A lentiviral sponge for miR-101 regulates RanBP9 expression and amyloid precursor protein metabolism in hippocampal neurons

A lentiviral sponge for miR-101 regulates RanBP9 expression and amyloid precursor protein metabolism in hippocampal neurons

Neurodegeneration associated with amyloid β (Aβ) peptide accumulation, synaptic loss, and memory impairment are pathophysiological features of Alzheimer's disease (AD). Numerous microRNAs regulate amyloid precursor protein (APP) expression and metabolism. We previously reported that miR-101 is...

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Bibliographic Details
Main Authors: Christian eBarbato, Silvia ePezzola, Cinzia eCaggiano, Martina eAntonelli, Paola eFrisone, Maria Teresa eCiotti, Francesca eRuberti
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer's disease
microRNA
amyloid precursor protein
miR-101
Ran-binding protein 9
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00037/full

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