Potential Medical Use of Fullerenols After Two Decades of Oncology Research
Fullerenes are carbon molecules that are found in nature in various forms. They are composed of hexagonal and pentagonal rings that create closed structures. Almost 4 decades ago, fullerenes were identified in the form of C 60 and C 70 , and following the award of the Nobel Prize in Chemistry for th...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-09-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338231201515 |
| _version_ | 1797680672169525248 |
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| author | Rade Injac PhD |
| author_facet | Rade Injac PhD |
| author_sort | Rade Injac PhD |
| collection | DOAJ |
| description | Fullerenes are carbon molecules that are found in nature in various forms. They are composed of hexagonal and pentagonal rings that create closed structures. Almost 4 decades ago, fullerenes were identified in the form of C 60 and C 70 , and following the award of the Nobel Prize in Chemistry for this discovery in 1996, many laboratories started working on their water-soluble derivatives that could be used in different industries, including pharmaceutical industries. One of the first fullerene forms that was the focus of different research groups was fullerenol, C 60 (OH) n ( n = 2-44). Both in-vitro and in-vivo studies have shown that polyhydroxylate fullerene derivatives can potentially be used as either antioxidative agents or cytostatics (depending on their co-administration, forms, and concentration/dose) in biological systems. The current review aimed to present a critical view of the potential applications and limitations of fullerenols in oncology, as understood from the past 2 decades of research. |
| first_indexed | 2024-03-11T23:33:26Z |
| format | Article |
| id | doaj.art-12a983964cef4e07ab87907f9e035446 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-03-11T23:33:26Z |
| publishDate | 2023-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-12a983964cef4e07ab87907f9e0354462023-09-20T06:03:30ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382023-09-012210.1177/15330338231201515Potential Medical Use of Fullerenols After Two Decades of Oncology ResearchRade Injac PhDFullerenes are carbon molecules that are found in nature in various forms. They are composed of hexagonal and pentagonal rings that create closed structures. Almost 4 decades ago, fullerenes were identified in the form of C 60 and C 70 , and following the award of the Nobel Prize in Chemistry for this discovery in 1996, many laboratories started working on their water-soluble derivatives that could be used in different industries, including pharmaceutical industries. One of the first fullerene forms that was the focus of different research groups was fullerenol, C 60 (OH) n ( n = 2-44). Both in-vitro and in-vivo studies have shown that polyhydroxylate fullerene derivatives can potentially be used as either antioxidative agents or cytostatics (depending on their co-administration, forms, and concentration/dose) in biological systems. The current review aimed to present a critical view of the potential applications and limitations of fullerenols in oncology, as understood from the past 2 decades of research.https://doi.org/10.1177/15330338231201515 |
| spellingShingle | Rade Injac PhD Potential Medical Use of Fullerenols After Two Decades of Oncology Research Technology in Cancer Research & Treatment |
| title | Potential Medical Use of Fullerenols After Two Decades of Oncology Research |
| title_full | Potential Medical Use of Fullerenols After Two Decades of Oncology Research |
| title_fullStr | Potential Medical Use of Fullerenols After Two Decades of Oncology Research |
| title_full_unstemmed | Potential Medical Use of Fullerenols After Two Decades of Oncology Research |
| title_short | Potential Medical Use of Fullerenols After Two Decades of Oncology Research |
| title_sort | potential medical use of fullerenols after two decades of oncology research |
| url | https://doi.org/10.1177/15330338231201515 |
| work_keys_str_mv | AT radeinjacphd potentialmedicaluseoffullerenolsaftertwodecadesofoncologyresearch |