Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration
Hepatocellular carcinoma (HCC) is a development of severe liver disease frequently due to HBV and/or HCV infection. The aim of this retrospective study was to evaluate the development of HCC in patients with HBV-HCV chronic infection compared with patients with single HBV or HCV infection and the vi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119308038 |
| _version_ | 1819012230318915584 |
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| author | Rosa Zampino, M.D. Ph.D. Maria A. Pisaturo Grazia Cirillo Aldo Marrone Margherita Macera Luca Rinaldi Maria Stanzione Emanuele Durante-Mangoni Ivan Gentile Evangelista Sagnelli Giuseppe Signoriello Emanuele Miraglia del Giudice Luigi E. Adinolfi Nicola Coppola |
| author_facet | Rosa Zampino, M.D. Ph.D. Maria A. Pisaturo Grazia Cirillo Aldo Marrone Margherita Macera Luca Rinaldi Maria Stanzione Emanuele Durante-Mangoni Ivan Gentile Evangelista Sagnelli Giuseppe Signoriello Emanuele Miraglia del Giudice Luigi E. Adinolfi Nicola Coppola |
| author_sort | Rosa Zampino, M.D. Ph.D. |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a development of severe liver disease frequently due to HBV and/or HCV infection. The aim of this retrospective study was to evaluate the development of HCC in patients with HBV-HCV chronic infection compared with patients with single HBV or HCV infection and the viral and host factors correlated to HCC in co-infected patients. We studied 268 patients with histology proven chronic hepatitis: 56 had HBV-HCV co-infection (HBV-HCV group), 46 had HBV infection (HBV group) and 166 had HCV infection (HCV group). Patients were followed up for at least 3 years. Viral and host factors were studied. HCC was more frequent in HBV-HCV group (14%) compared with HBV (2%, p = 0.006) and HCV monoinfected (4%, p = 0.006). The Mantel-Haenszel test used to investigate the relationship between HBV-HCV co-infection and development of HCC indicated an association between development of HCC and HBV-HCV co-infection (p < 0.001). In the HBV-HCV group, patients with HCC were significantly older (p = 0.000), had longer disease duration (p = 0.001), higher blood glucose levels (p = 0.001), lower levels of steatosis (p = 0.02), higher levels of fibrosis (p = 0.000), higher HCV RNA (p = 0.01) than those without HCC. ALT, lipid profile, PNPLA3 variant distribution and HBV viral load did not differ among co-infected patients with or without HCC. In conclusion HCC was more frequent in our patients with HBV-HCV co-infection, than in those with HBV or HCV mono-infection; possible associated risk factors for HCC development seem a long duration of disease, high levels of fibrosis and carbohydrate intolerance. |
| first_indexed | 2024-12-21T01:40:45Z |
| format | Article |
| id | doaj.art-12b54a191c464990b978a9c736e0832c |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-21T01:40:45Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-12b54a191c464990b978a9c736e0832c2022-12-21T19:20:10ZengElsevierAnnals of Hepatology1665-26812015-01-011417582Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease durationRosa Zampino, M.D. Ph.D.0Maria A. Pisaturo1Grazia Cirillo2Aldo Marrone3Margherita Macera4Luca Rinaldi5Maria Stanzione6Emanuele Durante-Mangoni7Ivan Gentile8Evangelista Sagnelli9Giuseppe Signoriello10Emanuele Miraglia del Giudice11Luigi E. Adinolfi12Nicola Coppola13Internal Medicine and Hepatology, Italy; Correspondence and reprint request:Department of Mental Health and Public Medicine, Section of Infectious Diseases, ItalyDepartment of Pediatrics, ItalyInternal Medicine and Hepatology, ItalyDepartment of Clinical and Experimental Medicine and Surgery F. Magrassi e A. Lanzara, ItalyInternal Medicine and Hepatology, ItalyDepartment of Clinical and Experimental Medicine and Surgery F. Magrassi e A. Lanzara, ItalyInternal Medicine Monaldi Hospital, ItalySecond University of Naples; Department of Clinical Medicine and Surgery-University of Naples Federico, ItalyDepartment of Mental Health and Public Medicine, Section of Infectious Diseases, ItalyDepartment of Mental Health and Public Medicine, Section of Infectious Diseases, ItalyDepartment of Pediatrics, ItalyInternal Medicine and Hepatology, ItalyDepartment of Mental Health and Public Medicine, Section of Infectious Diseases, ItalyHepatocellular carcinoma (HCC) is a development of severe liver disease frequently due to HBV and/or HCV infection. The aim of this retrospective study was to evaluate the development of HCC in patients with HBV-HCV chronic infection compared with patients with single HBV or HCV infection and the viral and host factors correlated to HCC in co-infected patients. We studied 268 patients with histology proven chronic hepatitis: 56 had HBV-HCV co-infection (HBV-HCV group), 46 had HBV infection (HBV group) and 166 had HCV infection (HCV group). Patients were followed up for at least 3 years. Viral and host factors were studied. HCC was more frequent in HBV-HCV group (14%) compared with HBV (2%, p = 0.006) and HCV monoinfected (4%, p = 0.006). The Mantel-Haenszel test used to investigate the relationship between HBV-HCV co-infection and development of HCC indicated an association between development of HCC and HBV-HCV co-infection (p < 0.001). In the HBV-HCV group, patients with HCC were significantly older (p = 0.000), had longer disease duration (p = 0.001), higher blood glucose levels (p = 0.001), lower levels of steatosis (p = 0.02), higher levels of fibrosis (p = 0.000), higher HCV RNA (p = 0.01) than those without HCC. ALT, lipid profile, PNPLA3 variant distribution and HBV viral load did not differ among co-infected patients with or without HCC. In conclusion HCC was more frequent in our patients with HBV-HCV co-infection, than in those with HBV or HCV mono-infection; possible associated risk factors for HCC development seem a long duration of disease, high levels of fibrosis and carbohydrate intolerance.http://www.sciencedirect.com/science/article/pii/S1665268119308038HCCRisk factorsChronic hepatitis |
| spellingShingle | Rosa Zampino, M.D. Ph.D. Maria A. Pisaturo Grazia Cirillo Aldo Marrone Margherita Macera Luca Rinaldi Maria Stanzione Emanuele Durante-Mangoni Ivan Gentile Evangelista Sagnelli Giuseppe Signoriello Emanuele Miraglia del Giudice Luigi E. Adinolfi Nicola Coppola Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration Annals of Hepatology HCC Risk factors Chronic hepatitis |
| title | Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration |
| title_full | Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration |
| title_fullStr | Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration |
| title_full_unstemmed | Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration |
| title_short | Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration |
| title_sort | hepatocellular carcinoma in chronic hbv hcv co infection is correlated to fibrosis and disease duration |
| topic | HCC Risk factors Chronic hepatitis |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119308038 |
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