New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome
The alveolar epithelium serves as a barrier between the body and the external environment. To maintain efficient gas exchange, the alveolar epithelium has evolved to withstand and rapidly respond to an assortment of inhaled, injury-inducing stimuli. However, alveolar damage can lead to loss of alveo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/9/1273 |
| _version_ | 1827662950983270400 |
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| author | Marilia Sanches Santos Rizzo Zuttion Sarah Kathryn Littlehale Moore Peter Chen Andrew Kota Beppu Jaime Lynn Hook |
| author_facet | Marilia Sanches Santos Rizzo Zuttion Sarah Kathryn Littlehale Moore Peter Chen Andrew Kota Beppu Jaime Lynn Hook |
| author_sort | Marilia Sanches Santos Rizzo Zuttion |
| collection | DOAJ |
| description | The alveolar epithelium serves as a barrier between the body and the external environment. To maintain efficient gas exchange, the alveolar epithelium has evolved to withstand and rapidly respond to an assortment of inhaled, injury-inducing stimuli. However, alveolar damage can lead to loss of alveolar fluid barrier function and exuberant, non-resolving inflammation that manifests clinically as acute respiratory distress syndrome (ARDS). This review discusses recent discoveries related to mechanisms of alveolar homeostasis, injury, repair, and regeneration, with a contemporary emphasis on virus-induced lung injury. In addition, we address new insights into how the alveolar epithelium coordinates injury-induced lung inflammation and review maladaptive lung responses to alveolar damage that drive ARDS and pathologic lung remodeling. |
| first_indexed | 2024-03-10T00:36:02Z |
| format | Article |
| id | doaj.art-12bc290bb4bd4508a0b4f1dc56e106a7 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T00:36:02Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-12bc290bb4bd4508a0b4f1dc56e106a72023-11-23T15:15:57ZengMDPI AGBiomolecules2218-273X2022-09-01129127310.3390/biom12091273New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress SyndromeMarilia Sanches Santos Rizzo Zuttion0Sarah Kathryn Littlehale Moore1Peter Chen2Andrew Kota Beppu3Jaime Lynn Hook4Women’s Guild Lung Institute, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USALung Imaging Laboratory, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAWomen’s Guild Lung Institute, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAWomen’s Guild Lung Institute, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USALung Imaging Laboratory, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAThe alveolar epithelium serves as a barrier between the body and the external environment. To maintain efficient gas exchange, the alveolar epithelium has evolved to withstand and rapidly respond to an assortment of inhaled, injury-inducing stimuli. However, alveolar damage can lead to loss of alveolar fluid barrier function and exuberant, non-resolving inflammation that manifests clinically as acute respiratory distress syndrome (ARDS). This review discusses recent discoveries related to mechanisms of alveolar homeostasis, injury, repair, and regeneration, with a contemporary emphasis on virus-induced lung injury. In addition, we address new insights into how the alveolar epithelium coordinates injury-induced lung inflammation and review maladaptive lung responses to alveolar damage that drive ARDS and pathologic lung remodeling.https://www.mdpi.com/2218-273X/12/9/1273ARDSalveolar epitheliumlung repairlung regenerationlung remodeling |
| spellingShingle | Marilia Sanches Santos Rizzo Zuttion Sarah Kathryn Littlehale Moore Peter Chen Andrew Kota Beppu Jaime Lynn Hook New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome Biomolecules ARDS alveolar epithelium lung repair lung regeneration lung remodeling |
| title | New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome |
| title_full | New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome |
| title_fullStr | New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome |
| title_full_unstemmed | New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome |
| title_short | New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome |
| title_sort | new insights into the alveolar epithelium as a driver of acute respiratory distress syndrome |
| topic | ARDS alveolar epithelium lung repair lung regeneration lung remodeling |
| url | https://www.mdpi.com/2218-273X/12/9/1273 |
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