brain tumour. As GBM incidence is associated with age, elderly people represent a consistent subgroup of patients. Elderly people with GBM show dismal prognosis (about 6 months) and limited response to treatments. Age is a negative prognostic factor, which correlates with clinical frailty, poorer tolerability to surgery or adjuvant radio-chemotherapy, and higher occurrence of comorbidities and/or secondary complications. The aim of this paper is to review the clinical and molecular characteristics, current therapeutic options, and prognostic factors of elderly patients with GBM. |
| first_indexed | 2024-03-09T20:05:29Z |
| format | Article |
| id | doaj.art-129b121eeef94f29af02bbb93dab520e |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:05:29Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-129b121eeef94f29af02bbb93dab520e2023-11-24T00:33:14ZengMDPI AGBiomedicines2227-90592022-03-0110364410.3390/biomedicines10030644Glioblastoma in the Elderly: Review of Molecular and Therapeutic AspectsFrancesco Bruno0Alessia Pellerino1Rosa Palmiero2Luca Bertero3Cristina Mantovani4Diego Garbossa5Riccardo Soffietti6Roberta Rudà7Division of Neuro-Oncology, Department of Neuroscience, University and City of Health and Science, 10126 Turin, ItalyDivision of Neuro-Oncology, Department of Neuroscience, University and City of Health and Science, 10126 Turin, ItalyDivision of Neuro-Oncology, Department of Neuroscience, University and City of Health and Science, 10126 Turin, ItalyPathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyDivision of Radiotherapy, Department of Oncology, University and City of Health and Science, 10126 Turin, ItalyDivision of Neurosurgery, Department of Neuroscience, University and City of Health and Science, 10126 Turin, ItalyDivision of Neuro-Oncology, Department of Neuroscience, University and City of Health and Science, 10126 Turin, ItalyDivision of Neuro-Oncology, Department of Neuroscience, University and City of Health and Science, 10126 Turin, ItalyGlioblastoma (GBM) is the most aggressive primary brain tumour. As GBM incidence is associated with age, elderly people represent a consistent subgroup of patients. Elderly people with GBM show dismal prognosis (about 6 months) and limited response to treatments. Age is a negative prognostic factor, which correlates with clinical frailty, poorer tolerability to surgery or adjuvant radio-chemotherapy, and higher occurrence of comorbidities and/or secondary complications. The aim of this paper is to review the clinical and molecular characteristics, current therapeutic options, and prognostic factors of elderly patients with GBM.https://www.mdpi.com/2227-9059/10/3/644glioblastomaelderly patientsmolecular factorsprognostic factorscomprehensive geriatric assessment |
| spellingShingle | Francesco Bruno Alessia Pellerino Rosa Palmiero Luca Bertero Cristina Mantovani Diego Garbossa Riccardo Soffietti Roberta Rudà Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects Biomedicines glioblastoma elderly patients molecular factors prognostic factors comprehensive geriatric assessment |
| title | Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects |
| title_full | Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects |
| title_fullStr | Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects |
| title_full_unstemmed | Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects |
| title_short | Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects |
| title_sort | glioblastoma in the elderly review of molecular and therapeutic aspects |
| topic | glioblastoma elderly patients molecular factors prognostic factors comprehensive geriatric assessment |
| url | https://www.mdpi.com/2227-9059/10/3/644 |
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