Scleral Thickness in Steroid-Induced Central Serous Chorioretinopathy
Purpose: To evaluate and compare the scleral thickness of patients with idiopathic central serous chorioretinopathy (iCSC) and steroid-induced central serous chorioretinopathy (sCSC) using anterior-segment OCT. Design: Retrospective, comparative study. Participants: One hundred ten eyes of 110 patie...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Ophthalmology Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666914522000136 |
| _version_ | 1818218833512497152 |
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| author | Shota Sawaguchi, MD Nobuhiro Terao, MD, PhD Naoya Imanaga, MD Sorako Wakugawa, MD Tamaki Tamashiro, MD Yukihide Yamauchi Hideki Koizumi, MD, PhD |
| author_facet | Shota Sawaguchi, MD Nobuhiro Terao, MD, PhD Naoya Imanaga, MD Sorako Wakugawa, MD Tamaki Tamashiro, MD Yukihide Yamauchi Hideki Koizumi, MD, PhD |
| author_sort | Shota Sawaguchi, MD |
| collection | DOAJ |
| description | Purpose: To evaluate and compare the scleral thickness of patients with idiopathic central serous chorioretinopathy (iCSC) and steroid-induced central serous chorioretinopathy (sCSC) using anterior-segment OCT. Design: Retrospective, comparative study. Participants: One hundred ten eyes of 110 patients with central serous chorioretinopathy. Methods: We classified the patients into iCSC and sCSC groups and compared age, sex, spherical equivalent, axial length, subfoveal choroidal thickness (SCT), and scleral thickness. We measured scleral thickness 6 mm posterior to the scleral spur in 4 directions. Main Outcome Measure: Scleral thickness in sCSC eyes. Results: We enrolled 96 and 14 eyes in the iCSC and sCSC groups, respectively. The sCSC group included a greater proportion of women than the iCSC group (42.9% and 13.5%, respectively; P = 0.020). We observed no between-group differences in age, spherical equivalent, axial length, or SCT. Univariate analysis revealed that the sCSC group had a significantly thinner sclera at the superior (423.4 μm vs. 346.6 μm; P < 0.001), temporal (440.1 μm vs. 399.4 μm; P = 0.020), inferior (450.1 μm vs. 395.3 μm; P = 0.001), and nasal (436.6 μm vs. 391.9 μm; P = 0.002) points than the iCSC group. Multivariate analyses revealed that female sex (odds ratio, 4.322; 95% confidence interval, 1.025–18.224; P = 0.046) and mean scleral thickness (odds ratio, 0.972; 95% confidence interval, 0.955–0.990; P = 0.002) were significantly associated with sCSC. Conclusions: The scleral thickness of eyes in the sCSC group was significantly thinner than that in the iCSC group. This suggests that the sclera has less involvement in the pathogenesis of sCSC than in that of iCSC. |
| first_indexed | 2024-12-12T07:30:03Z |
| format | Article |
| id | doaj.art-12a91b5761c24daebcf00d3869a5c855 |
| institution | Directory Open Access Journal |
| issn | 2666-9145 |
| language | English |
| last_indexed | 2024-12-12T07:30:03Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ophthalmology Science |
| spelling | doaj.art-12a91b5761c24daebcf00d3869a5c8552022-12-22T00:33:02ZengElsevierOphthalmology Science2666-91452022-06-0122100124Scleral Thickness in Steroid-Induced Central Serous ChorioretinopathyShota Sawaguchi, MD0Nobuhiro Terao, MD, PhD1Naoya Imanaga, MD2Sorako Wakugawa, MD3Tamaki Tamashiro, MD4Yukihide Yamauchi5Hideki Koizumi, MD, PhD6Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanDepartment of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanDepartment of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanDepartment of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanDepartment of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanDepartment of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanCorrespondence: Hideki Koizumi, MD, PhD, Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Nakagami-gun, Okinawa 903-0215, Japan.; Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanPurpose: To evaluate and compare the scleral thickness of patients with idiopathic central serous chorioretinopathy (iCSC) and steroid-induced central serous chorioretinopathy (sCSC) using anterior-segment OCT. Design: Retrospective, comparative study. Participants: One hundred ten eyes of 110 patients with central serous chorioretinopathy. Methods: We classified the patients into iCSC and sCSC groups and compared age, sex, spherical equivalent, axial length, subfoveal choroidal thickness (SCT), and scleral thickness. We measured scleral thickness 6 mm posterior to the scleral spur in 4 directions. Main Outcome Measure: Scleral thickness in sCSC eyes. Results: We enrolled 96 and 14 eyes in the iCSC and sCSC groups, respectively. The sCSC group included a greater proportion of women than the iCSC group (42.9% and 13.5%, respectively; P = 0.020). We observed no between-group differences in age, spherical equivalent, axial length, or SCT. Univariate analysis revealed that the sCSC group had a significantly thinner sclera at the superior (423.4 μm vs. 346.6 μm; P < 0.001), temporal (440.1 μm vs. 399.4 μm; P = 0.020), inferior (450.1 μm vs. 395.3 μm; P = 0.001), and nasal (436.6 μm vs. 391.9 μm; P = 0.002) points than the iCSC group. Multivariate analyses revealed that female sex (odds ratio, 4.322; 95% confidence interval, 1.025–18.224; P = 0.046) and mean scleral thickness (odds ratio, 0.972; 95% confidence interval, 0.955–0.990; P = 0.002) were significantly associated with sCSC. Conclusions: The scleral thickness of eyes in the sCSC group was significantly thinner than that in the iCSC group. This suggests that the sclera has less involvement in the pathogenesis of sCSC than in that of iCSC.http://www.sciencedirect.com/science/article/pii/S2666914522000136Central serous chorioretinopathyChoroidal thicknessPachychoroidScleral thicknessSteroid |
| spellingShingle | Shota Sawaguchi, MD Nobuhiro Terao, MD, PhD Naoya Imanaga, MD Sorako Wakugawa, MD Tamaki Tamashiro, MD Yukihide Yamauchi Hideki Koizumi, MD, PhD Scleral Thickness in Steroid-Induced Central Serous Chorioretinopathy Ophthalmology Science Central serous chorioretinopathy Choroidal thickness Pachychoroid Scleral thickness Steroid |
| title | Scleral Thickness in Steroid-Induced Central Serous Chorioretinopathy |
| title_full | Scleral Thickness in Steroid-Induced Central Serous Chorioretinopathy |
| title_fullStr | Scleral Thickness in Steroid-Induced Central Serous Chorioretinopathy |
| title_full_unstemmed | Scleral Thickness in Steroid-Induced Central Serous Chorioretinopathy |
| title_short | Scleral Thickness in Steroid-Induced Central Serous Chorioretinopathy |
| title_sort | scleral thickness in steroid induced central serous chorioretinopathy |
| topic | Central serous chorioretinopathy Choroidal thickness Pachychoroid Scleral thickness Steroid |
| url | http://www.sciencedirect.com/science/article/pii/S2666914522000136 |
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