A link between phenotypic robustness and life expectancy in Drosophila melanogaster
Long-lived systems are expected to be stable, i. e. resistant to either external influences, or internal failures. Robustness of biological systems can be defined as a reciprocal value to their phenotypic plasticity expressed through a coefficient of variation (C.V.) for positively distributed pheno...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2017-12-01
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| Series: | Вавиловский журнал генетики и селекции |
| Subjects: | |
| Online Access: | https://vavilov.elpub.ru/jour/article/view/1231 |
| _version_ | 1797214056599257088 |
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| author | L. P. Zakharenko D. V. Petrovskii I. G. Dranov S. A. Fedorova N. S. Yudin A. V. Pindyurin Y. M. Moshkin |
| author_facet | L. P. Zakharenko D. V. Petrovskii I. G. Dranov S. A. Fedorova N. S. Yudin A. V. Pindyurin Y. M. Moshkin |
| author_sort | L. P. Zakharenko |
| collection | DOAJ |
| description | Long-lived systems are expected to be stable, i. e. resistant to either external influences, or internal failures. Robustness of biological systems can be defined as a reciprocal value to their phenotypic plasticity expressed through a coefficient of variation (C.V.) for positively distributed phenotypic traits. Considering lifespan as phenotype, which integrates all functions of an organism, we showed that its phenotypic robustness correlates positively with life expectancy. We assessed lifespan parameters for a selection of inbred Drosophila melanogaster strains from Drosophila Genetic Reference Panel (DGRP) reared at 29 ºС. The robustness of lifespan phenotype (C.V.–1) correlated positively with estimated life expectancy for these strains. The same relation also holds for the lifespan of all DGRP strains reared at 25 ºС. Also, in agreement with previous observations, upon temperature change (decrease or increase) the survival curves scaled in time (stretched or shrunk respectively). In other words, the average lifespan decreased for flies reared at elevated temperature, but so did the standard deviation, and thus the coefficients of variation remained in the same range. From this we conclude that coefficients of variation correlate with life expectancies and account for the robustness of lifespan phenotype irrespective of accelerated aging caused by temperature. |
| first_indexed | 2024-03-07T16:06:48Z |
| format | Article |
| id | doaj.art-12c0718049564042bdb109f2631cf71f |
| institution | Directory Open Access Journal |
| issn | 2500-3259 |
| language | English |
| last_indexed | 2024-04-24T11:08:06Z |
| publishDate | 2017-12-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj.art-12c0718049564042bdb109f2631cf71f2024-04-11T15:30:58ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592017-12-0121781682410.18699/VJ17.301689A link between phenotypic robustness and life expectancy in Drosophila melanogasterL. P. Zakharenko0D. V. Petrovskii1I. G. Dranov2S. A. Fedorova3N. S. Yudin4A. V. Pindyurin5Y. M. Moshkin6Institute of Cytology and Genetics SB RAS.Institute of Cytology and Genetics SB RAS.Voevodsky Institute of Chemical Kinetics and Combustion SB RAS.Institute of Cytology and Genetics SB RAS.Institute of Cytology and Genetics SB RAS.Institute of Molecular and Cellular Biology SB RAS.Institute of Cytology and Genetics SB RAS; Institute of Molecular and Cellular Biology SB RAS.Long-lived systems are expected to be stable, i. e. resistant to either external influences, or internal failures. Robustness of biological systems can be defined as a reciprocal value to their phenotypic plasticity expressed through a coefficient of variation (C.V.) for positively distributed phenotypic traits. Considering lifespan as phenotype, which integrates all functions of an organism, we showed that its phenotypic robustness correlates positively with life expectancy. We assessed lifespan parameters for a selection of inbred Drosophila melanogaster strains from Drosophila Genetic Reference Panel (DGRP) reared at 29 ºС. The robustness of lifespan phenotype (C.V.–1) correlated positively with estimated life expectancy for these strains. The same relation also holds for the lifespan of all DGRP strains reared at 25 ºС. Also, in agreement with previous observations, upon temperature change (decrease or increase) the survival curves scaled in time (stretched or shrunk respectively). In other words, the average lifespan decreased for flies reared at elevated temperature, but so did the standard deviation, and thus the coefficients of variation remained in the same range. From this we conclude that coefficients of variation correlate with life expectancies and account for the robustness of lifespan phenotype irrespective of accelerated aging caused by temperature.https://vavilov.elpub.ru/jour/article/view/1231lifespanlife expectancyagingphenotypic plasticityphenotypic robustnessdrosophila melanogaster |
| spellingShingle | L. P. Zakharenko D. V. Petrovskii I. G. Dranov S. A. Fedorova N. S. Yudin A. V. Pindyurin Y. M. Moshkin A link between phenotypic robustness and life expectancy in Drosophila melanogaster Вавиловский журнал генетики и селекции lifespan life expectancy aging phenotypic plasticity phenotypic robustness drosophila melanogaster |
| title | A link between phenotypic robustness and life expectancy in Drosophila melanogaster |
| title_full | A link between phenotypic robustness and life expectancy in Drosophila melanogaster |
| title_fullStr | A link between phenotypic robustness and life expectancy in Drosophila melanogaster |
| title_full_unstemmed | A link between phenotypic robustness and life expectancy in Drosophila melanogaster |
| title_short | A link between phenotypic robustness and life expectancy in Drosophila melanogaster |
| title_sort | link between phenotypic robustness and life expectancy in drosophila melanogaster |
| topic | lifespan life expectancy aging phenotypic plasticity phenotypic robustness drosophila melanogaster |
| url | https://vavilov.elpub.ru/jour/article/view/1231 |
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