Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb.
The recent history of activity input onto granule cells (GCs) in the main olfactory bulb can affect the strength of lateral inhibition, which functions to generate contrast enhancement. However, at the plasticity level, it is unknown whether and how the prior modification of lateral inhibition modul...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3334975?pdf=render |
| _version_ | 1828484031692406784 |
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| author | Teng-Fei Ma Xiao-Lei Zhao Lei Cai Nan Zhang Si-Qiang Ren Fang Ji Tian Tian Wei Lu |
| author_facet | Teng-Fei Ma Xiao-Lei Zhao Lei Cai Nan Zhang Si-Qiang Ren Fang Ji Tian Tian Wei Lu |
| author_sort | Teng-Fei Ma |
| collection | DOAJ |
| description | The recent history of activity input onto granule cells (GCs) in the main olfactory bulb can affect the strength of lateral inhibition, which functions to generate contrast enhancement. However, at the plasticity level, it is unknown whether and how the prior modification of lateral inhibition modulates the subsequent induction of long-lasting changes of the excitatory olfactory nerve (ON) inputs to mitral cells (MCs). Here we found that the repetitive stimulation of two distinct excitatory inputs to the GCs induced a persistent modification of lateral inhibition in MCs in opposing directions. This bidirectional modification of inhibitory inputs differentially regulated the subsequent synaptic plasticity of the excitatory ON inputs to the MCs, which was induced by the repetitive pairing of excitatory postsynaptic potentials (EPSPs) with postsynaptic bursts. The regulation of spike timing-dependent plasticity (STDP) was achieved by the regulation of the inter-spike-interval (ISI) of the postsynaptic bursts. This novel form of inhibition-dependent regulation of plasticity may contribute to the encoding or processing of olfactory information in the olfactory bulb. |
| first_indexed | 2024-12-11T08:48:56Z |
| format | Article |
| id | doaj.art-129f28c7ff4c49d8843a94b150fdb9bf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T08:48:56Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-129f28c7ff4c49d8843a94b150fdb9bf2022-12-22T01:14:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3500110.1371/journal.pone.0035001Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb.Teng-Fei MaXiao-Lei ZhaoLei CaiNan ZhangSi-Qiang RenFang JiTian TianWei LuThe recent history of activity input onto granule cells (GCs) in the main olfactory bulb can affect the strength of lateral inhibition, which functions to generate contrast enhancement. However, at the plasticity level, it is unknown whether and how the prior modification of lateral inhibition modulates the subsequent induction of long-lasting changes of the excitatory olfactory nerve (ON) inputs to mitral cells (MCs). Here we found that the repetitive stimulation of two distinct excitatory inputs to the GCs induced a persistent modification of lateral inhibition in MCs in opposing directions. This bidirectional modification of inhibitory inputs differentially regulated the subsequent synaptic plasticity of the excitatory ON inputs to the MCs, which was induced by the repetitive pairing of excitatory postsynaptic potentials (EPSPs) with postsynaptic bursts. The regulation of spike timing-dependent plasticity (STDP) was achieved by the regulation of the inter-spike-interval (ISI) of the postsynaptic bursts. This novel form of inhibition-dependent regulation of plasticity may contribute to the encoding or processing of olfactory information in the olfactory bulb.http://europepmc.org/articles/PMC3334975?pdf=render |
| spellingShingle | Teng-Fei Ma Xiao-Lei Zhao Lei Cai Nan Zhang Si-Qiang Ren Fang Ji Tian Tian Wei Lu Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb. PLoS ONE |
| title | Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb. |
| title_full | Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb. |
| title_fullStr | Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb. |
| title_full_unstemmed | Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb. |
| title_short | Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb. |
| title_sort | regulation of spike timing dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb |
| url | http://europepmc.org/articles/PMC3334975?pdf=render |
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