Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes
BackgroundThis study was conducted to evaluate possible associations between Dietary Total Antioxidant Capacity (DTAC) and odds of non-alcoholic fatty liver disease (NAFLD) in people with type-2 diabetes mellitus (T2DM).Materials and methodsWe recruited two hundred people with T2DM, and evaluated th...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1037851/full |
| _version_ | 1811331072376438784 |
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| author | Marieh Salavatizadeh Marieh Salavatizadeh Samira Soltanieh Samira Soltanieh Hossein Poustchi Zahra Yari Maryam Shabanpur Asieh Mansour Mohammad E. Khamseh Fariba Alaei-Shahmiri Azita Hekmatdoost |
| author_facet | Marieh Salavatizadeh Marieh Salavatizadeh Samira Soltanieh Samira Soltanieh Hossein Poustchi Zahra Yari Maryam Shabanpur Asieh Mansour Mohammad E. Khamseh Fariba Alaei-Shahmiri Azita Hekmatdoost |
| author_sort | Marieh Salavatizadeh |
| collection | DOAJ |
| description | BackgroundThis study was conducted to evaluate possible associations between Dietary Total Antioxidant Capacity (DTAC) and odds of non-alcoholic fatty liver disease (NAFLD) in people with type-2 diabetes mellitus (T2DM).Materials and methodsWe recruited two hundred people with T2DM, and evaluated their liver steatosis using Fibroscan. Dietary intakes of participants were assessed using a validated food frequency questionnaire. DTAC was computed via ferric reducing antioxidant power (FRAP).ResultsIn the crude model, no statistically significant association was found between DTAC and the odds of NAFLD in people with diabetes. However, after adjustment for potential confounders including age, gender, diabetes duration, smoking status, physical activity, BMI, waist circumference, and energy, the most reduced adjusted OR was indicated for the third tertile vs. the first one (OR: 0.28, 95% CI: 0.09–0.81, P = 0.02), meaning that diabetic patients in the third tertile of DTAC had 72% decreased risk of NAFLD in comparison to those in the first one. The relationship was remained significant after additional adjustment for HOMA-IR, HbA1c, serum Triglyceride (TG), and low-density lipoprotein-cholesterol (LDL) levels (OR: 0.29, 95% CI: 0.09–0.93, P = 0.03). Importantly, a dose-response pattern was demonstrated for DTAC and risk of NAFLD (P = 0.04).ConclusionHigher DTAC was related with a decreased risk of NAFLD in individuals with diabetes. |
| first_indexed | 2024-04-13T16:13:24Z |
| format | Article |
| id | doaj.art-12afcdf41d034288bfaff69a6813e635 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-13T16:13:24Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-12afcdf41d034288bfaff69a6813e6352022-12-22T02:40:08ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-11-01910.3389/fnut.2022.10378511037851Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetesMarieh Salavatizadeh0Marieh Salavatizadeh1Samira Soltanieh2Samira Soltanieh3Hossein Poustchi4Zahra Yari5Maryam Shabanpur6Asieh Mansour7Mohammad E. Khamseh8Fariba Alaei-Shahmiri9Azita Hekmatdoost10Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IranEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, IranDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IranEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, IranLiver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Nutrition Research, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Nutrition, Jahrom University of Medical Sciences, Jahrom, IranEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, IranEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, IranDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IranBackgroundThis study was conducted to evaluate possible associations between Dietary Total Antioxidant Capacity (DTAC) and odds of non-alcoholic fatty liver disease (NAFLD) in people with type-2 diabetes mellitus (T2DM).Materials and methodsWe recruited two hundred people with T2DM, and evaluated their liver steatosis using Fibroscan. Dietary intakes of participants were assessed using a validated food frequency questionnaire. DTAC was computed via ferric reducing antioxidant power (FRAP).ResultsIn the crude model, no statistically significant association was found between DTAC and the odds of NAFLD in people with diabetes. However, after adjustment for potential confounders including age, gender, diabetes duration, smoking status, physical activity, BMI, waist circumference, and energy, the most reduced adjusted OR was indicated for the third tertile vs. the first one (OR: 0.28, 95% CI: 0.09–0.81, P = 0.02), meaning that diabetic patients in the third tertile of DTAC had 72% decreased risk of NAFLD in comparison to those in the first one. The relationship was remained significant after additional adjustment for HOMA-IR, HbA1c, serum Triglyceride (TG), and low-density lipoprotein-cholesterol (LDL) levels (OR: 0.29, 95% CI: 0.09–0.93, P = 0.03). Importantly, a dose-response pattern was demonstrated for DTAC and risk of NAFLD (P = 0.04).ConclusionHigher DTAC was related with a decreased risk of NAFLD in individuals with diabetes.https://www.frontiersin.org/articles/10.3389/fnut.2022.1037851/fullNAFLDdiabetesdietDTACantioxidant |
| spellingShingle | Marieh Salavatizadeh Marieh Salavatizadeh Samira Soltanieh Samira Soltanieh Hossein Poustchi Zahra Yari Maryam Shabanpur Asieh Mansour Mohammad E. Khamseh Fariba Alaei-Shahmiri Azita Hekmatdoost Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes Frontiers in Nutrition NAFLD diabetes diet DTAC antioxidant |
| title | Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes |
| title_full | Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes |
| title_fullStr | Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes |
| title_full_unstemmed | Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes |
| title_short | Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes |
| title_sort | dietary total antioxidant capacity is inversely associated with the odds of non alcoholic fatty liver disease in people with type 2 diabetes |
| topic | NAFLD diabetes diet DTAC antioxidant |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1037851/full |
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