Numerical simulation of chemical separations using multimodal adsorption isotherms
High demand for next-generation biotherapeutics requires the development of novel adsorptive chromatography media to ensure high-volume throughput of purified product. These media use multiple modes of interaction with the product to recover it selectively from impurities in the solution, leading to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Results in Applied Mathematics |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590037420300327 |
| _version_ | 1818995411649560576 |
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| author | A.B. Wilson E.W. Jenkins J. Wang S.M. Husson |
| author_facet | A.B. Wilson E.W. Jenkins J. Wang S.M. Husson |
| author_sort | A.B. Wilson |
| collection | DOAJ |
| description | High demand for next-generation biotherapeutics requires the development of novel adsorptive chromatography media to ensure high-volume throughput of purified product. These media use multiple modes of interaction with the product to recover it selectively from impurities in the solution, leading to mathematically complex models to describe the adsorption process. This work describes a simulation environment designed to handle the new isotherm relationships. The main advantage of the simulation algorithm is it allows isotherm models in which the solid phase concentration is defined implicitly in terms of the liquid phase concentration. Numerical results indicate optimal convergence of the method and show the effectiveness of the framework in matching experimental data. Simulations using both instantaneous and non-instantaneous adsorption model equations are provided. |
| first_indexed | 2024-12-20T21:13:25Z |
| format | Article |
| id | doaj.art-12b3429f5bf443d9b17cab38d8277110 |
| institution | Directory Open Access Journal |
| issn | 2590-0374 |
| language | English |
| last_indexed | 2024-12-20T21:13:25Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Applied Mathematics |
| spelling | doaj.art-12b3429f5bf443d9b17cab38d82771102022-12-21T19:26:28ZengElsevierResults in Applied Mathematics2590-03742020-08-017100122Numerical simulation of chemical separations using multimodal adsorption isothermsA.B. Wilson0E.W. Jenkins1J. Wang2S.M. Husson3Department of Mathematics, Augusta University, Allgood Hall N-322, 1120 15th Street, Augusta, GA 30912, USA; Corresponding author.School of Mathematical and Statistical Sciences, Clemson University, Clemson, SC 29634, USADepartment of Chemical and Biomolecular Engineering, Center for Advanced Engineering Fibers and Films, Clemson University, 127 Earle Hall, Clemson, SC 29634, USADepartment of Chemical and Biomolecular Engineering, Center for Advanced Engineering Fibers and Films, Clemson University, 127 Earle Hall, Clemson, SC 29634, USAHigh demand for next-generation biotherapeutics requires the development of novel adsorptive chromatography media to ensure high-volume throughput of purified product. These media use multiple modes of interaction with the product to recover it selectively from impurities in the solution, leading to mathematically complex models to describe the adsorption process. This work describes a simulation environment designed to handle the new isotherm relationships. The main advantage of the simulation algorithm is it allows isotherm models in which the solid phase concentration is defined implicitly in terms of the liquid phase concentration. Numerical results indicate optimal convergence of the method and show the effectiveness of the framework in matching experimental data. Simulations using both instantaneous and non-instantaneous adsorption model equations are provided.http://www.sciencedirect.com/science/article/pii/S2590037420300327 |
| spellingShingle | A.B. Wilson E.W. Jenkins J. Wang S.M. Husson Numerical simulation of chemical separations using multimodal adsorption isotherms Results in Applied Mathematics |
| title | Numerical simulation of chemical separations using multimodal adsorption isotherms |
| title_full | Numerical simulation of chemical separations using multimodal adsorption isotherms |
| title_fullStr | Numerical simulation of chemical separations using multimodal adsorption isotherms |
| title_full_unstemmed | Numerical simulation of chemical separations using multimodal adsorption isotherms |
| title_short | Numerical simulation of chemical separations using multimodal adsorption isotherms |
| title_sort | numerical simulation of chemical separations using multimodal adsorption isotherms |
| url | http://www.sciencedirect.com/science/article/pii/S2590037420300327 |
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