An <i>Acinetobacter</i> non-<i>baumannii</i> Population Study: Antimicrobial Resistance Genes (ARGs)
<em>Acinetobacter </em>non-<em>baumannii</em> species are becoming common etiologic agents of nosocomial infections. Furthermore, clinical isolates belonging to this group of bacteria are usually resistant to one or more antibiotics. The current information about antibiotic r...
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MDPI AG
2020-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/1/16 |
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| author | Adam Baraka German M. Traglia Sabrina Montaña Marcelo E. Tolmasky Maria Soledad Ramirez |
| author_facet | Adam Baraka German M. Traglia Sabrina Montaña Marcelo E. Tolmasky Maria Soledad Ramirez |
| author_sort | Adam Baraka |
| collection | DOAJ |
| description | <em>Acinetobacter </em>non-<em>baumannii</em> species are becoming common etiologic agents of nosocomial infections. Furthermore, clinical isolates belonging to this group of bacteria are usually resistant to one or more antibiotics. The current information about antibiotic resistance genes in the different <em>A. </em>non-<em>baumannii</em> species has not yet been studied as a whole. Therefore, we did a comparative study of the resistomes of <em>A. </em>non-<em>baumannii</em> pathogens based on information available in published articles and genome sequences. We searched the available literature and sequences deposited in GenBank to identify the resistance gene content of <em>A. calcoaceticus</em>, <em>A. lwoffii</em>, <em>A. junii</em>,<em> A. soli</em>,<em> A. ursingii</em>,<em> A. bereziniae</em>,<em> A. nosocomialis</em>,<em> A. portensis</em>, <em>A. guerrae</em>,<em> A. baylyi</em>, <em>A. calcoaceticus</em>, <em>A. disperses</em>, <em>A. johnsonii</em>, <em>A. junii</em>, <em>A. lwoffii</em>,<em> A. nosocomialis</em>,<em> A. oleivorans</em>,<em> A. oryzae</em>,<em> A. pittii</em>,<em> A. radioresistens</em>, and<em> A. venetianus. </em>The most common genes were those coding for different β-lactamases, including the carbapenemase genes <em>bla</em><sub>NDM-1 </sub>and <em>bla</em><sub>OXA-58</sub>. <em>A. pittii</em> was the species with the most β-lactamase resistance genes reported. Other genes that were commonly found include those encoding some aminoglycoside modifying enzymes, the most common being <em>aph(6)-Id</em>,<em> ant(3″)-IIa</em>, and<em> aph(3″)-Ib</em>, and efflux pumps. All or part of the genes coding for the AdeABC, AdeFGH, and AdeIJK efflux pumps were the most commonly found. This article incorporates all the current information about <em>A.</em> non-<em>baumannii </em>resistance genes. The comparison of the different resistomes shows that there are similarities in the genes present, but there are also significant differences that could impact the efficiency of treatments depending on the etiologic agent. This article is a comprehensive resource about <em>A.</em> non-<em>baumannii </em>resistomes. |
| first_indexed | 2024-03-10T13:45:09Z |
| format | Article |
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| institution | Directory Open Access Journal |
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| last_indexed | 2024-03-10T13:45:09Z |
| publishDate | 2020-12-01 |
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| series | Antibiotics |
