Efficacy of Green Cerium Oxide Nanoparticles for Potential Therapeutic Applications: Circumstantial Insight on Mechanistic Aspects
Green synthesized cerium oxide nanoparticles (GS-CeO<sub>2</sub> NPs) have a unique size, shape, and biofunctional properties and are decorated with potential biocompatible agents to perform various therapeutic actions, such as antimicrobial, anticancer, antidiabetic, and antioxidant eff...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/12/2117 |
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| author | Maarij Khan Zia-ur-Rehman Mashwani Muhammad Ikram Naveed I. Raja Azza H. Mohamed Guogang Ren Ahmad A. Omar |
| author_facet | Maarij Khan Zia-ur-Rehman Mashwani Muhammad Ikram Naveed I. Raja Azza H. Mohamed Guogang Ren Ahmad A. Omar |
| author_sort | Maarij Khan |
| collection | DOAJ |
| description | Green synthesized cerium oxide nanoparticles (GS-CeO<sub>2</sub> NPs) have a unique size, shape, and biofunctional properties and are decorated with potential biocompatible agents to perform various therapeutic actions, such as antimicrobial, anticancer, antidiabetic, and antioxidant effects and drug delivery, by acquiring various mechanistic approaches at the molecular level. In this review article, we provide a detailed overview of some of these critical mechanisms, including DNA fragmentation, disruption of the electron transport chain, degradation of chromosomal assemblage, mitochondrial damage, inhibition of ATP synthase activity, inhibition of enzyme catalytic sites, disorganization, disruption, and lipid peroxidation of the cell membrane, and inhibition of various cellular pathways. This review article also provides up-to-date information about the future applications of GS-CeONPs to make breakthroughs in medical sectors for the advancement and precision of medicine and to effectively inform the disease diagnosis and treatment strategies. |
| first_indexed | 2024-03-09T22:51:58Z |
| format | Article |
| id | doaj.art-12a2c6986c71483197c661d0e53a6e5a |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T22:51:58Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-12a2c6986c71483197c661d0e53a6e5a2023-11-23T18:17:52ZengMDPI AGNanomaterials2079-49912022-06-011212211710.3390/nano12122117Efficacy of Green Cerium Oxide Nanoparticles for Potential Therapeutic Applications: Circumstantial Insight on Mechanistic AspectsMaarij Khan0Zia-ur-Rehman Mashwani1Muhammad Ikram2Naveed I. Raja3Azza H. Mohamed4Guogang Ren5Ahmad A. Omar6Department of Botany, PMAS Arid Agriculture University, Rawalpindi 46300, PakistanDepartment of Botany, PMAS Arid Agriculture University, Rawalpindi 46300, PakistanDepartment of Botany, PMAS Arid Agriculture University, Rawalpindi 46300, PakistanDepartment of Botany, PMAS Arid Agriculture University, Rawalpindi 46300, PakistanDepartment of Agricultural Chemistry, College of Agriculture, Mansoura University, Mansoura 35516, EgyptSchool of Physics, Engineering and Computer Science, University of Hertfordshire, Hatfield AL10 9AB, UKCitrus Research and Education Center, University of Florida (IFAS), Lake Alfred, FL 33850, USAGreen synthesized cerium oxide nanoparticles (GS-CeO<sub>2</sub> NPs) have a unique size, shape, and biofunctional properties and are decorated with potential biocompatible agents to perform various therapeutic actions, such as antimicrobial, anticancer, antidiabetic, and antioxidant effects and drug delivery, by acquiring various mechanistic approaches at the molecular level. In this review article, we provide a detailed overview of some of these critical mechanisms, including DNA fragmentation, disruption of the electron transport chain, degradation of chromosomal assemblage, mitochondrial damage, inhibition of ATP synthase activity, inhibition of enzyme catalytic sites, disorganization, disruption, and lipid peroxidation of the cell membrane, and inhibition of various cellular pathways. This review article also provides up-to-date information about the future applications of GS-CeONPs to make breakthroughs in medical sectors for the advancement and precision of medicine and to effectively inform the disease diagnosis and treatment strategies.https://www.mdpi.com/2079-4991/12/12/2117cerium metalcancerDNA fragmentationlipid peroxidationdrug deliverydiabetes |
| spellingShingle | Maarij Khan Zia-ur-Rehman Mashwani Muhammad Ikram Naveed I. Raja Azza H. Mohamed Guogang Ren Ahmad A. Omar Efficacy of Green Cerium Oxide Nanoparticles for Potential Therapeutic Applications: Circumstantial Insight on Mechanistic Aspects Nanomaterials cerium metal cancer DNA fragmentation lipid peroxidation drug delivery diabetes |
| title | Efficacy of Green Cerium Oxide Nanoparticles for Potential Therapeutic Applications: Circumstantial Insight on Mechanistic Aspects |
| title_full | Efficacy of Green Cerium Oxide Nanoparticles for Potential Therapeutic Applications: Circumstantial Insight on Mechanistic Aspects |
| title_fullStr | Efficacy of Green Cerium Oxide Nanoparticles for Potential Therapeutic Applications: Circumstantial Insight on Mechanistic Aspects |
| title_full_unstemmed | Efficacy of Green Cerium Oxide Nanoparticles for Potential Therapeutic Applications: Circumstantial Insight on Mechanistic Aspects |
| title_short | Efficacy of Green Cerium Oxide Nanoparticles for Potential Therapeutic Applications: Circumstantial Insight on Mechanistic Aspects |
| title_sort | efficacy of green cerium oxide nanoparticles for potential therapeutic applications circumstantial insight on mechanistic aspects |
| topic | cerium metal cancer DNA fragmentation lipid peroxidation drug delivery diabetes |
| url | https://www.mdpi.com/2079-4991/12/12/2117 |
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