The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus
Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-12-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/5/12/3142 |
| _version_ | 1811326500003119104 |
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| author | Abhishek N. Prasad Doug. E. Brackney Gregory D. Ebel |
| author_facet | Abhishek N. Prasad Doug. E. Brackney Gregory D. Ebel |
| author_sort | Abhishek N. Prasad |
| collection | DOAJ |
| description | Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors. |
| first_indexed | 2024-04-13T14:50:21Z |
| format | Article |
| id | doaj.art-12ac068e6eb74ddabb0b661af584a49f |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-13T14:50:21Z |
| publishDate | 2013-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-12ac068e6eb74ddabb0b661af584a49f2022-12-22T02:42:37ZengMDPI AGViruses1999-49152013-12-015123142317010.3390/v5123142v5123142The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile VirusAbhishek N. Prasad0Doug. E. Brackney1Gregory D. Ebel2Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USADepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USADepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USAArthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.http://www.mdpi.com/1999-4915/5/12/3142West Nile virusinnate immunityRNAiTollImdJak/STATautophagyapoptosisarbovirusmosquito |
| spellingShingle | Abhishek N. Prasad Doug. E. Brackney Gregory D. Ebel The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus Viruses West Nile virus innate immunity RNAi Toll Imd Jak/STAT autophagy apoptosis arbovirus mosquito |
| title | The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus |
| title_full | The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus |
| title_fullStr | The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus |
| title_full_unstemmed | The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus |
| title_short | The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus |
| title_sort | role of innate immunity in conditioning mosquito susceptibility to west nile virus |
| topic | West Nile virus innate immunity RNAi Toll Imd Jak/STAT autophagy apoptosis arbovirus mosquito |
| url | http://www.mdpi.com/1999-4915/5/12/3142 |
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