Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes

Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes

The tumor microenvironment (TME) is an important mediator of breast cancer progression. Cancer-associated fibroblasts constitute a major component of the TME and may originate from tissue-associated fibroblasts or infiltrating mesenchymal stromal cells (MSCs). The mechanisms by which cancer cells ac...

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Bibliographic Details
Main Authors: Dylan Dieters-Castator, Paola M. Dantonio, Matt Piaseczny, Guihua Zhang, Jiahui Liu, Miljan Kuljanin, Stephen Sherman, Michael Jewer, Katherine Quesnel, Eun Young Kang, Martin Köbel, Gabrielle M. Siegers, Andrew Leask, David Hess, Gilles Lajoie, Lynne-Marie Postovit
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Breast cancer
NODAL
Proteomics
Secretome
Mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000105

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