Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation
Abstract The precise design of single-atom nanozymes (SAzymes) and understanding of their biocatalytic mechanisms hold great promise for developing ideal bio-enzyme substitutes. While considerable efforts have been directed towards mimicking partial bio-inspired structures, the integration of hetero...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-46528-w |
| _version_ | 1797259124707164160 |
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| author | Ying Wang Vinod K. Paidi Weizhen Wang Yong Wang Guangri Jia Tingyu Yan Xiaoqiang Cui Songhua Cai Jingxiang Zhao Kug-Seung Lee Lawrence Yoon Suk Lee Kwok-Yin Wong |
| author_facet | Ying Wang Vinod K. Paidi Weizhen Wang Yong Wang Guangri Jia Tingyu Yan Xiaoqiang Cui Songhua Cai Jingxiang Zhao Kug-Seung Lee Lawrence Yoon Suk Lee Kwok-Yin Wong |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | Abstract The precise design of single-atom nanozymes (SAzymes) and understanding of their biocatalytic mechanisms hold great promise for developing ideal bio-enzyme substitutes. While considerable efforts have been directed towards mimicking partial bio-inspired structures, the integration of heterogeneous SAzymes configurations and homogeneous enzyme-like mechanism remains an enormous challenge. Here, we show a spatial engineering strategy to fabricate dual-sites SAzymes with atomic Fe active center and adjacent Cu sites. Compared to planar Fe–Cu dual-atomic sites, vertically stacked Fe–Cu geometry in FePc@2D-Cu–N–C possesses highly optimized scaffolds, favorable substrate affinity, and fast electron transfer. These characteristics of FePc@2D-Cu–N–C SAzyme induces biomimetic O2 activation through homogenous enzymatic pathway, resembling functional and mechanistic similarity to natural cytochrome c oxidase. Furthermore, it presents an appealing alternative of cytochrome P450 3A4 for drug metabolism and drug–drug interaction. These findings are expected to deepen the fundamental understanding of atomic-level design in next-generation bio-inspired nanozymes. |
| first_indexed | 2024-04-24T23:04:27Z |
| format | Article |
| id | doaj.art-12a30d95a3ea441eb0ad34ef80ae7209 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T23:04:27Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-12a30d95a3ea441eb0ad34ef80ae72092024-03-17T12:31:50ZengNature PortfolioNature Communications2041-17232024-03-0115111310.1038/s41467-024-46528-wSpatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activationYing Wang0Vinod K. Paidi1Weizhen Wang2Yong Wang3Guangri Jia4Tingyu Yan5Xiaoqiang Cui6Songhua Cai7Jingxiang Zhao8Kug-Seung Lee9Lawrence Yoon Suk Lee10Kwok-Yin Wong11State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung HomEuropean Synchrotron Radiation FacilityDepartment of Applied Physics, The Hong Kong Polytechnic University, Hung HomState Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung HomState Key Laboratory of Automotive Simulation and Control, Department of Materials Science, Key Laboratory of Automobile Materials of MOE, Jilin UniversityKey Laboratory of Photonic and Electronic Bandgap Materials of MOE, College of Chemistry and Chemical Engineering, Harbin Normal UniversityState Key Laboratory of Automotive Simulation and Control, Department of Materials Science, Key Laboratory of Automobile Materials of MOE, Jilin UniversityDepartment of Applied Physics, The Hong Kong Polytechnic University, Hung HomKey Laboratory of Photonic and Electronic Bandgap Materials of MOE, College of Chemistry and Chemical Engineering, Harbin Normal UniversityPohang Accelerator Laboratory (PAL), Pohang University of Science and Technology (POSTECH)State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung HomState Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung HomAbstract The precise design of single-atom nanozymes (SAzymes) and understanding of their biocatalytic mechanisms hold great promise for developing ideal bio-enzyme substitutes. While considerable efforts have been directed towards mimicking partial bio-inspired structures, the integration of heterogeneous SAzymes configurations and homogeneous enzyme-like mechanism remains an enormous challenge. Here, we show a spatial engineering strategy to fabricate dual-sites SAzymes with atomic Fe active center and adjacent Cu sites. Compared to planar Fe–Cu dual-atomic sites, vertically stacked Fe–Cu geometry in FePc@2D-Cu–N–C possesses highly optimized scaffolds, favorable substrate affinity, and fast electron transfer. These characteristics of FePc@2D-Cu–N–C SAzyme induces biomimetic O2 activation through homogenous enzymatic pathway, resembling functional and mechanistic similarity to natural cytochrome c oxidase. Furthermore, it presents an appealing alternative of cytochrome P450 3A4 for drug metabolism and drug–drug interaction. These findings are expected to deepen the fundamental understanding of atomic-level design in next-generation bio-inspired nanozymes.https://doi.org/10.1038/s41467-024-46528-w |
| spellingShingle | Ying Wang Vinod K. Paidi Weizhen Wang Yong Wang Guangri Jia Tingyu Yan Xiaoqiang Cui Songhua Cai Jingxiang Zhao Kug-Seung Lee Lawrence Yoon Suk Lee Kwok-Yin Wong Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation Nature Communications |
| title | Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation |
| title_full | Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation |
| title_fullStr | Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation |
| title_full_unstemmed | Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation |
| title_short | Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation |
| title_sort | spatial engineering of single atom fe adjacent to cu assisted nanozymes for biomimetic o2 activation |
| url | https://doi.org/10.1038/s41467-024-46528-w |
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