Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development

Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development

Abstract Background Reactive oxygen species (ROS)-induced oxidative stress is well known to play a major role in male infertility. Sperm are sensitive to ROS damaging effects because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage. However, how oxidative...

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Bibliographic Details
Main Authors: Sarah Wyck, Carolina Herrera, Cristina E. Requena, Lilli Bittner, Petra Hajkova, Heinrich Bollwein, Raffaella Santoro
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Epigenetics & Chromatin
Subjects:
Oxidative stress
Epigenetic reprogramming
BER
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s13072-018-0224-y

Internet

http://link.springer.com/article/10.1186/s13072-018-0224-y

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