The value of coordinated analysis of multimodal atherosclerotic plaque imaging in the assessment of cardiovascular and cerebrovascular events
BackgroundAlthough atherosclerosis (AS) can affect multiple vascular beds, previous studies have focused on the analysis of single-site AS plaques.ObjectiveThe aim of this study is to explore the differences or similarities in the characteristics of atherosclerotic plaque found in the internal carot...
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| Format: | Article |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1320222/full |
| _version_ | 1797347126035873792 |
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| author | Shun Yu Shun Yu Yonghong Zheng Yonghong Zheng Xiaomin Dai Xiaomin Dai Huangjing Chen Huangjing Chen Shengsheng Yang Shengsheng Yang Mingping Ma Mingping Ma Feng Huang Feng Huang Feng Huang Feng Huang Pengli Zhu Pengli Zhu Pengli Zhu Pengli Zhu |
| author_facet | Shun Yu Shun Yu Yonghong Zheng Yonghong Zheng Xiaomin Dai Xiaomin Dai Huangjing Chen Huangjing Chen Shengsheng Yang Shengsheng Yang Mingping Ma Mingping Ma Feng Huang Feng Huang Feng Huang Feng Huang Pengli Zhu Pengli Zhu Pengli Zhu Pengli Zhu |
| author_sort | Shun Yu |
| collection | DOAJ |
| description | BackgroundAlthough atherosclerosis (AS) can affect multiple vascular beds, previous studies have focused on the analysis of single-site AS plaques.ObjectiveThe aim of this study is to explore the differences or similarities in the characteristics of atherosclerotic plaque found in the internal carotid artery, cerebral artery, and coronary artery between patients with atherosclerotic cardiovascular disease (ASCVD) and those without events.MethodsPatients aged ≥ 18 years who underwent both high-resolution vessel wall imaging (HR-VWI) and coronary computed tomography angiography (CCTA) were retrospectively collected and categorized into the ASCVD group and the non-event group. The plaques were then categorized into culprit plaques, non-culprit plaques, and non-event plaques. Plaque morphological data such as stenosis, stenosis grades, plaque length (PL), plaque volume (PV), minimal lumen area (MLA), enhancement grade, and plaque composition data such as calcified plaque volume (CPV), fibrotic plaque volume (FPV), fibro-lipid plaque volume (FLPV), lipid plaque volume (LPV), calcified plaque volume ratio (CPR), fibrotic plaque volume ratio (FPR), fibro-lipid plaque ratio (FLPR), lipid plaque volume ratio (LPR), intraplaque hemorrhage volume (IPHV), and intraplaque hemorrhage volume ratio (IPHR)were recorded and analyzed.ResultsA total of 44 patients (mean age 66 years, SD 9 years, 28 men) were included. In cervicocephalic plaques, the ASCVD group had more severe stenosis grades (p = 0.030) and demonstrated significant differences in LPV, LPR, and CPV (p = 0.044, 0.030, 0.020) compared with the non-event group. In coronary plaques, the ASCVD group had plaques with greater stenosis (p < 0.001), more severe stenosis grades (p < 0.001), larger volumes (p = 0.001), longer length (p = 0.008), larger FLPV (p = 0.012), larger FPV (p = 0.002), and higher FPR (p = 0.043) compared with the non-event group. There were significant differences observed in stenosis (HR-VWI, CCTA: p < 0.001, p < 0.001), stenosis grades (HR-VWI, CCTA: p < 0.001, p < 0.001), plaque length (HR-VWI, CCTA: p = 0.028, p < 0.001), and plaque volume (HR-VWI, CCTA: p = 0.013, p = 0.018) between the non-event plaque, non-culprit plaque, and culprit plaque. In the image analysis of HR-VWI, there were differences observed between IPHR (p < 0.001), LPR (p = 0.001), FPV (p = 0.011), and CPV (p = 0.015) among the three groups of plaques. FLPV and FPV were significantly different among the three different plaque types from the coronary artery (p = 0.043, p = 0.022).ConclusionThere is a consistent pattern of change in plaque characteristics between the cervicocephalic and coronary arteries in the same patient. |
| first_indexed | 2024-03-08T11:43:10Z |
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| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-08T11:43:10Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-12a83cd484fe4b0b9bfdd53db7be97e12024-01-25T04:14:27ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-01-011110.3389/fcvm.2024.13202221320222The value of coordinated analysis of multimodal atherosclerotic plaque imaging in the assessment of cardiovascular and cerebrovascular eventsShun Yu0Shun Yu1Yonghong Zheng2Yonghong Zheng3Xiaomin Dai4Xiaomin Dai5Huangjing Chen6Huangjing Chen7Shengsheng Yang8Shengsheng Yang9Mingping Ma10Mingping Ma11Feng Huang12Feng Huang13Feng Huang14Feng Huang15Pengli Zhu16Pengli Zhu17Pengli Zhu18Pengli Zhu19Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, Republic of ChinaDepartment of Radiology, Fujian Provincial Hospital, Fuzhou, Fujian, Republic of ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, Republic of ChinaDepartment of Radiology, Fujian Provincial Hospital, Fuzhou, Fujian, Republic of ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, Republic of ChinaDepartment of Radiology, Fujian Provincial Hospital, Fuzhou, Fujian, Republic of ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, Republic of ChinaDepartment of Radiology, Fujian Provincial Hospital, Fuzhou, Fujian, Republic of ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, Republic of ChinaDepartment of Radiology, Fujian Provincial Hospital, Fuzhou, Fujian, Republic of ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, Republic