Poxvirus Interactions with the Host Ubiquitin System
The ubiquitin system has emerged as a master regulator of many, if not all, cellular functions. With its large repertoire of conjugating and ligating enzymes, the ubiquitin system holds a unique mechanism to provide selectivity and specificity in manipulating protein function. As intracellular paras...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/10/8/1034 |
| _version_ | 1797522474423812096 |
|---|---|
| author | Sian Lant Carlos Maluquer de Motes |
| author_facet | Sian Lant Carlos Maluquer de Motes |
| author_sort | Sian Lant |
| collection | DOAJ |
| description | The ubiquitin system has emerged as a master regulator of many, if not all, cellular functions. With its large repertoire of conjugating and ligating enzymes, the ubiquitin system holds a unique mechanism to provide selectivity and specificity in manipulating protein function. As intracellular parasites viruses have evolved to modulate the cellular environment to facilitate replication and subvert antiviral responses. Poxviruses are a large family of dsDNA viruses with large coding capacity that is used to synthetise proteins and enzymes needed for replication and morphogenesis as well as suppression of host responses. This review summarises our current knowledge on how poxvirus functions rely on the cellular ubiquitin system, and how poxviruses exploit this system to their own advantage, either facilitating uncoating and genome release and replication or rewiring ubiquitin ligases to downregulate critical antiviral factors. Whilst much remains to be known about the intricate interactions established between poxviruses and the host ubiquitin system, our knowledge has revealed crucial viral processes and important restriction factors that open novel avenues for antiviral treatment and provide fundamental insights on the biology of poxviruses and other virus families. |
| first_indexed | 2024-03-10T08:28:56Z |
| format | Article |
| id | doaj.art-12ad56dc9a7a4e939ea9e1fbf22a369b |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T08:28:56Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-12ad56dc9a7a4e939ea9e1fbf22a369b2023-11-22T09:09:49ZengMDPI AGPathogens2076-08172021-08-01108103410.3390/pathogens10081034Poxvirus Interactions with the Host Ubiquitin SystemSian Lant0Carlos Maluquer de Motes1Department of Microbial Sciences, University of Surrey, Guildford GU2 7XH, UKDepartment of Microbial Sciences, University of Surrey, Guildford GU2 7XH, UKThe ubiquitin system has emerged as a master regulator of many, if not all, cellular functions. With its large repertoire of conjugating and ligating enzymes, the ubiquitin system holds a unique mechanism to provide selectivity and specificity in manipulating protein function. As intracellular parasites viruses have evolved to modulate the cellular environment to facilitate replication and subvert antiviral responses. Poxviruses are a large family of dsDNA viruses with large coding capacity that is used to synthetise proteins and enzymes needed for replication and morphogenesis as well as suppression of host responses. This review summarises our current knowledge on how poxvirus functions rely on the cellular ubiquitin system, and how poxviruses exploit this system to their own advantage, either facilitating uncoating and genome release and replication or rewiring ubiquitin ligases to downregulate critical antiviral factors. Whilst much remains to be known about the intricate interactions established between poxviruses and the host ubiquitin system, our knowledge has revealed crucial viral processes and important restriction factors that open novel avenues for antiviral treatment and provide fundamental insights on the biology of poxviruses and other virus families.https://www.mdpi.com/2076-0817/10/8/1034poxvirusvaccinia virusectromelia virusubiquitin systemE3 ligasesCullin-RING |
| spellingShingle | Sian Lant Carlos Maluquer de Motes Poxvirus Interactions with the Host Ubiquitin System Pathogens poxvirus vaccinia virus ectromelia virus ubiquitin system E3 ligases Cullin-RING |
| title | Poxvirus Interactions with the Host Ubiquitin System |
| title_full | Poxvirus Interactions with the Host Ubiquitin System |
| title_fullStr | Poxvirus Interactions with the Host Ubiquitin System |
| title_full_unstemmed | Poxvirus Interactions with the Host Ubiquitin System |
| title_short | Poxvirus Interactions with the Host Ubiquitin System |
| title_sort | poxvirus interactions with the host ubiquitin system |
| topic | poxvirus vaccinia virus ectromelia virus ubiquitin system E3 ligases Cullin-RING |
| url | https://www.mdpi.com/2076-0817/10/8/1034 |
| work_keys_str_mv | AT sianlant poxvirusinteractionswiththehostubiquitinsystem AT carlosmaluquerdemotes poxvirusinteractionswiththehostubiquitinsystem |