Complete Blood Count and Myocardial Markers Combination with Sequential Organ Failure Assessment Score Can Effectively Predict the Mortality in Sepsis: A Derivation and Validation Study
Keli Wen, Hu Du, Binfei Tang, Bin Xiong, An Zhang,* Pengfei Wang* Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China*These authors contributed equally to this workCorrespondence:...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-03-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/complete-blood-count-and-myocardial-markers-combination-with-sequentia-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1818775167706333184 |
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| author | Wen K Du H Tang B Xiong B Zhang A Wang P |
| author_facet | Wen K Du H Tang B Xiong B Zhang A Wang P |
| author_sort | Wen K |
| collection | DOAJ |
| description | Keli Wen, Hu Du, Binfei Tang, Bin Xiong, An Zhang,* Pengfei Wang* Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China*These authors contributed equally to this workCorrespondence: An Zhang; Pengfei Wang, Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjiang Road, Yuzhong District, Chongqing, 400010, People’s Republic of China, Tel +86 23-63693452, Email zhangan@Hospital.cqmu.edu.cn; 13436027816@163.comPurpose: The purpose of our study was to explore the prognostic value of complete blood count and myocardial markers combination with Sequential Organ Failure Assessment (SOFA) score in predicting the 28-day mortality among sepsis patients.Patients and methods: A retrospective observational cohort study was performed. Three hundred and nineteen sepsis patients who were hospitalized at the Second Affiliated Hospital of Chongqing Medical University, China, from January 2019 to September 2021 were included. The clinical and laboratory data, the Acute Physiological and Chronic Health Evaluation II (APACHE II) score and SOFA score at the time of the initial sepsis diagnosis were collected, and the predictive values of the single and combination variables for 28-day mortality were compared.Results: The derivation cohort consisted of 221 patients and included 59 (26.7%) died. The area under the curve (AUC) [95% confidence interval (CI)] of RDW and cTnT were 0.735 (0.663– 0.807) and 0.753 (0.678– 0.827) for mortality, and the cut-off value were 14.05% and 0.039 ng/mL, respectively. The combination of RDW, cTnT and the SOFA score showed a better performance for the prediction of mortality, and the AUC was significantly higher than that of the SOFA score (0.791 vs 0.726, DeLong test: P=0.032). Multivariate Cox analysis identified that the combination of RDW, cTnT and the SOFA score (HR=6.133, P=0.004) and APACHE II score (HR=1.093, P< 0.001) were independent detrimental factors for 28-day mortality. The validation cohort consisted of 98 patients and included 23 (23.5%) died. Similarly, the AUC of the RDW, cTnT and the SOFA score combination is significantly higher than that of the SOFA score (0.821 vs 0.739, DeLong test: P=0.035).Conclusion: RDW and cTnT showed good performance in predicting 28-day mortality rates among patients with sepsis. Combined RDW and cTnT with the SOFA score can significantly improve the predictive value of SOFA score for the prognosis of sepsis.Keywords: sepsis, septic shock, Sequential Organ Failure Assessment score, red blood cell distribution width, cardiac troponin T, marker |
| first_indexed | 2024-12-18T10:52:44Z |
| format | Article |
| id | doaj.art-12bc18e73e864615af7a6277c223b8ff |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-18T10:52:44Z |
| publishDate | 2022-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-12bc18e73e864615af7a6277c223b8ff2022-12-21T21:10:24ZengDove Medical PressInternational Journal of General Medicine1178-70742022-03-01Volume 153265328073876Complete Blood Count and Myocardial Markers Combination with Sequential Organ Failure Assessment Score Can Effectively Predict the Mortality in Sepsis: A Derivation and Validation StudyWen KDu HTang BXiong BZhang AWang PKeli Wen, Hu Du, Binfei Tang, Bin Xiong, An Zhang,* Pengfei Wang* Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China*These authors contributed equally to this workCorrespondence: An Zhang; Pengfei Wang, Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjiang Road, Yuzhong District, Chongqing, 400010, People’s Republic of China, Tel +86 23-63693452, Email