| spelling | doaj.art-129e6cc383c345f9b4a22a596db5393c2023-11-21T02:41:09ZengMDPI AGAntibiotics2079-63822020-12-011011610.3390/antibiotics10010016An <i>Acinetobacter</i> non-<i>baumannii</i> Population Study: Antimicrobial Resistance Genes (ARGs)Adam Baraka0German M. Traglia1Sabrina Montaña2Marcelo E. Tolmasky3Maria Soledad Ramirez4Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA 92831, USADepartamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República, MVD, Montevideo 11800, UruguayLaboratorio de Bacteriología Clínica, Departamento de Bioquímica Clínica, Hospital de Clínicas José de San Martín, Facultad de Farmacia y Bioquímica, Buenos Aires 1120, ArgentinaCenter for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA 92831, USACenter for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA 92831, USA<em>Acinetobacter </em>non-<em>baumannii</em> species are becoming common etiologic agents of nosocomial infections. Furthermore, clinical isolates belonging to this group of bacteria are usually resistant to one or more antibiotics. The current information about antibiotic resistance genes in the different <em>A. </em>non-<em>baumannii</em> species has not yet been studied as a whole. Therefore, we did a comparative study of the resistomes of <em>A. </em>non-<em>baumannii</em> pathogens based on information available in published articles and genome sequences. We searched the available literature and sequences deposited in GenBank to identify the resistance gene content of <em>A. calcoaceticus</em>, <em>A. lwoffii</em>, <em>A. junii</em>,<em> A. soli</em>,<em> A. ursingii</em>,<em> A. bereziniae</em>,<em> A. nosocomialis</em>,<em> A. portensis</em>, <em>A. guerrae</em>,<em> A. baylyi</em>, <em>A. calcoaceticus</em>, <em>A. disperses</em>, <em>A. johnsonii</em>, <em>A. junii</em>, <em>A. lwoffii</em>,<em> A. nosocomialis</em>,<em> A. oleivorans</em>,<em> A. oryzae</em>,<em> A. pittii</em>,<em> A. radioresistens</em>, and<em> A. venetianus. </em>The most common genes were those coding for different β-lactamases, including the carbapenemase genes <em>bla</em><sub>NDM-1 </sub>and <em>bla</em><sub>OXA-58</sub>. <em>A. pittii</em> was the species with the most β-lactamase resistance genes reported. Other genes that were commonly found include those encoding some aminoglycoside modifying enzymes, the most common being <em>aph(6)-Id</em>,<em> ant(3″)-IIa</em>, and<em> aph(3″)-Ib</em>, and efflux pumps. All or part of the genes coding for the AdeABC, AdeFGH, and AdeIJK efflux pumps were the most commonly found. This article incorporates all the current information about <em>A.</em> non-<em>baumannii </em>resistance genes. The comparison of the different resistomes shows that there are similarities in the genes present, but there are also significant differences that could impact the efficiency of treatments depending on the etiologic agent. This article is a comprehensive resource about <em>A.</em> non-<em>baumannii </em>resistomes.https://www.mdpi.com/2079-6382/10/1/16<i>Acinetobacter</i> non-<i>baumannii</i>antimicrobial resistanceresistome |
| spellingShingle | Adam Baraka German M. Traglia Sabrina Montaña Marcelo E. Tolmasky Maria Soledad Ramirez An <i>Acinetobacter</i> non-<i>baumannii</i> Population Study: Antimicrobial Resistance Genes (ARGs) Antibiotics <i>Acinetobacter</i> non-<i>baumannii</i> antimicrobial resistance resistome |
| title | An <i>Acinetobacter</i> non-<i>baumannii</i> Population Study: Antimicrobial Resistance Genes (ARGs) |
| title_full | An <i>Acinetobacter</i> non-<i>baumannii</i> Population Study: Antimicrobial Resistance Genes (ARGs) |
| title_fullStr | An <i>Acinetobacter</i> non-<i>baumannii</i> Population Study: Antimicrobial Resistance Genes (ARGs) |
| title_full_unstemmed | An <i>Acinetobacter</i> non-<i>baumannii</i> Population Study: Antimicrobial Resistance Genes (ARGs) |
| title_short | An <i>Acinetobacter</i> non-<i>baumannii</i> Population Study: Antimicrobial Resistance Genes (ARGs) |
| title_sort | i acinetobacter i non i baumannii i population study antimicrobial resistance genes args |
| topic | <i>Acinetobacter</i> non-<i>baumannii</i> antimicrobial resistance resistome |
| url | https://www.mdpi.com/2079-6382/10/1/16 |
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