The Role of Surgery for Oligometastatic Non-Small Cell Lung Cancer
Oligometastatic non-small cell lung cancer (NSCLC) is metastatic disease that refers to a limited number of metastatic sites. It is analogous to an intermediate stage of NSCLC, between localized and widely metastatic disease, even though no staging criteria establishes this distinction. Oligometasta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/10/2524 |
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| author | Caleb J. Euhus Taylor R. Ripley Cristian G. Medina |
| author_facet | Caleb J. Euhus Taylor R. Ripley Cristian G. Medina |
| author_sort | Caleb J. Euhus |
| collection | DOAJ |
| description | Oligometastatic non-small cell lung cancer (NSCLC) is metastatic disease that refers to a limited number of metastatic sites. It is analogous to an intermediate stage of NSCLC, between localized and widely metastatic disease, even though no staging criteria establishes this distinction. Oligometastatic NSCLC describes a patient subgroup with limited metastasis to one or a few organs. These patients seem to have a more indolent cancer than those with diffuse metastasis. For these select patients with oligometastatic disease, the use of palliative systemic therapy over local aggressive treatment may be a missed opportunity to improve survival. The clear definition of this subgroup and identification of the best treatment remains the current challenge in the management of the disease. Surgery was the early cornerstone in the treatment of limited disease; however, as modalities such as chemotherapy, stereotactic radiosurgery, and immunotherapy have matured, the role of excision is less clearly defined. There are sparse randomized controlled trials comparing the efficacy of different treatment modalities in patients with oligometastatic NSCLC. However, there is a growing body of retrospective research detailing the prognostic factors that characterize the role of surgery in the management of these patients. This article clarifies the context and definition of the term oligometastatic, as it applies to NSCLC, and reviews the current results in the use of surgery for its management. |
| first_indexed | 2024-03-10T03:11:16Z |
| format | Article |
| id | doaj.art-12a21ef762184d51b39290db10eca6d8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:11:16Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-12a21ef762184d51b39290db10eca6d82023-11-23T10:24:21ZengMDPI AGCancers2072-66942022-05-011410252410.3390/cancers14102524The Role of Surgery for Oligometastatic Non-Small Cell Lung CancerCaleb J. Euhus0Taylor R. Ripley1Cristian G. Medina2The Michael E. DeBakey Department of Surgery, Division of Thoracic Surgery, Baylor College of Medicine, 1 Moursund St., Houston, TX 77030, USAThe Michael E. DeBakey Department of Surgery, Division of Thoracic Surgery, Baylor College of Medicine, 1 Moursund St., Houston, TX 77030, USAThe Michael E. DeBakey Department of Surgery, Division of Thoracic Surgery, Baylor College of Medicine, 1 Moursund St., Houston, TX 77030, USAOligometastatic non-small cell lung cancer (NSCLC) is metastatic disease that refers to a limited number of metastatic sites. It is analogous to an intermediate stage of NSCLC, between localized and widely metastatic disease, even though no staging criteria establishes this distinction. Oligometastatic NSCLC describes a patient subgroup with limited metastasis to one or a few organs. These patients seem to have a more indolent cancer than those with diffuse metastasis. For these select patients with oligometastatic disease, the use of palliative systemic therapy over local aggressive treatment may be a missed opportunity to improve survival. The clear definition of this subgroup and identification of the best treatment remains the current challenge in the management of the disease. Surgery was the early cornerstone in the treatment of limited disease; however, as modalities such as chemotherapy, stereotactic radiosurgery, and immunotherapy have matured, the role of excision is less clearly defined. There are sparse randomized controlled trials comparing the efficacy of different treatment modalities in patients with oligometastatic NSCLC. However, there is a growing body of retrospective research detailing the prognostic factors that characterize the role of surgery in the management of these patients. This article clarifies the context and definition of the term oligometastatic, as it applies to NSCLC, and reviews the current results in the use of surgery for its management.https://www.mdpi.com/2072-6694/14/10/2524oligometastatic non-small cell lung cancermetastatic non-small cell lung cancerNSCLC historylung cancer stagingsurgery and NSCLClocal consolidative therapy (LCT) |
| spellingShingle | Caleb J. Euhus Taylor R. Ripley Cristian G. Medina The Role of Surgery for Oligometastatic Non-Small Cell Lung Cancer Cancers oligometastatic non-small cell lung cancer metastatic non-small cell lung cancer NSCLC history lung cancer staging surgery and NSCLC local consolidative therapy (LCT) |
| title | The Role of Surgery for Oligometastatic Non-Small Cell Lung Cancer |
| title_full | The Role of Surgery for Oligometastatic Non-Small Cell Lung Cancer |
| title_fullStr | The Role of Surgery for Oligometastatic Non-Small Cell Lung Cancer |
| title_full_unstemmed | The Role of Surgery for Oligometastatic Non-Small Cell Lung Cancer |
| title_short | The Role of Surgery for Oligometastatic Non-Small Cell Lung Cancer |
| title_sort | role of surgery for oligometastatic non small cell lung cancer |
| topic | oligometastatic non-small cell lung cancer metastatic non-small cell lung cancer NSCLC history lung cancer staging surgery and NSCLC local consolidative therapy (LCT) |
| url | https://www.mdpi.com/2072-6694/14/10/2524 |
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