TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state

Summary: Mouse embryonic stem cells (mESCs) can be maintained in vitro in defined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory factor (LIF), which act synergistically to promote self-renewal and pluripotency. Here, we find that gen...

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Bibliographic Details
Main Authors: Nikolaos Doumpas, Simon Söderholm, Smarth Narula, Steven Moreira, Bradley W. Doble, Claudio Cantù, Konrad Basler
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
Wnt signaling
β-catenin
mESC
pluripotency
TCF/LEF
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011529

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