ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein

ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein

Mutations in <i>ATP13A2</i> (<i>PARK9</i>), an autophagy-related protein, cause Kufor–Rakeb syndrome, an autosomal recessive, juvenile-onset form of parkinsonism. α-Synuclein (α-syn) is a presynaptic neuronal protein that forms toxic aggregates in Parkinson’s disease (PD). We...

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Bibliographic Details
Main Authors: Nisha R. Dhanushkodi, Salema B. Abul Khair, Mustafa T. Ardah, M. Emdadul Haque
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein
ATP13A2
autophagy
Drosophila
parkinsonism
sleep
Online Access:https://www.mdpi.com/1422-0067/24/2/1775

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