Memory and relatedness of transcriptional activity in mammalian cell lineages
Phenotypically identical mammalian cells often display considerable variability in transcript levels of individual genes. Here the authors document how different genes propagate their expression levels in cell lineages and suggest a potential role of transcriptional memory for generating spatial pat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09189-8 |
| _version_ | 1818405445632524288 |
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| author | Nicholas E. Phillips Aleksandra Mandic Saeed Omidi Felix Naef David M. Suter |
| author_facet | Nicholas E. Phillips Aleksandra Mandic Saeed Omidi Felix Naef David M. Suter |
| author_sort | Nicholas E. Phillips |
| collection | DOAJ |
| description | Phenotypically identical mammalian cells often display considerable variability in transcript levels of individual genes. Here the authors document how different genes propagate their expression levels in cell lineages and suggest a potential role of transcriptional memory for generating spatial patterns of gene expression. |
| first_indexed | 2024-12-14T08:56:10Z |
| format | Article |
| id | doaj.art-129c79e594114d3db8f9415be1533700 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:56:10Z |
| publishDate | 2019-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-129c79e594114d3db8f9415be15337002022-12-21T23:08:56ZengNature PortfolioNature Communications2041-17232019-03-0110111210.1038/s41467-019-09189-8Memory and relatedness of transcriptional activity in mammalian cell lineagesNicholas E. Phillips0Aleksandra Mandic1Saeed Omidi2Felix Naef3David M. Suter4Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de LausanneInstitute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de LausanneInstitute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de LausanneInstitute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de LausanneInstitute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de LausannePhenotypically identical mammalian cells often display considerable variability in transcript levels of individual genes. Here the authors document how different genes propagate their expression levels in cell lineages and suggest a potential role of transcriptional memory for generating spatial patterns of gene expression.https://doi.org/10.1038/s41467-019-09189-8 |
| spellingShingle | Nicholas E. Phillips Aleksandra Mandic Saeed Omidi Felix Naef David M. Suter Memory and relatedness of transcriptional activity in mammalian cell lineages Nature Communications |
| title | Memory and relatedness of transcriptional activity in mammalian cell lineages |
| title_full | Memory and relatedness of transcriptional activity in mammalian cell lineages |
| title_fullStr | Memory and relatedness of transcriptional activity in mammalian cell lineages |
| title_full_unstemmed | Memory and relatedness of transcriptional activity in mammalian cell lineages |
| title_short | Memory and relatedness of transcriptional activity in mammalian cell lineages |
| title_sort | memory and relatedness of transcriptional activity in mammalian cell lineages |
| url | https://doi.org/10.1038/s41467-019-09189-8 |
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