A novel CNN architecture for accurate early detection and classification of Alzheimer’s disease using MRI data
Abstract Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that requires accurate diagnosis for effective management and treatment. In this article, we propose an architecture for a convolutional neural network (CNN) that utilizes magnetic resonance imaging (MRI) data from the Al...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-53733-6 |
| _version_ | 1797275190628974592 |
|---|---|
| author | A. M. El-Assy Hanan M. Amer H. M. Ibrahim M. A. Mohamed |
| author_facet | A. M. El-Assy Hanan M. Amer H. M. Ibrahim M. A. Mohamed |
| author_sort | A. M. El-Assy |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that requires accurate diagnosis for effective management and treatment. In this article, we propose an architecture for a convolutional neural network (CNN) that utilizes magnetic resonance imaging (MRI) data from the Alzheimer’s disease Neuroimaging Initiative (ADNI) dataset to categorize AD. The network employs two separate CNN models, each with distinct filter sizes and pooling layers, which are concatenated in a classification layer. The multi-class problem is addressed across three, four, and five categories. The proposed CNN architecture achieves exceptional accuracies of 99.43%, 99.57%, and 99.13%, respectively. These high accuracies demonstrate the efficacy of the network in capturing and discerning relevant features from MRI images, enabling precise classification of AD subtypes and stages. The network architecture leverages the hierarchical nature of convolutional layers, pooling layers, and fully connected layers to extract both local and global patterns from the data, facilitating accurate discrimination between different AD categories. Accurate classification of AD carries significant clinical implications, including early detection, personalized treatment planning, disease monitoring, and prognostic assessment. The reported accuracy underscores the potential of the proposed CNN architecture to assist medical professionals and researchers in making precise and informed judgments regarding AD patients. |
| first_indexed | 2024-03-07T15:10:45Z |
| format | Article |
| id | doaj.art-12bdef17b9764e629878274ceb3b6a20 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:10:45Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-12bdef17b9764e629878274ceb3b6a202024-03-05T18:39:19ZengNature PortfolioScientific Reports2045-23222024-02-0114111910.1038/s41598-024-53733-6A novel CNN architecture for accurate early detection and classification of Alzheimer’s disease using MRI dataA. M. El-Assy0Hanan M. Amer1H. M. Ibrahim2M. A. Mohamed3Electronics and Communications Engineering Department, Faculty of Engineering, Mansoura UniversityElectronics and Communications Engineering Department, Faculty of Engineering, Mansoura UniversityCommunication and Electronics Engineering Department, Nile Higher Institute for Engineering and Technology-IEEE Com Society MemberElectronics and Communications Engineering Department, Faculty of Engineering, Mansoura UniversityAbstract Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that requires accurate diagnosis for effective management and treatment. In this article, we propose an architecture for a convolutional neural network (CNN) that utilizes magnetic resonance imaging (MRI) data from the Alzheimer’s disease Neuroimaging Initiative (ADNI) dataset to categorize AD. The network employs two separate CNN models, each with distinct filter sizes and pooling layers, which are concatenated in a classification layer. The multi-class problem is addressed across three, four, and five categories. The proposed CNN architecture achieves exceptional accuracies of 99.43%, 99.57%, and 99.13%, respectively. These high accuracies demonstrate the efficacy of the network in capturing and discerning relevant features from MRI images, enabling precise classification of AD subtypes and stages. The network architecture leverages the hierarchical nature of convolutional layers, pooling layers, and fully connected layers to extract both local and global patterns from the data, facilitating accurate discrimination between different AD categories. Accurate classification of AD carries significant clinical implications, including early detection, personalized treatment planning, disease monitoring, and prognostic assessment. The reported accuracy underscores the potential of the proposed CNN architecture to assist medical professionals and researchers in making precise and informed judgments regarding AD patients.https://doi.org/10.1038/s41598-024-53733-6Alzheimer’s diseaseConvolutional neural networkDeep learningIntelligent systemsExplain ability |
| spellingShingle | A. M. El-Assy Hanan M. Amer H. M. Ibrahim M. A. Mohamed A novel CNN architecture for accurate early detection and classification of Alzheimer’s disease using MRI data Scientific Reports Alzheimer’s disease Convolutional neural network Deep learning Intelligent systems Explain ability |
| title | A novel CNN architecture for accurate early detection and classification of Alzheimer’s disease using MRI data |
| title_full | A novel CNN architecture for accurate early detection and classification of Alzheimer’s disease using MRI data |
| title_fullStr | A novel CNN architecture for accurate early detection and classification of Alzheimer’s disease using MRI data |
| title_full_unstemmed | A novel CNN architecture for accurate early detection and classification of Alzheimer’s disease using MRI data |
| title_short | A novel CNN architecture for accurate early detection and classification of Alzheimer’s disease using MRI data |
| title_sort | novel cnn architecture for accurate early detection and classification of alzheimer s disease using mri data |
| topic | Alzheimer’s disease Convolutional neural network Deep learning Intelligent systems Explain ability |
| url | https://doi.org/10.1038/s41598-024-53733-6 |
| work_keys_str_mv | AT amelassy anovelcnnarchitectureforaccurateearlydetectionandclassificationofalzheimersdiseaseusingmridata AT hananmamer anovelcnnarchitectureforaccurateearlydetectionandclassificationofalzheimersdiseaseusingmridata AT hmibrahim anovelcnnarchitectureforaccurateearlydetectionandclassificationofalzheimersdiseaseusingmridata AT mamohamed anovelcnnarchitectureforaccurateearlydetectionandclassificationofalzheimersdiseaseusingmridata AT amelassy novelcnnarchitectureforaccurateearlydetectionandclassificationofalzheimersdiseaseusingmridata AT hananmamer novelcnnarchitectureforaccurateearlydetectionandclassificationofalzheimersdiseaseusingmridata AT hmibrahim novelcnnarchitectureforaccurateearlydetectionandclassificationofalzheimersdiseaseusingmridata AT mamohamed novelcnnarchitectureforaccurateearlydetectionandclassificationofalzheimersdiseaseusingmridata |