Meta-analyses of the association between the PPARGC1A Gly482Ser polymorphism and athletic performance
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) encoded by the PPARGC1A gene is a vital regulator of glucose and fatty acid oxidation, mitochondrial biogenesis, and skeletal muscle fibre conversion. Several studies have investigated the association between PPARGC1A Gly482Ser poly...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2019-10-01
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| Series: | Biology of Sport |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Meta-analyses-of-the-association-between-the-PPARGC1A-Gly482Ser-polymorphism-and-athletic-performance,78,38036,1,1.html |
| _version_ | 1818537113024462848 |
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| author | Ying Chen Dongmei Wang Pingping Yan Shenglan Yan Qing Chang Zhi Cheng |
| author_facet | Ying Chen Dongmei Wang Pingping Yan Shenglan Yan Qing Chang Zhi Cheng |
| author_sort | Ying Chen |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) encoded by the PPARGC1A gene is a vital regulator of glucose and fatty acid oxidation, mitochondrial biogenesis, and skeletal muscle fibre conversion. Several studies have investigated the association between PPARGC1A Gly482Ser polymorphism and athletic performance in humans. However, the results were contradictory. In the present study, two metaanalyses were performed to assess the association between the Gly482Ser polymorphism and endurance or power athletic performance to resolve this inconsistency. Ten articles were identified, including a total of 3,708 athletes and 6,228 controls. Higher frequencies of the Gly/Gly genotype (OR, 1.26; 95% CI, 1.11–1.42) and the Gly allele (OR, 1.29; 95% CI, 1.09–1.52) were observed in Caucasian endurance athletes. Furthermore, higher incidences of the Gly/Gly genotype (OR, 1.30; 95% CI, 1.16–1.46) and the Gly allele (OR, 1.22; 95% CI, 1.12–1.33) were observed in power athletes compared to controls. This finding demonstrates that the Gly/Gly genotype and the Gly allele of the PPARGC1A Gly482Ser polymorphism may facilitate athletic performance regardless of the type of sport, as well as providing solid evidence to support the possible influence of genetic factors on human athletic performance. |
| first_indexed | 2024-12-11T18:46:34Z |
| format | Article |
| id | doaj.art-12c1a5f3671840138140d0f2a3c45cff |
| institution | Directory Open Access Journal |
| issn | 0860-021X 2083-1862 |
| language | English |
| last_indexed | 2024-12-11T18:46:34Z |
| publishDate | 2019-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Biology of Sport |
| spelling | doaj.art-12c1a5f3671840138140d0f2a3c45cff2022-12-22T00:54:26ZengTermedia Publishing HouseBiology of Sport0860-021X2083-18622019-10-0136430130910.5114/biolsport.2019.8875238036Meta-analyses of the association between the PPARGC1A Gly482Ser polymorphism and athletic performanceYing ChenDongmei WangPingping YanShenglan YanQing ChangZhi ChengPeroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) encoded by the PPARGC1A gene is a vital regulator of glucose and fatty acid oxidation, mitochondrial biogenesis, and skeletal muscle fibre conversion. Several studies have investigated the association between PPARGC1A Gly482Ser polymorphism and athletic performance in humans. However, the results were contradictory. In the present study, two metaanalyses were performed to assess the association between the Gly482Ser polymorphism and endurance or power athletic performance to resolve this inconsistency. Ten articles were identified, including a total of 3,708 athletes and 6,228 controls. Higher frequencies of the Gly/Gly genotype (OR, 1.26; 95% CI, 1.11–1.42) and the Gly allele (OR, 1.29; 95% CI, 1.09–1.52) were observed in Caucasian endurance athletes. Furthermore, higher incidences of the Gly/Gly genotype (OR, 1.30; 95% CI, 1.16–1.46) and the Gly allele (OR, 1.22; 95% CI, 1.12–1.33) were observed in power athletes compared to controls. This finding demonstrates that the Gly/Gly genotype and the Gly allele of the PPARGC1A Gly482Ser polymorphism may facilitate athletic performance regardless of the type of sport, as well as providing solid evidence to support the possible influence of genetic factors on human athletic performance.https://www.termedia.pl/Meta-analyses-of-the-association-between-the-PPARGC1A-Gly482Ser-polymorphism-and-athletic-performance,78,38036,1,1.htmlmeta-analysis ppargc1a polymorphism endurance power athletic performance |
| spellingShingle | Ying Chen Dongmei Wang Pingping Yan Shenglan Yan Qing Chang Zhi Cheng Meta-analyses of the association between the PPARGC1A Gly482Ser polymorphism and athletic performance Biology of Sport meta-analysis ppargc1a polymorphism endurance power athletic performance |
| title | Meta-analyses of the association between the PPARGC1A Gly482Ser polymorphism and athletic performance |
| title_full | Meta-analyses of the association between the PPARGC1A Gly482Ser polymorphism and athletic performance |
| title_fullStr | Meta-analyses of the association between the PPARGC1A Gly482Ser polymorphism and athletic performance |
| title_full_unstemmed | Meta-analyses of the association between the PPARGC1A Gly482Ser polymorphism and athletic performance |
| title_short | Meta-analyses of the association between the PPARGC1A Gly482Ser polymorphism and athletic performance |
| title_sort | meta analyses of the association between the ppargc1a gly482ser polymorphism and athletic performance |
| topic | meta-analysis ppargc1a polymorphism endurance power athletic performance |
| url | https://www.termedia.pl/Meta-analyses-of-the-association-between-the-PPARGC1A-Gly482Ser-polymorphism-and-athletic-performance,78,38036,1,1.html |
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