Evaluation of Anticancer, Antioxidant, and Possible Anti-inflammatory Properties of Selected Medicinal Plants Used in Indian Traditional Medication
The present study was carried out to evaluate the anticancer, antioxidant, and possible anti-inflammatory properties of diverse medicinal plants frequently used in Indian traditional medication. The selected botanicals such as Soymida fembrifuga (Roxb.) A. Juss. (Miliaceae), Tinospora cordifolia (Wi...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-10-01
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| Series: | Journal of Traditional and Complementary Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411016302401 |
| _version_ | 1811239506798444544 |
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| author | Rafik Shaikh Mahesh Pund Ashwini Dawane Sayyed Iliyas |
| author_facet | Rafik Shaikh Mahesh Pund Ashwini Dawane Sayyed Iliyas |
| author_sort | Rafik Shaikh |
| collection | DOAJ |
| description | The present study was carried out to evaluate the anticancer, antioxidant, and possible anti-inflammatory properties of diverse medicinal plants frequently used in Indian traditional medication. The selected botanicals such as Soymida fembrifuga (Roxb.) A. Juss. (Miliaceae), Tinospora cordifolia (Willd.) Miers. (Menispermaceae), Lavandula bipinnata (L.) O. Ktze. (Lamiaceae), and Helicteres isora L. (Sterculiaceae) extracted in different solvents were evaluated for their in vitro anticancer and antioxidant activities. The results obtained indicate that H. isora has potent cytotoxic activity toward the selected cancer cells such as HeLa-B75 (34.21±0.24%), HL-60 (30.25±1.36%), HEP-3B (25.36±1.78%), and PN-15 (29.21±0.52%). Interestingly, the selected botanicals selectively inhibited cyclooxygenase-2 (COX-2) more than (COX-1), which are the key enzymes implicated in inflammation. COX-2 inhibition was observed to be in the range of 19.66-49.52% as compared to COX-1 inhibition (3.93-19.61%). The results of the antioxidant study revealed that the selected plants were found to be effective 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl (OH), and superoxide radical (SOR) scavenging agents. High-performance thin layer chromatography (HPTLC) fingerprint of flavonoids was used as a measure of quality control of the selected plant samples. The results of the present findings strengthen the potential of the selected plants as a resource for the discovery of novel anticancer, anti-inflammatory, and antioxidant agents. |
| first_indexed | 2024-04-12T13:00:59Z |
| format | Article |
| id | doaj.art-12c0958a58ca47639f594bed3ef204ce |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-04-12T13:00:59Z |
| publishDate | 2014-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-12c0958a58ca47639f594bed3ef204ce2022-12-22T03:32:09ZengElsevierJournal of Traditional and Complementary Medicine2225-41102014-10-014425325710.4103/2225-4110.128904Evaluation of Anticancer, Antioxidant, and Possible Anti-inflammatory Properties of Selected Medicinal Plants Used in Indian Traditional MedicationRafik Shaikh0Mahesh Pund1Ashwini Dawane2Sayyed Iliyas3School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded - 431 606, Maharashtra, India.School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded - 431 606, Maharashtra, India.School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded - 431 606, Maharashtra, India.Department of Botany, Poona College, Camp, Pune - 411 001, Maharashtra, India.The present study was carried out to evaluate the anticancer, antioxidant, and possible anti-inflammatory properties of diverse medicinal plants frequently used in Indian traditional medication. The selected botanicals such as Soymida fembrifuga (Roxb.) A. Juss. (Miliaceae), Tinospora cordifolia (Willd.) Miers. (Menispermaceae), Lavandula bipinnata (L.) O. Ktze. (Lamiaceae), and Helicteres isora L. (Sterculiaceae) extracted in different solvents were evaluated for their in vitro anticancer and antioxidant activities. The results obtained indicate that H. isora has potent cytotoxic activity toward the selected cancer cells such as HeLa-B75 (34.21±0.24%), HL-60 (30.25±1.36%), HEP-3B (25.36±1.78%), and PN-15 (29.21±0.52%). Interestingly, the selected botanicals selectively inhibited cyclooxygenase-2 (COX-2) more than (COX-1), which are the key enzymes implicated in inflammation. COX-2 inhibition was observed to be in the range of 19.66-49.52% as compared to COX-1 inhibition (3.93-19.61%). The results of the antioxidant study revealed that the selected plants were found to be effective 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl (OH), and superoxide radical (SOR) scavenging agents. High-performance thin layer chromatography (HPTLC) fingerprint of flavonoids was used as a measure of quality control of the selected plant samples. The results of the present findings strengthen the potential of the selected plants as a resource for the discovery of novel anticancer, anti-inflammatory, and antioxidant agents.http://www.sciencedirect.com/science/article/pii/S2225411016302401AnticancerAnti-inflammatoryAntioxidantMedicinal plants |
| spellingShingle | Rafik Shaikh Mahesh Pund Ashwini Dawane Sayyed Iliyas Evaluation of Anticancer, Antioxidant, and Possible Anti-inflammatory Properties of Selected Medicinal Plants Used in Indian Traditional Medication Journal of Traditional and Complementary Medicine Anticancer Anti-inflammatory Antioxidant Medicinal plants |
| title | Evaluation of Anticancer, Antioxidant, and Possible Anti-inflammatory Properties of Selected Medicinal Plants Used in Indian Traditional Medication |
| title_full | Evaluation of Anticancer, Antioxidant, and Possible Anti-inflammatory Properties of Selected Medicinal Plants Used in Indian Traditional Medication |
| title_fullStr | Evaluation of Anticancer, Antioxidant, and Possible Anti-inflammatory Properties of Selected Medicinal Plants Used in Indian Traditional Medication |
| title_full_unstemmed | Evaluation of Anticancer, Antioxidant, and Possible Anti-inflammatory Properties of Selected Medicinal Plants Used in Indian Traditional Medication |
| title_short | Evaluation of Anticancer, Antioxidant, and Possible Anti-inflammatory Properties of Selected Medicinal Plants Used in Indian Traditional Medication |
| title_sort | evaluation of anticancer antioxidant and possible anti inflammatory properties of selected medicinal plants used in indian traditional medication |
| topic | Anticancer Anti-inflammatory Antioxidant Medicinal plants |
| url | http://www.sciencedirect.com/science/article/pii/S2225411016302401 |
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