Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

Affinity and dose of T cell receptor (TCR) interaction with antigens govern the magnitude of CD4+ T cell responses, but questions remain regarding the quantitative translation of TCR engagement into downstream signals. We find that while the response of mouse CD4+ T cells to antigenic stimulation is...

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Detalhes bibliográficos
Main Authors: Karmel A Allison, Eniko Sajti, Jana G Collier, David Gosselin, Ty Dale Troutman, Erica L Stone, Stephen M Hedrick, Christopher K Glass
Formato: Artigo
Idioma:English
Publicado em: eLife Sciences Publications Ltd 2016-07-01
Colecção:eLife
Assuntos:
transcription factors
enhancers
protein kinase
Acesso em linha:https://elifesciences.org/articles/10134

Internet

https://elifesciences.org/articles/10134

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