Antimicrobial and cytotoxic activities of Barleria prionitis and Barleria grandiflora: A comparative study
Leaf juices as well as leaves of Barleria prionitis and Barleria grandiflora are being used by rural people across various regions of India in the treatment of oral ailments such as dental troubles, gum ailments, pyorrhoea, dental carries and mouth ulcers. Zone of inhibition and MIC values obtained...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2016-10-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/27476 |
| _version_ | 1818516284731555840 |
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| author | Hemant Arunrao Sawarkar Pranita P. Kashyap Ajit Kumar Pandey Mukesh Kumar Singh Chanchal Deep Kaur |
| author_facet | Hemant Arunrao Sawarkar Pranita P. Kashyap Ajit Kumar Pandey Mukesh Kumar Singh Chanchal Deep Kaur |
| author_sort | Hemant Arunrao Sawarkar |
| collection | DOAJ |
| description | Leaf juices as well as leaves of Barleria prionitis and Barleria grandiflora are being used by rural people across various regions of India in the treatment of oral ailments such as dental troubles, gum ailments, pyorrhoea, dental carries and mouth ulcers. Zone of inhibition and MIC values obtained for all the extracts suggest ethanolic extract of the herbs were more antimicrobial when compared to the aqueous extract. Results of biofilm suppression were found statistically significant (p<0.05) when compared to control. Cytotoxicity was evaluated by MTT assay on human gingival fibroblast and human dermal fibroblast cell lines for ethanolic extract of the herbs. CTC50 value was found to be more than 1,000 µg/mL for ethanolic extracts of both herbs. Chlorhexidine was found to be more cytotoxic with CTC50 value of 12.525 µg/mL. Ethanolic extract of B. prionitis and B. grandiflora found significantly cytotoxic (p<0.05) in comparison with control.
Video Clip of Methodology:
Cytotoxicity assay: 18 min 45 sec Full Screen Alternative |
| first_indexed | 2024-12-11T00:40:02Z |
| format | Article |
| id | doaj.art-12bb9dc034724151b98ec4a20cfaec06 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-11T00:40:02Z |
| publishDate | 2016-10-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-12bb9dc034724151b98ec4a20cfaec062022-12-22T01:26:57ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882016-10-0111410.3329/bjp.v11i4.27476Antimicrobial and cytotoxic activities of Barleria prionitis and Barleria grandiflora: A comparative studyHemant Arunrao Sawarkar0Pranita P. Kashyap1Ajit Kumar Pandey2Mukesh Kumar Singh3Chanchal Deep Kaur4Shri Rawatpura Sarkar Institute of Pharmacy, DURG, ChattisgarhShri Rawatpura Sarkar Institute of Pharmacy, DURG, ChattisgarhShri Rawatpura Sarkar Institute of Pharmacy, DURG, ChattisgarhShri Rawatpura Sarkar Institute of Pharmacy, DURG, ChattisgarhShri Rawatpura Sarkar Institute of Pharmacy, DURG, ChattisgarhLeaf juices as well as leaves of Barleria prionitis and Barleria grandiflora are being used by rural people across various regions of India in the treatment of oral ailments such as dental troubles, gum ailments, pyorrhoea, dental carries and mouth ulcers. Zone of inhibition and MIC values obtained for all the extracts suggest ethanolic extract of the herbs were more antimicrobial when compared to the aqueous extract. Results of biofilm suppression were found statistically significant (p<0.05) when compared to control. Cytotoxicity was evaluated by MTT assay on human gingival fibroblast and human dermal fibroblast cell lines for ethanolic extract of the herbs. CTC50 value was found to be more than 1,000 µg/mL for ethanolic extracts of both herbs. Chlorhexidine was found to be more cytotoxic with CTC50 value of 12.525 µg/mL. Ethanolic extract of B. prionitis and B. grandiflora found significantly cytotoxic (p<0.05) in comparison with control. Video Clip of Methodology: Cytotoxicity assay: 18 min 45 sec Full Screen Alternativehttps://www.banglajol.info/index.php/BJP/article/view/27476Barleria prionitisBarleria grandifloraAntimicrobialMinimum Inhibitory concentrationBiofilm supressionCytotoxicity. |
| spellingShingle | Hemant Arunrao Sawarkar Pranita P. Kashyap Ajit Kumar Pandey Mukesh Kumar Singh Chanchal Deep Kaur Antimicrobial and cytotoxic activities of Barleria prionitis and Barleria grandiflora: A comparative study Bangladesh Journal of Pharmacology Barleria prionitis Barleria grandiflora Antimicrobial Minimum Inhibitory concentration Biofilm supression Cytotoxicity. |
| title | Antimicrobial and cytotoxic activities of Barleria prionitis and Barleria grandiflora: A comparative study |
| title_full | Antimicrobial and cytotoxic activities of Barleria prionitis and Barleria grandiflora: A comparative study |
| title_fullStr | Antimicrobial and cytotoxic activities of Barleria prionitis and Barleria grandiflora: A comparative study |
| title_full_unstemmed | Antimicrobial and cytotoxic activities of Barleria prionitis and Barleria grandiflora: A comparative study |
| title_short | Antimicrobial and cytotoxic activities of Barleria prionitis and Barleria grandiflora: A comparative study |
| title_sort | antimicrobial and cytotoxic activities of barleria prionitis and barleria grandiflora a comparative study |
| topic | Barleria prionitis Barleria grandiflora Antimicrobial Minimum Inhibitory concentration Biofilm supression Cytotoxicity. |
| url | https://www.banglajol.info/index.php/BJP/article/view/27476 |
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