of ChinaDepartment of Radiology, Fujian Provincial Hospital, Fuzhou, Fujian, Republic of ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, Republic of ChinaDepartment of Geriatric Medicine, Fujian Provincial Hospital, Fuzhou, Fujian, Republic of ChinaFujian Key Laboratory of Geriatrics, Fuzhou, Fujian, Republic of ChinaFujian Provincial Center for Geriatrics, Fuzhou, Fujian, Republic of ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, Republic of ChinaDepartment of Geriatric Medicine, Fujian Provincial Hospital, Fuzhou, Fujian, Republic of ChinaFujian Key Laboratory of Geriatrics, Fuzhou, Fujian, Republic of ChinaFujian Provincial Center for Geriatrics, Fuzhou, Fujian, Republic of ChinaBackgroundAlthough atherosclerosis (AS) can affect multiple vascular beds, previous studies have focused on the analysis of single-site AS plaques.ObjectiveThe aim of this study is to explore the differences or similarities in the characteristics of atherosclerotic plaque found in the internal carotid artery, cerebral artery, and coronary artery between patients with atherosclerotic cardiovascular disease (ASCVD) and those without events.MethodsPatients aged ≥ 18 years who underwent both high-resolution vessel wall imaging (HR-VWI) and coronary computed tomography angiography (CCTA) were retrospectively collected and categorized into the ASCVD group and the non-event group. The plaques were then categorized into culprit plaques, non-culprit plaques, and non-event plaques. Plaque morphological data such as stenosis, stenosis grades, plaque length (PL), plaque volume (PV), minimal lumen area (MLA), enhancement grade, and plaque composition data such as calcified plaque volume (CPV), fibrotic plaque volume (FPV), fibro-lipid plaque volume (FLPV), lipid plaque volume (LPV), calcified plaque volume ratio (CPR), fibrotic plaque volume ratio (FPR), fibro-lipid plaque ratio (FLPR), lipid plaque volume ratio (LPR), intraplaque hemorrhage volume (IPHV), and intraplaque hemorrhage volume ratio (IPHR)were recorded and analyzed.ResultsA total of 44 patients (mean age 66 years, SD 9 years, 28 men) were included. In cervicocephalic plaques, the ASCVD group had more severe stenosis grades (p = 0.030) and demonstrated significant differences in LPV, LPR, and CPV (p = 0.044, 0.030, 0.020) compared with the non-event group. In coronary plaques, the ASCVD group had plaques with greater stenosis (p < 0.001), more severe stenosis grades (p < 0.001), larger volumes (p = 0.001), longer length (p = 0.008), larger FLPV (p = 0.012), larger FPV (p = 0.002), and higher FPR (p = 0.043) compared with the non-event group. There were significant differences observed in stenosis (HR-VWI, CCTA: p < 0.001, p < 0.001), stenosis grades (HR-VWI, CCTA: p < 0.001, p < 0.001), plaque length (HR-VWI, CCTA: p = 0.028, p < 0.001), and plaque volume (HR-VWI, CCTA: p = 0.013, p = 0.018) between the non-event plaque, non-culprit plaque, and culprit plaque. In the image analysis of HR-VWI, there were differences observed between IPHR (p < 0.001), LPR (p = 0.001), FPV (p = 0.011), and CPV (p = 0.015) among the three groups of plaques. FLPV and FPV were significantly different among the three different plaque types from the coronary artery (p = 0.043, p = 0.022).ConclusionThere is a consistent pattern of change in plaque characteristics between the cervicocephalic and coronary arteries in the same patient.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1320222/fullatherosclerotic cardiovascular disease (ASCVD)high-resolution vessel wall imaging (HR-VWI)coronary computed tomography angiography (CCTA)stroke, coronary heart disease (CHD) |
| spellingShingle | Shun Yu Shun Yu Yonghong Zheng Yonghong Zheng Xiaomin Dai Xiaomin Dai Huangjing Chen Huangjing Chen Shengsheng Yang Shengsheng Yang Mingping Ma Mingping Ma Feng Huang Feng Huang Feng Huang Feng Huang Pengli Zhu Pengli Zhu Pengli Zhu Pengli Zhu The value of coordinated analysis of multimodal atherosclerotic plaque imaging in the assessment of cardiovascular and cerebrovascular events Frontiers in Cardiovascular Medicine atherosclerotic cardiovascular disease (ASCVD) high-resolution vessel wall imaging (HR-VWI) coronary computed tomography angiography (CCTA) stroke, coronary heart disease (CHD) |
| title | The value of coordinated analysis of multimodal atherosclerotic plaque imaging in the assessment of cardiovascular and cerebrovascular events |
| title_full | The value of coordinated analysis of multimodal atherosclerotic plaque imaging in the assessment of cardiovascular and cerebrovascular events |
| title_fullStr | The value of coordinated analysis of multimodal atherosclerotic plaque imaging in the assessment of cardiovascular and cerebrovascular events |
| title_full_unstemmed | The value of coordinated analysis of multimodal atherosclerotic plaque imaging in the assessment of cardiovascular and cerebrovascular events |
| title_short | The value of coordinated analysis of multimodal atherosclerotic plaque imaging in the assessment of cardiovascular and cerebrovascular events |
| title_sort | value of coordinated analysis of multimodal atherosclerotic plaque imaging in the assessment of cardiovascular and cerebrovascular events |
| topic | atherosclerotic cardiovascular disease (ASCVD) high-resolution vessel wall imaging (HR-VWI) coronary computed tomography angiography (CCTA) stroke, coronary heart disease (CHD) |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1320222/full |
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