Red cell distribution width is associated with short‐term mortality in critically ill patients with heart failure
Abstract Aims There is limited evidence for the correlation between short‐term mortality and red cell distribution width (RDW) in critical patients with heart failure. Herein, a retrospective cohort study was conducted to investigate whether RDW was independently associated with short‐term mortality...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.14023 |
| _version_ | 1797794267698036736 |
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| author | Xinyu Zhang Yi Wang Naiyi Chen Yan Liu Jie Xiao Zongwei Lin Huixia Lu Xiaoping Ji |
| author_facet | Xinyu Zhang Yi Wang Naiyi Chen Yan Liu Jie Xiao Zongwei Lin Huixia Lu Xiaoping Ji |
| author_sort | Xinyu Zhang |
| collection | DOAJ |
| description | Abstract Aims There is limited evidence for the correlation between short‐term mortality and red cell distribution width (RDW) in critical patients with heart failure. Herein, a retrospective cohort study was conducted to investigate whether RDW was independently associated with short‐term mortality in critically ill patients with heart failure. Methods and results As a retrospective cohort study, it involved a total of 9465 patients with heart failure from the MIMIC‐IV database. The target‐dependent and independent variables were in‐hospital mortality, 90 day mortality and RDW measured at baseline, respectively. The relationship between all‐cause death and baseline RDW in hospital and after 90 days of admission to ICU was evaluated by using the Kaplan–Meier plot and Cox proportional hazard analysis. The average age of participants was 74.4 (64.2, 83.5) years old, among whom about 54.6% were male. Results of the adjusted Cox proportional hazard model revealed that RDW had a positive association with both in‐hospital and 90 day mortality risk after the adjustment of confounders (HR = 1.09, 95% CI: 1.04–1.15, P < 0.001; HR = 1.11, 95% CI: 1.08–1.14, P < 0.001, respectively). A non‐linear relationship was found between RDW and 90 day mortality, which had a threshold of 14.96%. The effect sizes and confidence intervals below and above the threshold were 1.36 (1.14 to 1.62) and 1.09 (1.04 to 1.15), respectively. It was also found by subgroup analysis that there were stronger correlations in male and patients with normal renal function. Conclusions Our data suggest that the short‐term mortality of critically ill patients with HF is independently predicted by RDW. At the same time, large prospective research and longer follow‐up time are required to further validate the findings of this study. |
| first_indexed | 2024-03-13T03:00:15Z |
| format | Article |
| id | doaj.art-12beda512cde424f9d26a19f9a18d313 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-03-13T03:00:15Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-12beda512cde424f9d26a19f9a18d3132023-06-27T14:49:57ZengWileyESC Heart Failure2055-58222022-10-01953210322010.1002/ehf2.14023Red cell distribution width is associated with short‐term mortality in critically ill patients with heart failureXinyu Zhang0Yi Wang1Naiyi Chen2Yan Liu3Jie Xiao4Zongwei Lin5Huixia Lu6Xiaoping Ji7The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan ChinaAbstract Aims There is limited evidence for the correlation between short‐term mortality and red cell distribution width (RDW) in critical patients with heart failure. Herein, a retrospective cohort study was conducted to investigate whether RDW was independently associated with short‐term mortality in critically ill patients with heart failure. Methods and results As a retrospective cohort study, it involved a total of 9465 patients with heart failure from the MIMIC‐IV database. The target‐dependent and independent variables were in‐hospital mortality, 90 day mortality and RDW measured at baseline, respectively. The relationship between all‐cause death and baseline RDW in hospital and after 90 days of admission to ICU was evaluated by using the Kaplan–Meier plot and Cox proportional hazard analysis. The average age of participants was 74.4 (64.2, 83.5) years old, among whom about 54.6% were male. Results of the adjusted Cox proportional hazard model revealed that RDW had a positive association with both in‐hospital and 90 day mortality risk after the adjustment of confounders (HR = 1.09, 95% CI: 1.04–1.15, P < 0.001; HR = 1.11, 95% CI: 1.08–1.14, P < 0.001, respectively). A non‐linear relationship was found between RDW and 90 day mortality, which had a threshold of 14.96%. The effect sizes and confidence intervals below and above the threshold were 1.36 (1.14 to 1.62) and 1.09 (1.04 to 1.15), respectively. It was also found by subgroup analysis that there were stronger correlations in male and patients with normal renal function. Conclusions Our data suggest that the short‐term mortality of critically ill patients with HF is independently predicted by RDW. At the same time, large prospective research and longer follow‐up time are required to further validate the findings of this study.https://doi.org/10.1002/ehf2.14023Red cell distribution widthCritically ill patients with heart failurePrognosis |
| spellingShingle | Xinyu Zhang Yi Wang Naiyi Chen Yan Liu Jie Xiao Zongwei Lin Huixia Lu Xiaoping Ji Red cell distribution width is associated with short‐term mortality in critically ill patients with heart failure ESC Heart Failure Red cell distribution width Critically ill patients with heart failure Prognosis |
| title | Red cell distribution width is associated with short‐term mortality in critically ill patients with heart failure |
| title_full | Red cell distribution width is associated with short‐term mortality in critically ill patients with heart failure |
| title_fullStr | Red cell distribution width is associated with short‐term mortality in critically ill patients with heart failure |
| title_full_unstemmed | Red cell distribution width is associated with short‐term mortality in critically ill patients with heart failure |
| title_short | Red cell distribution width is associated with short‐term mortality in critically ill patients with heart failure |
| title_sort | red cell distribution width is associated with short term mortality in critically ill patients with heart failure |
| topic | Red cell distribution width Critically ill patients with heart failure Prognosis |
| url | https://doi.org/10.1002/ehf2.14023 |
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