Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells
Hippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses the GABA/glycine vesicular transporters (VIAAT) and the atypical type III vesicular glutamate transporter (VGLUT3...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-05-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fncel.2017.00140/full |
| _version_ | 1819137175808114688 |
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| author | Caroline Fasano Jill Rocchetti Katarzyna Pietrajtis Johannes-Friedrich Zander Frédéric Manseau Diana Y. Sakae Maya Marcus-Sells Lauriane Ramet Lydie J. Morel Damien Carrel Sylvie Dumas Susanne Bolte Véronique Bernard Erika Vigneault Romain Goutagny Gudrun Ahnert-Hilger Bruno Giros Bruno Giros Stéphanie Daumas Sylvain Williams Salah El Mestikawy Salah El Mestikawy |
| author_facet | Caroline Fasano Jill Rocchetti Katarzyna Pietrajtis Johannes-Friedrich Zander Frédéric Manseau Diana Y. Sakae Maya Marcus-Sells Lauriane Ramet Lydie J. Morel Damien Carrel Sylvie Dumas Susanne Bolte Véronique Bernard Erika Vigneault Romain Goutagny Gudrun Ahnert-Hilger Bruno Giros Bruno Giros Stéphanie Daumas Sylvain Williams Salah El Mestikawy Salah El Mestikawy |
| author_sort | Caroline Fasano |
| collection | DOAJ |
| description | Hippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses the GABA/glycine vesicular transporters (VIAAT) and the atypical type III vesicular glutamate transporter (VGLUT3); therefore, these cells have the ability to signal with both GABA and glutamate. GABAergic transmission by basket cells has been extensively characterized but nothing is known about the functional implications of VGLUT3-dependent glutamate released by these cells. Here, using VGLUT3-null mice we observed that the loss of VGLUT3 results in a metaplastic shift in synaptic plasticity at Shaeffer’s collaterals – CA1 synapses and an altered theta oscillation. These changes were paralleled by the loss of a VGLUT3-dependent inhibition of GABAergic current in CA1 pyramidal layer. Therefore presynaptic type III metabotropic could be activated by glutamate released from VGLUT3-positive interneurons. This putative presynaptic heterologous feedback mechanism inhibits local GABAergic tone and regulates the hippocampal neuronal network. |
| first_indexed | 2024-12-22T10:46:42Z |
| format | Article |
| id | doaj.art-129d07f0b5a44664b56ac9b5dcd7bb5d |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-22T10:46:42Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-129d07f0b5a44664b56ac9b5dcd7bb5d2022-12-21T18:28:54ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022017-05-011110.3389/fncel.2017.00140258170Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket CellsCaroline Fasano0Jill Rocchetti1Katarzyna Pietrajtis2Johannes-Friedrich Zander3Frédéric Manseau4Diana Y. Sakae5Maya Marcus-Sells6Lauriane Ramet7Lydie J. Morel8Damien Carrel9Sylvie Dumas10Susanne Bolte11Véronique Bernard12Erika Vigneault13Romain Goutagny14Gudrun Ahnert-Hilger15Bruno Giros16Bruno Giros17Stéphanie Daumas18Sylvain Williams19Salah El Mestikawy20Salah El Mestikawy21Douglas Mental Health University Institute, Department of Psychiatry, McGill University, MontrealQC, CanadaDouglas Mental Health University Institute, Department of Psychiatry, McGill University, MontrealQC, CanadaDouglas Mental Health University Institute, Department of Psychiatry, McGill University, MontrealQC, CanadaInstitut für Integrative Neuroanatomie Research CenterBerlin, GermanyDouglas Mental Health University Institute, Department of Psychiatry, McGill University, MontrealQC, CanadaSorbonne Universités, UPMC Univ Paris 06, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Medicale, Institut de Biologie Paris Seine, Neuroscience Paris Seine (NPS)Paris, FranceDouglas Mental Health University Institute, Department of Psychiatry, McGill University, MontrealQC, CanadaSorbonne Universités, UPMC Univ Paris 06, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Medicale, Institut de Biologie Paris Seine, Neuroscience Paris Seine (NPS)Paris, FranceSorbonne Universités, UPMC Univ Paris 06, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Medicale, Institut de Biologie Paris Seine, Neuroscience Paris Seine (NPS)Paris, FranceUniversité Paris Descartes, Sorbonne Paris Cité, Centre National de la Recherche Scientifique, UMR 8250Paris, FranceOramacellParis, FranceSorbonne Universités, UPMC Univ Paris 06, CNRS, Core Facilities - Institut de Biologie Paris SeineParis, FranceSorbonne Universités, UPMC Univ Paris 06, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Medicale, Institut de Biologie Paris Seine, Neuroscience Paris Seine (NPS)Paris, FranceDouglas Mental Health University Institute, Department of Psychiatry, McGill University, MontrealQC, CanadaCNRS UMR 7364, Team NCD, Université de StrasbourgStrasbourg, FranceInstitut für Integrative Neuroanatomie Research CenterBerlin, GermanyDouglas Mental Health University Institute, Department of Psychiatry, McGill University, MontrealQC, CanadaSorbonne Universités, UPMC Univ Paris 06, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Medicale, Institut de Biologie Paris Seine, Neuroscience Paris Seine (NPS)Paris, FranceSorbonne Universités, UPMC Univ Paris 06, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Medicale, Institut de Biologie Paris Seine, Neuroscience Paris Seine (NPS)Paris, FranceDouglas Mental Health University Institute, Department of Psychiatry, McGill University, MontrealQC, CanadaDouglas Mental Health University Institute, Department of Psychiatry, McGill University, MontrealQC, CanadaSorbonne Universités, UPMC Univ Paris 06, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Medicale, Institut de Biologie Paris Seine, Neuroscience Paris Seine (NPS)Paris, FranceHippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses the GABA/glycine vesicular transporters (VIAAT) and the atypical type III vesicular glutamate transporter (VGLUT3); therefore, these cells have the ability to signal with both GABA and glutamate. GABAergic transmission by basket cells has been extensively characterized but nothing is known about the functional implications of VGLUT3-dependent glutamate released by these cells. Here, using VGLUT3-null mice we observed that the loss of VGLUT3 results in a metaplastic shift in synaptic plasticity at Shaeffer’s collaterals – CA1 synapses and an altered theta oscillation. These changes were paralleled by the loss of a VGLUT3-dependent inhibition of GABAergic current in CA1 pyramidal layer. Therefore presynaptic type III metabotropic could be activated by glutamate released from VGLUT3-positive interneurons. This putative presynaptic heterologous feedback mechanism inhibits local GABAergic tone and regulates the hippocampal neuronal network.http://journal.frontiersin.org/article/10.3389/fncel.2017.00140/fullhippocampusbasket cellvesicular glutamate transporter type 3glutamate/GABA co-transmissiontype III mGluRs |
| spellingShingle | Caroline Fasano Jill Rocchetti Katarzyna Pietrajtis Johannes-Friedrich Zander Frédéric Manseau Diana Y. Sakae Maya Marcus-Sells Lauriane Ramet Lydie J. Morel Damien Carrel Sylvie Dumas Susanne Bolte Véronique Bernard Erika Vigneault Romain Goutagny Gudrun Ahnert-Hilger Bruno Giros Bruno Giros Stéphanie Daumas Sylvain Williams Salah El Mestikawy Salah El Mestikawy Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells Frontiers in Cellular Neuroscience hippocampus basket cell vesicular glutamate transporter type 3 glutamate/GABA co-transmission type III mGluRs |
| title | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
| title_full | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
| title_fullStr | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
| title_full_unstemmed | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
| title_short | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
| title_sort | regulation of the hippocampal network by vglut3 positive cck gabaergic basket cells |
| topic | hippocampus basket cell vesicular glutamate transporter type 3 glutamate/GABA co-transmission type III mGluRs |
| url | http://journal.frontiersin.org/article/10.3389/fncel.2017.00140/full |
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