Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis
Cholesterol has been reported to be accumulated in cancer cells. The metabolic dysregulation of the cholesterol is associated with tumor development and progression. The cholesterol-lowering drugs have been found to be involved in the prevention and treatment of various cancers. Akt, a serine/threon...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.724149/full |
| _version_ | 1818597139551354880 |
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| author | Navneet Kumar Chandi C. Mandal |
| author_facet | Navneet Kumar Chandi C. Mandal |
| author_sort | Navneet Kumar |
| collection | DOAJ |
| description | Cholesterol has been reported to be accumulated in cancer cells. The metabolic dysregulation of the cholesterol is associated with tumor development and progression. The cholesterol-lowering drugs have been found to be involved in the prevention and treatment of various cancers. Akt, a serine/threonine kinase, can modulate the role of several downstream proteins involved in cell proliferation, migration, invasion, metabolism, and apoptosis. Since its involvement in several signaling pathways, its dysregulation is commonly reported in several cancers. Thus, targeting Akt could be an effective approach for cancer prevention and therapy. Cholesterol-lowering drugs have been found to affect the expression of Akt, and its activation in the cancer cells and thus have shown anticancer activity in different type of cancers. These drugs act on various signaling pathways such as PTEN/Akt, PI3k/Akt, Akt/NF-κB, Akt/FOXO1, Akt/mTOR, etc., which will be discussed in this article. This review article will discuss the significance of cholesterol in cancer cells, cholesterol-lowering drugs, the role of Akt in cancer cells, and the effects of cholesterol-lowering drugs on Akt in the prevention of therapy resistance and metastasis. |
| first_indexed | 2024-12-16T11:43:03Z |
| format | Article |
| id | doaj.art-12b581347adb4a749f18228915191807 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-16T11:43:03Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-12b581347adb4a749f182289151918072022-12-21T22:32:53ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-09-011210.3389/fgene.2021.724149724149Cholesterol-Lowering Drugs on Akt Signaling for Prevention of TumorigenesisNavneet Kumar0Chandi C. Mandal1Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, IndiaDepartment of Biochemistry, School of Life Sciences, Central University of Rajasthan, Ajmer, IndiaCholesterol has been reported to be accumulated in cancer cells. The metabolic dysregulation of the cholesterol is associated with tumor development and progression. The cholesterol-lowering drugs have been found to be involved in the prevention and treatment of various cancers. Akt, a serine/threonine kinase, can modulate the role of several downstream proteins involved in cell proliferation, migration, invasion, metabolism, and apoptosis. Since its involvement in several signaling pathways, its dysregulation is commonly reported in several cancers. Thus, targeting Akt could be an effective approach for cancer prevention and therapy. Cholesterol-lowering drugs have been found to affect the expression of Akt, and its activation in the cancer cells and thus have shown anticancer activity in different type of cancers. These drugs act on various signaling pathways such as PTEN/Akt, PI3k/Akt, Akt/NF-κB, Akt/FOXO1, Akt/mTOR, etc., which will be discussed in this article. This review article will discuss the significance of cholesterol in cancer cells, cholesterol-lowering drugs, the role of Akt in cancer cells, and the effects of cholesterol-lowering drugs on Akt in the prevention of therapy resistance and metastasis.https://www.frontiersin.org/articles/10.3389/fgene.2021.724149/fullcholesterolcholesterol-lowering drugsAkt signalingcancerstatinsfenofibrate |
| spellingShingle | Navneet Kumar Chandi C. Mandal Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis Frontiers in Genetics cholesterol cholesterol-lowering drugs Akt signaling cancer statins fenofibrate |
| title | Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis |
| title_full | Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis |
| title_fullStr | Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis |
| title_full_unstemmed | Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis |
| title_short | Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis |
| title_sort | cholesterol lowering drugs on akt signaling for prevention of tumorigenesis |
| topic | cholesterol cholesterol-lowering drugs Akt signaling cancer statins fenofibrate |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.724149/full |
| work_keys_str_mv | AT navneetkumar cholesterolloweringdrugsonaktsignalingforpreventionoftumorigenesis AT chandicmandal cholesterolloweringdrugsonaktsignalingforpreventionoftumorigenesis |