Induction of Cardiac Pathology: Endogenous versus Exogenous Nrf2 Upregulation

Induction of Cardiac Pathology: Endogenous versus Exogenous Nrf2 Upregulation

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of the endogenous antioxidant response to reactive oxygen species as well as a controller of Phase II detoxification in response to xenobiotics. This amenity to specific external manipulation exploits the binding affinity of Nr...

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Bibliographic Details
Main Authors: Bryan J. Mathis, Hideyuki Kato, Yuji Hiramatsu
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
Nrf2
Keap1
cardiomyopathy
bardoloxone
Reata
CDDO
Online Access:https://www.mdpi.com/2073-4409/11/23/3855

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