Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders
Chronic inflammation may not begin with local tissue disorders, such as hypoxia, but with the accumulation of critically activated macrophages in one site. The purpose of this review is to analyze the data reported in the scientific literature on the features of the functions of macrophages and thei...
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MDPI AG
2020-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/10/400 |
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| author | Daria Skuratovskaia Maria Vulf Olga Khaziakhmatova Vladimir Malashchenko Aleksandra Komar Egor Shunkin Valeriya Shupletsova Andrei Goncharov Olga Urazova Larisa Litvinova |
| author_facet | Daria Skuratovskaia Maria Vulf Olga Khaziakhmatova Vladimir Malashchenko Aleksandra Komar Egor Shunkin Valeriya Shupletsova Andrei Goncharov Olga Urazova Larisa Litvinova |
| author_sort | Daria Skuratovskaia |
| collection | DOAJ |
| description | Chronic inflammation may not begin with local tissue disorders, such as hypoxia, but with the accumulation of critically activated macrophages in one site. The purpose of this review is to analyze the data reported in the scientific literature on the features of the functions of macrophages and their contributions to the development of pathology in various tissues during aseptic inflammation in obese subjects. In individuals with obesity, increased migration of monocytes from the peripheral blood to various tissues, the proliferation of resident macrophages and a change in the balance between alternatively activated anti-inflammatory macrophages (M2) and pro-inflammatory classically activated macrophages (M1) towards the latter have been observed. The primary cause of some metabolic pathologies has been precisely identified as the recruitment of macrophages with an altered phenotype, which is probably typical for many other pathologies. Recent studies have identified phenotypes, such as metabolically activated M (MMe), oxidized (Mox), hemoglobin-related macrophages (Mhem and MHb), M4 and neuroimmunological macrophages (NAM, SAM), which directly and indirectly affect energy metabolism. The high heterogeneity of macrophages in tissues contributes to the involvement of these cells in the development of a wide range of immune responses, including pathological ones. The replenishment of tissue-specific macrophages occurs at the expense of infiltrating monocyte-derived macrophages (MoMFs) in the pathological process. The origin of MoMFs from a general precursor retains their common regulatory mechanisms and similar sensitivity to regulatory stimuli. This makes it possible to find universal approaches to the effect on these cells and, as a consequence, universal approaches for the treatment of various pathological conditions. |
| first_indexed | 2024-03-10T15:46:25Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T15:46:25Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-12b133f8884f4c18ac10d89559a27cd42023-11-20T16:25:06ZengMDPI AGBiomedicines2227-90592020-10-0181040010.3390/biomedicines8100400Tissue-Specific Role of Macrophages in Noninfectious Inflammatory DisordersDaria Skuratovskaia0Maria Vulf1Olga Khaziakhmatova2Vladimir Malashchenko3Aleksandra Komar4Egor Shunkin5Valeriya Shupletsova6Andrei Goncharov7Olga Urazova8Larisa Litvinova9Center for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaPathophysiology Division, Siberian State Medical University, 634050 Tomsk, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaChronic inflammation may not begin with local tissue disorders, such as hypoxia, but with the accumulation of critically activated macrophages in one site. The purpose of this review is to analyze the data reported in the scientific literature on the features of the functions of macrophages and their contributions to the development of pathology in various tissues during aseptic inflammation in obese subjects. In individuals with obesity, increased migration of monocytes from the peripheral blood to various tissues, the proliferation of resident macrophages and a change in the balance between alternatively activated anti-inflammatory macrophages (M2) and pro-inflammatory classically activated macrophages (M1) towards the latter have been observed. The primary cause of some metabolic pathologies has been precisely identified as the recruitment of macrophages with an altered phenotype, which is probably typical for many other pathologies. Recent studies have identified phenotypes, such as metabolically activated M (MMe), oxidized (Mox), hemoglobin-related macrophages (Mhem and MHb), M4 and neuroimmunological macrophages (NAM, SAM), which directly and indirectly affect energy metabolism. The high heterogeneity of macrophages in tissues contributes to the involvement of these cells in the development of a wide range of immune responses, including pathological ones. The replenishment of tissue-specific macrophages occurs at the expense of infiltrating monocyte-derived macrophages (MoMFs) in the pathological process. The origin of MoMFs from a general precursor retains their common regulatory mechanisms and similar sensitivity to regulatory stimuli. This makes it possible to find universal approaches to the effect on these cells and, as a consequence, universal approaches for the treatment of various pathological conditions.https://www.mdpi.com/2227-9059/8/10/400obesityinflammationmacrophageadipose tissueliverNAFLD |
| spellingShingle | Daria Skuratovskaia Maria Vulf Olga Khaziakhmatova Vladimir Malashchenko Aleksandra Komar Egor Shunkin Valeriya Shupletsova Andrei Goncharov Olga Urazova Larisa Litvinova Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders Biomedicines obesity inflammation macrophage adipose tissue liver NAFLD |
| title | Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders |
| title_full | Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders |
| title_fullStr | Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders |
| title_full_unstemmed | Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders |
| title_short | Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders |
| title_sort | tissue specific role of macrophages in noninfectious inflammatory disorders |
| topic | obesity inflammation macrophage adipose tissue liver NAFLD |
| url | https://www.mdpi.com/2227-9059/8/10/400 |
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