Maternal SARS-CoV-2 infection in pregnancy disrupts gene expression in Hofbauer cells with limited impact on cytotrophoblasts.

Maternal SARS-CoV-2 infection in pregnancy disrupts gene expression in Hofbauer cells with limited impact on cytotrophoblasts.

<h4>Background</h4>Hofbauer cells (HBCs) and cytotrophoblasts (CTBs) are major cell populations in placenta. The indirect impact of maternal SARS-CoV-2 disease on these cells that are not directly infected has not been extensively studied. Herein, we profiled gene expression in HBCs and...

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Main Authors: Elizabeth Ann L Enninga, Huy Quang Quach, Jin Sung Jang, Maria Cristina Miranda de Araujo Correia, Yaroslav Fedyshyn, Bohdana Fedyshyn, Maureen Lemens, Dawn Littlefield, Supriya Behl, Elise Sintim-Aboagye, Maria C Mejia Plazas, Maria C Cardenas, Shree Chakraborty, Satoko Yamaoka, Hideki Ebihara, Akhilesh Pandey, Hu Li, Andrew D Badley, Erica L Johnson, Jie Sun, Andrew P Norgan, Regan N Theiler, Rana Chakraborty
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-02-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011990&type=printable

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