Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma
Pinggui Chen,1 Yaoxuan Li,2 Yunyan Dai,1 Zhiming Wang,1 Yunpeng Zhou,1 Yi Wang,1 Gaopeng Li1 1Department of Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, People’s Republic of China; 2Department of Sc...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-03-01
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| Series: | Journal of Hepatocellular Carcinoma |
| Subjects: | |
| Online Access: | https://www.dovepress.com/advances-in-the-pathogenesis-of-metabolic-liver-disease-related-hepato-peer-reviewed-fulltext-article-JHC |
| _version_ | 1827314223511764992 |
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| author | Chen P Li Y Dai Y Wang Z Zhou Y Wang Y Li G |
| author_facet | Chen P Li Y Dai Y Wang Z Zhou Y Wang Y Li G |
| author_sort | Chen P |
| collection | DOAJ |
| description | Pinggui Chen,1 Yaoxuan Li,2 Yunyan Dai,1 Zhiming Wang,1 Yunpeng Zhou,1 Yi Wang,1 Gaopeng Li1 1Department of Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, People’s Republic of China; 2Department of School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Gaopeng Li, Email malone2001@163.comAbstract: Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and the primary cause of death in cancer cases, with significant public health concern worldwide. Despite the overall decline in the incidence and mortality rates of HCC in recent years in recent years, the emergence of metabolic liver disease-related HCC is causing heightened concern, especially in countries like the United States, the United Kingdom, and P.R. China. The escalation of metabolic liver disease-related HCC is attributed to a combination of factors, including genetic predisposition, lifestyle choices, and changes in the living environment. However, the pathogenesis of metabolic liver disease-associated HCC remains imperfect. In this review, we encapsulate the latest advances and essential aspects of the pathogenesis of metabolic liver disease-associated HCC, including alcoholic liver disease (ALD), metabolic dysfunction–associated steatotic liver disease (MASLD), and inherited metabolic liver diseases.Keywords: hepatocellular carcinoma, metabolic liver disease, pathogenesis, alcoholic liver disease, metabolic dysfunction–associated steatotic liver disease |
| first_indexed | 2024-04-24T22:31:12Z |
| format | Article |
| id | doaj.art-129b726403f044c1b7c6ca64c814fa57 |
| institution | Directory Open Access Journal |
| issn | 2253-5969 |
| language | English |
| last_indexed | 2024-04-24T22:31:12Z |
| publishDate | 2024-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Hepatocellular Carcinoma |
| spelling | doaj.art-129b726403f044c1b7c6ca64c814fa572024-03-19T17:12:19ZengDove Medical PressJournal of Hepatocellular Carcinoma2253-59692024-03-01Volume 1158159491356Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular CarcinomaChen PLi YDai YWang ZZhou YWang YLi GPinggui Chen,1 Yaoxuan Li,2 Yunyan Dai,1 Zhiming Wang,1 Yunpeng Zhou,1 Yi Wang,1 Gaopeng Li1 1Department of Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, People’s Republic of China; 2Department of School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Gaopeng Li, Email malone2001@163.comAbstract: Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and the primary cause of death in cancer cases, with significant public health concern worldwide. Despite the overall decline in the incidence and mortality rates of HCC in recent years in recent years, the emergence of metabolic liver disease-related HCC is causing heightened concern, especially in countries like the United States, the United Kingdom, and P.R. China. The escalation of metabolic liver disease-related HCC is attributed to a combination of factors, including genetic predisposition, lifestyle choices, and changes in the living environment. However, the pathogenesis of metabolic liver disease-associated HCC remains imperfect. In this review, we encapsulate the latest advances and essential aspects of the pathogenesis of metabolic liver disease-associated HCC, including alcoholic liver disease (ALD), metabolic dysfunction–associated steatotic liver disease (MASLD), and inherited metabolic liver diseases.Keywords: hepatocellular carcinoma, metabolic liver disease, pathogenesis, alcoholic liver disease, metabolic dysfunction–associated steatotic liver diseasehttps://www.dovepress.com/advances-in-the-pathogenesis-of-metabolic-liver-disease-related-hepato-peer-reviewed-fulltext-article-JHChepatocellular carcinomametabolic liver diseasepathogenesisalcoholic liver diseasemetabolic dysfunction–associated steatotic liver disease |
| spellingShingle | Chen P Li Y Dai Y Wang Z Zhou Y Wang Y Li G Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma Journal of Hepatocellular Carcinoma hepatocellular carcinoma metabolic liver disease pathogenesis alcoholic liver disease metabolic dysfunction–associated steatotic liver disease |
| title | Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma |
| title_full | Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma |
| title_fullStr | Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma |
| title_full_unstemmed | Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma |
| title_short | Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma |
| title_sort | advances in the pathogenesis of metabolic liver disease related hepatocellular carcinoma |
| topic | hepatocellular carcinoma metabolic liver disease pathogenesis alcoholic liver disease metabolic dysfunction–associated steatotic liver disease |
| url | https://www.dovepress.com/advances-in-the-pathogenesis-of-metabolic-liver-disease-related-hepato-peer-reviewed-fulltext-article-JHC |
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