Effects of Ingesting Food Containing Heat-Killed <i>Lactococcus lactis</i> Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study
<i>Lactococcus lactis</i> strain Plasma (LC-Plasma) is a unique lactic acid bacterium that activates plasmacytoid dendritic cells (pDCs). We evaluated the effect of LC-Plasma on fatigue indices and dendritic cells activity in athletes after 14 days’ continuous exercise load. Thirty-seven...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/7/1754 |
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| author | Yuta Komano Kosuke Fukao Kazunori Shimada Hisashi Naito Yoshihiko Ishihara Toshio Fujii Takeshi Kokubo Hiroyuki Daida |
| author_facet | Yuta Komano Kosuke Fukao Kazunori Shimada Hisashi Naito Yoshihiko Ishihara Toshio Fujii Takeshi Kokubo Hiroyuki Daida |
| author_sort | Yuta Komano |
| collection | DOAJ |
| description | <i>Lactococcus lactis</i> strain Plasma (LC-Plasma) is a unique lactic acid bacterium that activates plasmacytoid dendritic cells (pDCs). We evaluated the effect of LC-Plasma on fatigue indices and dendritic cells activity in athletes after 14 days’ continuous exercise load. Thirty-seven participants were divided into two groups and consumed placebo (PL) or LC-Plasma capsules (containing 100 billion cells) daily for 14 days. Maturation markers on dendritic cells, blood parameters, physiological indices, and fatigue-related indices were recorded on days 1 and 15 (before and after exercise). Cumulative days of symptoms relating to physical conditions were also recorded during the continuous exercise period. We observed that CD86 as a maturation marker on pDCs was significantly higher and that cumulative days of fatigue were significantly fewer in the LC-Plasma group than in the Placebo group on day 15. We also conducted 2 h ergometer exercise on day 15 to evaluate fatigue. The results showed that autonomic fatigue parameters (LF/HF) were significantly lower in the LC-Plasma group. These results suggest that LC-Plasma supplementation alleviates fatigue accumulation and increases pDC activity caused by a continuous high training load. |
| first_indexed | 2024-03-11T05:27:24Z |
| format | Article |
| id | doaj.art-12b31607998d4f828d25c175bef19113 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T05:27:24Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-12b31607998d4f828d25c175bef191132023-11-17T17:21:35ZengMDPI AGNutrients2072-66432023-04-01157175410.3390/nu15071754Effects of Ingesting Food Containing Heat-Killed <i>Lactococcus lactis</i> Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group StudyYuta Komano0Kosuke Fukao1Kazunori Shimada2Hisashi Naito3Yoshihiko Ishihara4Toshio Fujii5Takeshi Kokubo6Hiroyuki Daida7Kirin Holdings Company, Limited, Tokyo 164-0001, JapanGraduate School of Health and Sports Science, Juntendo University, Chiba 270-1695, JapanGraduate School of Health and Sports Science, Juntendo University, Chiba 270-1695, JapanGraduate School of Health and Sports Science, Juntendo University, Chiba 270-1695, JapanSchool of Science and Technology for Future Life, Department of Humanities and Social Sciences, Tokyo Denki University, Tokyo 120-8551, JapanKirin Holdings Company, Limited, Tokyo 164-0001, JapanKirin Holdings Company, Limited, Tokyo 164-0001, JapanFaculty of Health Science, Juntendo University, Tokyo 113-8421, Japan<i>Lactococcus lactis</i> strain Plasma (LC-Plasma) is a unique lactic acid bacterium that activates plasmacytoid dendritic cells (pDCs). We evaluated the effect of LC-Plasma on fatigue indices and dendritic cells activity in athletes after 14 days’ continuous exercise load. Thirty-seven participants were divided into two groups and consumed placebo (PL) or LC-Plasma capsules (containing 100 billion cells) daily for 14 days. Maturation markers on dendritic cells, blood parameters, physiological indices, and fatigue-related indices were recorded on days 1 and 15 (before and after exercise). Cumulative days of symptoms relating to physical conditions were also recorded during the continuous exercise period. We observed that CD86 as a maturation marker on pDCs was significantly higher and that cumulative days of fatigue were significantly fewer in the LC-Plasma group than in the Placebo group on day 15. We also conducted 2 h ergometer exercise on day 15 to evaluate fatigue. The results showed that autonomic fatigue parameters (LF/HF) were significantly lower in the LC-Plasma group. These results suggest that LC-Plasma supplementation alleviates fatigue accumulation and increases pDC activity caused by a continuous high training load.https://www.mdpi.com/2072-6643/15/7/1754<i>Lactococcus lactis</i> strain Plasmafatiguedendritic cellhigh training load |
| spellingShingle | Yuta Komano Kosuke Fukao Kazunori Shimada Hisashi Naito Yoshihiko Ishihara Toshio Fujii Takeshi Kokubo Hiroyuki Daida Effects of Ingesting Food Containing Heat-Killed <i>Lactococcus lactis</i> Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study Nutrients <i>Lactococcus lactis</i> strain Plasma fatigue dendritic cell high training load |
| title | Effects of Ingesting Food Containing Heat-Killed <i>Lactococcus lactis</i> Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study |
| title_full | Effects of Ingesting Food Containing Heat-Killed <i>Lactococcus lactis</i> Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study |
| title_fullStr | Effects of Ingesting Food Containing Heat-Killed <i>Lactococcus lactis</i> Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study |
| title_full_unstemmed | Effects of Ingesting Food Containing Heat-Killed <i>Lactococcus lactis</i> Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study |
| title_short | Effects of Ingesting Food Containing Heat-Killed <i>Lactococcus lactis</i> Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study |
| title_sort | effects of ingesting food containing heat killed i lactococcus lactis i strain plasma on fatigue and immune related indices after high training load a randomized double blind placebo controlled and parallel group study |
| topic | <i>Lactococcus lactis</i> strain Plasma fatigue dendritic cell high training load |
| url | https://www.mdpi.com/2072-6643/15/7/1754 |
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