zhangan@Hospital.cqmu.edu.cn; 13436027816@163.comPurpose: The purpose of our study was to explore the prognostic value of complete blood count and myocardial markers combination with Sequential Organ Failure Assessment (SOFA) score in predicting the 28-day mortality among sepsis patients.Patients and methods: A retrospective observational cohort study was performed. Three hundred and nineteen sepsis patients who were hospitalized at the Second Affiliated Hospital of Chongqing Medical University, China, from January 2019 to September 2021 were included. The clinical and laboratory data, the Acute Physiological and Chronic Health Evaluation II (APACHE II) score and SOFA score at the time of the initial sepsis diagnosis were collected, and the predictive values of the single and combination variables for 28-day mortality were compared.Results: The derivation cohort consisted of 221 patients and included 59 (26.7%) died. The area under the curve (AUC) [95% confidence interval (CI)] of RDW and cTnT were 0.735 (0.663– 0.807) and 0.753 (0.678– 0.827) for mortality, and the cut-off value were 14.05% and 0.039 ng/mL, respectively. The combination of RDW, cTnT and the SOFA score showed a better performance for the prediction of mortality, and the AUC was significantly higher than that of the SOFA score (0.791 vs 0.726, DeLong test: P=0.032). Multivariate Cox analysis identified that the combination of RDW, cTnT and the SOFA score (HR=6.133, P=0.004) and APACHE II score (HR=1.093, P< 0.001) were independent detrimental factors for 28-day mortality. The validation cohort consisted of 98 patients and included 23 (23.5%) died. Similarly, the AUC of the RDW, cTnT and the SOFA score combination is significantly higher than that of the SOFA score (0.821 vs 0.739, DeLong test: P=0.035).Conclusion: RDW and cTnT showed good performance in predicting 28-day mortality rates among patients with sepsis. Combined RDW and cTnT with the SOFA score can significantly improve the predictive value of SOFA score for the prognosis of sepsis.Keywords: sepsis, septic shock, Sequential Organ Failure Assessment score, red blood cell distribution width, cardiac troponin T, markerhttps://www.dovepress.com/complete-blood-count-and-myocardial-markers-combination-with-sequentia-peer-reviewed-fulltext-article-IJGMsepsisseptic shocksequential organ failure assessment scorered blood cell distribution widthcardiac troponin tmarker |
| spellingShingle | Wen K Du H Tang B Xiong B Zhang A Wang P Complete Blood Count and Myocardial Markers Combination with Sequential Organ Failure Assessment Score Can Effectively Predict the Mortality in Sepsis: A Derivation and Validation Study International Journal of General Medicine sepsis septic shock sequential organ failure assessment score red blood cell distribution width cardiac troponin t marker |
| title | Complete Blood Count and Myocardial Markers Combination with Sequential Organ Failure Assessment Score Can Effectively Predict the Mortality in Sepsis: A Derivation and Validation Study |
| title_full | Complete Blood Count and Myocardial Markers Combination with Sequential Organ Failure Assessment Score Can Effectively Predict the Mortality in Sepsis: A Derivation and Validation Study |
| title_fullStr | Complete Blood Count and Myocardial Markers Combination with Sequential Organ Failure Assessment Score Can Effectively Predict the Mortality in Sepsis: A Derivation and Validation Study |
| title_full_unstemmed | Complete Blood Count and Myocardial Markers Combination with Sequential Organ Failure Assessment Score Can Effectively Predict the Mortality in Sepsis: A Derivation and Validation Study |
| title_short | Complete Blood Count and Myocardial Markers Combination with Sequential Organ Failure Assessment Score Can Effectively Predict the Mortality in Sepsis: A Derivation and Validation Study |
| title_sort | complete blood count and myocardial markers combination with sequential organ failure assessment score can effectively predict the mortality in sepsis a derivation and validation study |
| topic | sepsis septic shock sequential organ failure assessment score red blood cell distribution width cardiac troponin t marker |
| url | https://www.dovepress.com/complete-blood-count-and-myocardial-markers-combination-with-sequentia-peer-reviewed-fulltext-article-IJGM |
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