Associations of Tumor Necrosis Factor-Alpha Gene Polymorphisms <i>(TNF)-α</i> TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-Alpha Serum Concentration with Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a neurodegenerative disease leading to irreversible central vision loss among the elderly in developed countries. While the disease accounts for 9% of all cases of vision loss, the prevalence of AMD is likely to increase due to the exponential aging of the p...
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MDPI AG
2022-06-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/7/928 |
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| author | Guoda Zazeckyte Greta Gedvilaite Alvita Vilkeviciute Loresa Kriauciuniene Vilma Jurate Balciuniene Ruta Mockute Rasa Liutkeviciene |
| author_facet | Guoda Zazeckyte Greta Gedvilaite Alvita Vilkeviciute Loresa Kriauciuniene Vilma Jurate Balciuniene Ruta Mockute Rasa Liutkeviciene |
| author_sort | Guoda Zazeckyte |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) is a neurodegenerative disease leading to irreversible central vision loss among the elderly in developed countries. While the disease accounts for 9% of all cases of vision loss, the prevalence of AMD is likely to increase due to the exponential aging of the population. Due to this reason, our study aimed to determine the associations of tumor necrosis factor-alpha (<i>TNF-α</i>) gene single-nucleotide polymorphisms (SNPs) TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-α serum concentration with age-related macular degeneration. Analysis of <i>TNF-α</i> rs1800630, rs1800629, and rs361525 polymorphisms showed that the <i>TNF-α</i> rs1800630 A allele was statistically significantly more frequent in the exudative AMD group compared to the control group (<i>p</i> = 0.029). Additionally, the <i>TNF-α</i> rs1800630 A allele was more frequent in females with exudative AMD than in the control group of healthy females (<i>p</i> = 0.027). The <i>TNF-α</i> rs1800630 A allele was more frequent in females with exudative AMD than in females with early AMD (<i>p</i> = 0.014). <i>TNF-α</i> rs1800630, rs1800629, and rs361525 haplotype A-A-G were associated with decreased odds of exudative AMD (<i>p</i> < 0.0001), and haplotype A-G-G was associated with 24-fold increased exudative AMD occurrence (<i>p</i> < 0.0001). TNF-α protein levels were lower in subjects with exudative AMD compared to the control group (<i>p</i> < 0.001). The study showed significant associations between inflammatory cytokine <i>TNF-α</i> single-nucleotide polymorphisms and serum level with AMD pathogenesis. Analysis of <i>TNF-α</i> genotypes and serum concentration may be helpful for the AMD diagnosis. |
| first_indexed | 2024-03-09T13:30:50Z |
| format | Article |
| id | doaj.art-12baff6137db498c94d997856e766b8a |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T13:30:50Z |
| publishDate | 2022-06-01 |
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| series | Life |
| spelling | doaj.art-12baff6137db498c94d997856e766b8a2023-11-30T21:17:25ZengMDPI AGLife2075-17292022-06-0112792810.3390/life12070928Associations of Tumor Necrosis Factor-Alpha Gene Polymorphisms <i>(TNF)-α</i> TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-Alpha Serum Concentration with Age-Related Macular DegenerationGuoda Zazeckyte0Greta Gedvilaite1Alvita Vilkeviciute2Loresa Kriauciuniene3Vilma Jurate Balciuniene4Ruta Mockute5Rasa Liutkeviciene6Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, LithuaniaNeuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, LithuaniaNeuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, LithuaniaNeuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, LithuaniaDepartment of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, LithuaniaMedical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, LithuaniaNeuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, LithuaniaAge-related macular degeneration (AMD) is a neurodegenerative disease leading to irreversible central vision loss among the elderly in developed countries. While the disease accounts for 9% of all cases of vision loss, the prevalence of AMD is likely to increase due to the exponential aging of the population. Due to this reason, our study aimed to determine the associations of tumor necrosis factor-alpha (<i>TNF-α</i>) gene single-nucleotide polymorphisms (SNPs) TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-α serum concentration with age-related macular degeneration. Analysis of <i>TNF-α</i> rs1800630, rs1800629, and rs361525 polymorphisms showed that the <i>TNF-α</i> rs1800630 A allele was statistically significantly more frequent in the exudative AMD group compared to the control group (<i>p</i> = 0.029). Additionally, the <i>TNF-α</i> rs1800630 A allele was more frequent in females with exudative AMD than in the control group of healthy females (<i>p</i> = 0.027). The <i>TNF-α</i> rs1800630 A allele was more frequent in females with exudative AMD than in females with early AMD (<i>p</i> = 0.014). <i>TNF-α</i> rs1800630, rs1800629, and rs361525 haplotype A-A-G were associated with decreased odds of exudative AMD (<i>p</i> < 0.0001), and haplotype A-G-G was associated with 24-fold increased exudative AMD occurrence (<i>p</i> < 0.0001). TNF-α protein levels were lower in subjects with exudative AMD compared to the control group (<i>p</i> < 0.001). The study showed significant associations between inflammatory cytokine <i>TNF-α</i> single-nucleotide polymorphisms and serum level with AMD pathogenesis. Analysis of <i>TNF-α</i> genotypes and serum concentration may be helpful for the AMD diagnosis.https://www.mdpi.com/2075-1729/12/7/928age-related macular degeneration (AMD)-1<i>TNF</i>-<i>α</i>-2rs18006303-3rs1800629-4rs361525-5 |
| spellingShingle | Guoda Zazeckyte Greta Gedvilaite Alvita Vilkeviciute Loresa Kriauciuniene Vilma Jurate Balciuniene Ruta Mockute Rasa Liutkeviciene Associations of Tumor Necrosis Factor-Alpha Gene Polymorphisms <i>(TNF)-α</i> TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-Alpha Serum Concentration with Age-Related Macular Degeneration Life age-related macular degeneration (AMD)-1 <i>TNF</i>-<i>α</i>-2 rs18006303-3 rs1800629-4 rs361525-5 |
| title | Associations of Tumor Necrosis Factor-Alpha Gene Polymorphisms <i>(TNF)-α</i> TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-Alpha Serum Concentration with Age-Related Macular Degeneration |
| title_full | Associations of Tumor Necrosis Factor-Alpha Gene Polymorphisms <i>(TNF)-α</i> TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-Alpha Serum Concentration with Age-Related Macular Degeneration |
| title_fullStr | Associations of Tumor Necrosis Factor-Alpha Gene Polymorphisms <i>(TNF)-α</i> TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-Alpha Serum Concentration with Age-Related Macular Degeneration |
| title_full_unstemmed | Associations of Tumor Necrosis Factor-Alpha Gene Polymorphisms <i>(TNF)-α</i> TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-Alpha Serum Concentration with Age-Related Macular Degeneration |
| title_short | Associations of Tumor Necrosis Factor-Alpha Gene Polymorphisms <i>(TNF)-α</i> TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-Alpha Serum Concentration with Age-Related Macular Degeneration |
| title_sort | associations of tumor necrosis factor alpha gene polymorphisms i tnf α i tnf 863a c rs1800630 tnf 308a g rs1800629 tnf 238a g rs361525 and tnf alpha serum concentration with age related macular degeneration |
| topic | age-related macular degeneration (AMD)-1 <i>TNF</i>-<i>α</i>-2 rs18006303-3 rs1800629-4 rs361525-5 |
| url | https://www.mdpi.com/2075-1729/12/7/928 |
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